Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 148259663

GI number: 148259663

Start: 732918

End: 733865

Strand: Reverse

Name: lpxK [H]

Synonym: Acry_0650

Alternate gene names: 148259663

Gene position: 733865-732918 (Counterclockwise)

Preceding gene: 148259664

Following gene: 148259662

Centisome position: 21.65

GC content: 76.9

Gene sequence:

>948_bases
ATGCGCGCCCCCGCCTTCTGGACCACCGACGCCTTCCCGGCGCCGCTCCTCGCCCCGCTCGGCGCGATCACGCGCGCGCT
GACCGCCCGGCGCGTCGCCCGGCCGGGATTCCGCTCCGGCGCGCGCGTCTTCTGCGCCGGCAATGCCGGGGTCGGCGGCG
CCGGCAAGACCATCCTCGCGCGGCACCTGCTCGCCCGCCTCGCCGACCGGGGCGAGACGGTCTTCGCCCTCACCCGCGGG
CATGGCGGGCGCCTCGCCGGGCCGCTGCGGGTCGACCCCGCCCGGCACGGTGCCGCCGAGGTGGGCGACGAGGCGCTTCT
CCTCGCCGCGACCGCGCCGACCATCGTCGCCCGCGACCGCGCGGCCGGCGCCGCCTTCGCGGTCGCCGCCGGCGCGACCG
CCATCGTCATGGATGACGGGCTGCAGAACCCCGATCCGGTGAAAACCGCGTCGTTCCTCGTCATCGATGGCGGGGCCGGC
TTCGGCAACGGGCGGCTGCTGCCGGCAGGGCCGCTGCGCGAGCCGGTCGAAGCAGCCGCCCGGCGCTGCGCCGCGGCGGT
GCTGATCGGCGCCGACCGCACCGGCGCCCGCGCCGCGCTGCCGCCATCCCTGCCGGTGCTCACCGCCCGCCTCGTCACCG
ATGCCGGGCAGCTCGCCGGCGCCCGCGTGCTCGGCTTCGCCGGGATCGGCCGGCCGGAGAAATTCTTCGAATCACTCAGC
GATGCCGGCGCCGAGATCGCCGGCACGCTGCCCTTCCCCGACCATCACGCCTATCGCCCGGCCGATCTCGCCCGGCTCGA
CGCCGAGGCAAGCCGCCTCGGCGCCCGCCTCGCCACCACCGCGAAGGACGCGGTGAAACTGCCGCCGGCATTCCGCGCAC
GCTGCGCGGTGATCGAGGCGGGGCTTGCCTTCGACGACCCGGCCGCGCTTGATCGGTTCCTGACATGA

Upstream 100 bases:

>100_bases
CCCGCCGCGCCGCGATGGCCGCATCCGGCCGCGCCGCCTGCGCCGGGCTCGCCGGCCTGCCCGCCCGGCTGGCCCGCACC
GTTCTCGACGAGGCTCCCTG

Downstream 100 bases:

>100_bases
GCCTCCTGCACAAGATCGAAACCACCGCGGCACGCGCCTTCCTCGGCATCTTCCGCGCCCTTGGCCCGCGTGCCGCGAGC
AACCTCGCCGGCGCGCTCGG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRAPAFWTTDAFPAPLLAPLGAITRALTARRVARPGFRSGARVFCAGNAGVGGAGKTILARHLLARLADRGETVFALTRG
HGGRLAGPLRVDPARHGAAEVGDEALLLAATAPTIVARDRAAGAAFAVAAGATAIVMDDGLQNPDPVKTASFLVIDGGAG
FGNGRLLPAGPLREPVEAAARRCAAAVLIGADRTGARAALPPSLPVLTARLVTDAGQLAGARVLGFAGIGRPEKFFESLS
DAGAEIAGTLPFPDHHAYRPADLARLDAEASRLGARLATTAKDAVKLPPAFRARCAVIEAGLAFDDPAALDRFLT

Sequences:

>Translated_315_residues
MRAPAFWTTDAFPAPLLAPLGAITRALTARRVARPGFRSGARVFCAGNAGVGGAGKTILARHLLARLADRGETVFALTRG
HGGRLAGPLRVDPARHGAAEVGDEALLLAATAPTIVARDRAAGAAFAVAAGATAIVMDDGLQNPDPVKTASFLVIDGGAG
FGNGRLLPAGPLREPVEAAARRCAAAVLIGADRTGARAALPPSLPVLTARLVTDAGQLAGARVLGFAGIGRPEKFFESLS
DAGAEIAGTLPFPDHHAYRPADLARLDAEASRLGARLATTAKDAVKLPPAFRARCAVIEAGLAFDDPAALDRFLT
>Mature_315_residues
MRAPAFWTTDAFPAPLLAPLGAITRALTARRVARPGFRSGARVFCAGNAGVGGAGKTILARHLLARLADRGETVFALTRG
HGGRLAGPLRVDPARHGAAEVGDEALLLAATAPTIVARDRAAGAAFAVAAGATAIVMDDGLQNPDPVKTASFLVIDGGAG
FGNGRLLPAGPLREPVEAAARRCAAAVLIGADRTGARAALPPSLPVLTARLVTDAGQLAGARVLGFAGIGRPEKFFESLS
DAGAEIAGTLPFPDHHAYRPADLARLDAEASRLGARLATTAKDAVKLPPAFRARCAVIEAGLAFDDPAALDRFLT

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=289, Percent_Identity=33.5640138408304, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 32115; Mature: 32115

Theoretical pI: Translated: 10.81; Mature: 10.81

Prosite motif: PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPAFWTTDAFPAPLLAPLGAITRALTARRVARPGFRSGARVFCAGNAGVGGAGKTILA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHH
RHLLARLADRGETVFALTRGHGGRLAGPLRVDPARHGAAEVGDEALLLAATAPTIVARDR
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHCCCCEEEEEECCCEEEECCC
AAGAAFAVAAGATAIVMDDGLQNPDPVKTASFLVIDGGAGFGNGRLLPAGPLREPVEAAA
CCCCCEEHHCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEECCCCCCCHHHHHHH
RRCAAAVLIGADRTGARAALPPSLPVLTARLVTDAGQLAGARVLGFAGIGRPEKFFESLS
HHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHH
DAGAEIAGTLPFPDHHAYRPADLARLDAEASRLGARLATTAKDAVKLPPAFRARCAVIEA
HCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
GLAFDDPAALDRFLT
CCCCCCHHHHHHHCC
>Mature Secondary Structure
MRAPAFWTTDAFPAPLLAPLGAITRALTARRVARPGFRSGARVFCAGNAGVGGAGKTILA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHH
RHLLARLADRGETVFALTRGHGGRLAGPLRVDPARHGAAEVGDEALLLAATAPTIVARDR
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHCCCCEEEEEECCCEEEECCC
AAGAAFAVAAGATAIVMDDGLQNPDPVKTASFLVIDGGAGFGNGRLLPAGPLREPVEAAA
CCCCCEEHHCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCEECCCCCCCHHHHHHH
RRCAAAVLIGADRTGARAALPPSLPVLTARLVTDAGQLAGARVLGFAGIGRPEKFFESLS
HHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHH
DAGAEIAGTLPFPDHHAYRPADLARLDAEASRLGARLATTAKDAVKLPPAFRARCAVIEA
HCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
GLAFDDPAALDRFLT
CCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA