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The map label for this gene is zraS [C]

Identifier: 148259594

GI number: 148259594

Start: 649401

End: 651299

Strand: Reverse

Name: zraS [C]

Synonym: Acry_0578

Alternate gene names: 148259594

Gene position: 651299-649401 (Counterclockwise)

Preceding gene: 148259596

Following gene: 148259592

Centisome position: 19.22

GC content: 69.62

Gene sequence:

>1899_bases
ATGACTCCGGAGCCCGAAGCCCCCGACGCGCCGCTGGCCTTCGCCCGATCCTTCGAGGCCGCGCTGATCGGCAAGTCGCT
CGACGGCATCATCACGTCGTGGAGCGAAGGCGCCGAGAATCTGTTCGGCTATCGCGCGGACGAAATCATCGGGCGCTCGA
TCCATGTGCTGGCGCCGCCCGGGCGCGAGGCGGAAATGGACGAGCTGCTGGCCCGGACGGCAAGGGGCGAGACCTTCGAC
CAGTTCGAGACCATCCGCCGGCGCAAGGACGGCACGCTCGTCCGCGTGCTGCTCACGCTCAACCCGGTGCACGATACGGA
AGGCTGCATCGTCGGCATTTCCAAGATCGCGCGGGATATCACCGAGCATCGCAGCACCGAGGCCAGGCTCCGCTCGATCC
TCGACACCGCGCCGGATGCCATCGTCGTGATCGATCCGCGCGGCACCGTGAGGTCGTTCAGCCAGGCGGCGGAGCGGATG
TTCGGCTACGCCGCCGAGGAGGTCGTCGGCCGCAACGTGTCGATGCTGATGGCCGAGCCCCATGCCGCCGCGCATGACGG
CTATCTCGCCCGTTACCTCGAAACCGGCGAACGGCGCATCATCGGCATCGGCCGCGAGGTGGAGGCCCGCCGGGCCGATG
GCTCGACCTTCCCGATCGAACTCGCCGTCGGCGAGGTCGACCTGCCGGAGACGAGGCTGTTCACCGGCTTCATCCGCGAC
GCCAGCAAGCGCAAGCGGCTCGAGAACGACCTTGCCCAGGCGCAGAAGATGGAGGCGGTGGGCCAGCTTACCGGCGGCCT
CGCCCATGATTTCAACAACCTGCTGGCGGTGATTTCCGGCAATCTCGAAATGCTGGAGAGCCATGTCGCCGGCGGCGAGG
CGGCGGAACTGCTCGCCGAGGCCCGGCTCGCCACCGAACGCGGCGCCGAACTGGCGGCAAGGCTGCTCGCCTTCGGCCGG
CGGCAGACCCTTCGTCCGCTCGCGATCGACGTGAACGAGCTCGTCGGGAAGATGGCGCCGCTGTTCCGCCGCACGCTCGG
CTCGCCGGTCATGATCGAGACCCGGCTCGCCGCCGGGCTGCCACGCACCATGGCGGATCCCGGACAGATCGAGACGGCGC
TGCTCAACCTCGCCCTCAACGCGCGGGATGCCATGCCCAAGGGCGGCCGTCTCGTGATCGAGACCGGCCTGCTCCATGTC
GACGCCGACTATGCGGCACAACAGGCCGAGACCCTGCCGGGCGATTATGTGGTCCTGGCGGTGACGGATAGCGGGATCGG
CATGAGCGCCGAAACGCGGGGCCGCGCCTTCGAGCCGTTCTTCACCACCAAGGCGGTCGGCGAGGGATCGGGGCTGGGCC
TGTCCATGGTCTACGGCTTCGTCAAGCAGAGCGGCGGCCATGTGCAGATCTATTCCGAACCGGGCCTCGGCACCACGGTT
CGCCTGTTCCTGCCGGCGATCCGGGCCGAAATGCCCGCCGCCGACGACGAGGCGGCCCCCTCCCCGCCGCCGGGCCGGGC
GATCGTTCTCGTGGTCGAGGACGATCCCGCGGTGCGGCGCGTTGCGGAGCGCCGGCTTGCCCGCCTCGGCTATTCCACGA
TCGACGCGGCGACGGGTGCTGCCGGCATTGCGGCGCTGGAAGCCCATCCGGAGATCGCGGTGCTGTTTACCGATATCGTC
CTGGCCGGCGGCATGTCGGGCCTCGATCTCGCCATCGCCGCGCGCGCGGCGCGACCCGAGCTTCCGGTGCTGTTCACCTC
CGGCTATGGCGATCCCATCGTGCTGAAGGGCCGCGCCCTGCCCGCCGGGGCGATCTGGCTGCAGAAACCCTATGCCGAGG
CCGCCCTCGCGAACGCGCTGGCCGCCCTGCTCAGGCCGGTTCGCGACGAGGGCGTCTGA

Upstream 100 bases:

>100_bases
CGCGGCCGGTGGCGGCAATCCGCGGGCGGGGACGCCGCACCCGTTCGGGCCGCCGCAATTGCGCATCGACGCCAGACGCC
GCAGCGGGTAAAACCCCCTC

Downstream 100 bases:

>100_bases
CGCGCCGGGCGCGCTTCACCGCTCCAGCTTGCCGGCGAAGACATAGCCGGCGCCGCGCACCGTCTTGATCAGTTGCGGCT
GCCCGGGGTCCTGCTCGATC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MTPEPEAPDAPLAFARSFEAALIGKSLDGIITSWSEGAENLFGYRADEIIGRSIHVLAPPGREAEMDELLARTARGETFD
QFETIRRRKDGTLVRVLLTLNPVHDTEGCIVGISKIARDITEHRSTEARLRSILDTAPDAIVVIDPRGTVRSFSQAAERM
FGYAAEEVVGRNVSMLMAEPHAAAHDGYLARYLETGERRIIGIGREVEARRADGSTFPIELAVGEVDLPETRLFTGFIRD
ASKRKRLENDLAQAQKMEAVGQLTGGLAHDFNNLLAVISGNLEMLESHVAGGEAAELLAEARLATERGAELAARLLAFGR
RQTLRPLAIDVNELVGKMAPLFRRTLGSPVMIETRLAAGLPRTMADPGQIETALLNLALNARDAMPKGGRLVIETGLLHV
DADYAAQQAETLPGDYVVLAVTDSGIGMSAETRGRAFEPFFTTKAVGEGSGLGLSMVYGFVKQSGGHVQIYSEPGLGTTV
RLFLPAIRAEMPAADDEAAPSPPPGRAIVLVVEDDPAVRRVAERRLARLGYSTIDAATGAAGIAALEAHPEIAVLFTDIV
LAGGMSGLDLAIAARAARPELPVLFTSGYGDPIVLKGRALPAGAIWLQKPYAEAALANALAALLRPVRDEGV

Sequences:

>Translated_632_residues
MTPEPEAPDAPLAFARSFEAALIGKSLDGIITSWSEGAENLFGYRADEIIGRSIHVLAPPGREAEMDELLARTARGETFD
QFETIRRRKDGTLVRVLLTLNPVHDTEGCIVGISKIARDITEHRSTEARLRSILDTAPDAIVVIDPRGTVRSFSQAAERM
FGYAAEEVVGRNVSMLMAEPHAAAHDGYLARYLETGERRIIGIGREVEARRADGSTFPIELAVGEVDLPETRLFTGFIRD
ASKRKRLENDLAQAQKMEAVGQLTGGLAHDFNNLLAVISGNLEMLESHVAGGEAAELLAEARLATERGAELAARLLAFGR
RQTLRPLAIDVNELVGKMAPLFRRTLGSPVMIETRLAAGLPRTMADPGQIETALLNLALNARDAMPKGGRLVIETGLLHV
DADYAAQQAETLPGDYVVLAVTDSGIGMSAETRGRAFEPFFTTKAVGEGSGLGLSMVYGFVKQSGGHVQIYSEPGLGTTV
RLFLPAIRAEMPAADDEAAPSPPPGRAIVLVVEDDPAVRRVAERRLARLGYSTIDAATGAAGIAALEAHPEIAVLFTDIV
LAGGMSGLDLAIAARAARPELPVLFTSGYGDPIVLKGRALPAGAIWLQKPYAEAALANALAALLRPVRDEGV
>Mature_631_residues
TPEPEAPDAPLAFARSFEAALIGKSLDGIITSWSEGAENLFGYRADEIIGRSIHVLAPPGREAEMDELLARTARGETFDQ
FETIRRRKDGTLVRVLLTLNPVHDTEGCIVGISKIARDITEHRSTEARLRSILDTAPDAIVVIDPRGTVRSFSQAAERMF
GYAAEEVVGRNVSMLMAEPHAAAHDGYLARYLETGERRIIGIGREVEARRADGSTFPIELAVGEVDLPETRLFTGFIRDA
SKRKRLENDLAQAQKMEAVGQLTGGLAHDFNNLLAVISGNLEMLESHVAGGEAAELLAEARLATERGAELAARLLAFGRR
QTLRPLAIDVNELVGKMAPLFRRTLGSPVMIETRLAAGLPRTMADPGQIETALLNLALNARDAMPKGGRLVIETGLLHVD
ADYAAQQAETLPGDYVVLAVTDSGIGMSAETRGRAFEPFFTTKAVGEGSGLGLSMVYGFVKQSGGHVQIYSEPGLGTTVR
LFLPAIRAEMPAADDEAAPSPPPGRAIVLVVEDDPAVRRVAERRLARLGYSTIDAATGAAGIAALEAHPEIAVLFTDIVL
AGGMSGLDLAIAARAARPELPVLFTSGYGDPIVLKGRALPAGAIWLQKPYAEAALANALAALLRPVRDEGV

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=274, Percent_Identity=33.2116788321168, Blast_Score=119, Evalue=8e-28,
Organism=Escherichia coli, GI1788549, Length=369, Percent_Identity=27.10027100271, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788713, Length=485, Percent_Identity=24.3298969072165, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081921, Length=101, Percent_Identity=33.6633663366337, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790300, Length=359, Percent_Identity=23.9554317548747, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67442; Mature: 67311

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPEPEAPDAPLAFARSFEAALIGKSLDGIITSWSEGAENLFGYRADEIIGRSIHVLAPP
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCC
GREAEMDELLARTARGETFDQFETIRRRKDGTLVRVLLTLNPVHDTEGCIVGISKIARDI
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHH
TEHRSTEARLRSILDTAPDAIVVIDPRGTVRSFSQAAERMFGYAAEEVVGRNVSMLMAEP
HHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
HAAAHDGYLARYLETGERRIIGIGREVEARRADGSTFPIELAVGEVDLPETRLFTGFIRD
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ASKRKRLENDLAQAQKMEAVGQLTGGLAHDFNNLLAVISGNLEMLESHVAGGEAAELLAE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
ARLATERGAELAARLLAFGRRQTLRPLAIDVNELVGKMAPLFRRTLGSPVMIETRLAAGL
HHHHHHHHHHHHHHHHHHHCCCCCCHHEECHHHHHHHHHHHHHHHCCCCEEEEEHHHCCC
PRTMADPGQIETALLNLALNARDAMPKGGRLVIETGLLHVDADYAAQQAETLPGDYVVLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECEEEECCHHHHHHHHCCCCCEEEEE
VTDSGIGMSAETRGRAFEPFFTTKAVGEGSGLGLSMVYGFVKQSGGHVQIYSEPGLGTTV
EECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHH
RLFLPAIRAEMPAADDEAAPSPPPGRAIVLVVEDDPAVRRVAERRLARLGYSTIDAATGA
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCC
AGIAALEAHPEIAVLFTDIVLAGGMSGLDLAIAARAARPELPVLFTSGYGDPIVLKGRAL
CCEEEEECCCCEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCCEEEECCCC
PAGAIWLQKPYAEAALANALAALLRPVRDEGV
CCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPEPEAPDAPLAFARSFEAALIGKSLDGIITSWSEGAENLFGYRADEIIGRSIHVLAPP
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCC
GREAEMDELLARTARGETFDQFETIRRRKDGTLVRVLLTLNPVHDTEGCIVGISKIARDI
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEHHHHHHHH
TEHRSTEARLRSILDTAPDAIVVIDPRGTVRSFSQAAERMFGYAAEEVVGRNVSMLMAEP
HHHCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
HAAAHDGYLARYLETGERRIIGIGREVEARRADGSTFPIELAVGEVDLPETRLFTGFIRD
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
ASKRKRLENDLAQAQKMEAVGQLTGGLAHDFNNLLAVISGNLEMLESHVAGGEAAELLAE
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHH
ARLATERGAELAARLLAFGRRQTLRPLAIDVNELVGKMAPLFRRTLGSPVMIETRLAAGL
HHHHHHHHHHHHHHHHHHHCCCCCCHHEECHHHHHHHHHHHHHHHCCCCEEEEEHHHCCC
PRTMADPGQIETALLNLALNARDAMPKGGRLVIETGLLHVDADYAAQQAETLPGDYVVLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECEEEECCHHHHHHHHCCCCCEEEEE
VTDSGIGMSAETRGRAFEPFFTTKAVGEGSGLGLSMVYGFVKQSGGHVQIYSEPGLGTTV
EECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHH
RLFLPAIRAEMPAADDEAAPSPPPGRAIVLVVEDDPAVRRVAERRLARLGYSTIDAATGA
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHCCC
AGIAALEAHPEIAVLFTDIVLAGGMSGLDLAIAARAARPELPVLFTSGYGDPIVLKGRAL
CCEEEEECCCCEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCCCEEEECCCC
PAGAIWLQKPYAEAALANALAALLRPVRDEGV
CCCEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA