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The map label for this gene is icd [H]

Identifier: 148259581

GI number: 148259581

Start: 632365

End: 633594

Strand: Reverse

Name: icd [H]

Synonym: Acry_0565

Alternate gene names: 148259581

Gene position: 633594-632365 (Counterclockwise)

Preceding gene: 148259584

Following gene: 148259580

Centisome position: 18.69

GC content: 63.58

Gene sequence:

>1230_bases
ATGGCCAAGATCAAGGTTAAGAACCCGATCGTCGAGATGGACGGCGACGAGATGACCCGGATCATCTGGGGGTTCATCAA
GGACAAGCTGATCCTGCCCTATCTCGATGTCGACCTGAAATACTACGATCTCGGGATCGAGAACCGCGATGCCACGGACG
ACAAGGTGACGGTCGACTCGGCGCTGGCAACGAAGGAATACGGCGTCGCGGTGAAGTGCGCGACGATCACGCCGGACGAG
GCGCGCGTCAAGGAATTCAATCTCAAGCAGATGTGGCGCAGCCCGAACGGGACGATCCGCAACATCCTCGACGGCACGAT
CTTCCGCGAGCCGATCATCTGCGCGAACGTGCCGCGCCTGGTGCCGCACTGGTCGCAGCCGATCGTGATCGGCCGCCATG
CCTATGGCGACATCTACCGCGCCGCCGAAACCAAGATCCCCGGCCCGGGCAAGGTGCAGCTCTCCTACATCCCGGCCGAT
GGCAGCAAGCCGCTGATCCTCGACGTGCACGATTTCAAGGGCCCCGGCGTCGCGCTCGGCATCCACAACACCAAGGCCTC
GATCGAGGGCTTCGCGCGGGCGAGCTTCAATTACGGGCTGGCGCGGAACTATCCGGTCTATCTCTCGACCAAGAACACCA
TCCTCAAGGCCTATGACGGCATGTTCAAGGACGTGTTCCAGGAGATCTTCGACGCCGAGTTCAAGGCGGAGTTCGACAAG
CGCGGCCTGACCTACGAGCACCGGCTGATCGACGACATGGTCGCCTCGGCGCTGAAGTGGAACGGCGGCTATATCTGGGC
CTGCAAGAACTATGACGGCGATGTGGAGAGCGACATCGTCGCGCAGGGCTTCGGCAGCCTCGGGCTGATGACCTCGGTGC
TCATGAGCCCGGATGGCAAGACGGTGGAGAGCGAGGCGGCGCACGGCACCGTGACCCGCCACTATCGCGAGCACCAGAAG
GGCCGCCCGACCTCGACCAACCCGATCGCCTCGATCTTCGCGTGGACCCGCGGCCTCGCCTATCGCGGCAAGTTCGACGA
GACGCCCGAGGTGACCGAGTTCGCCGAGACGCTGGAGCGCGTCTGCGTCGAGACGGTGGAAAGCGGGTTCATGACCAAGG
ACCTCGCGCTGCTGATCTCGAAGGACCAGCCCTGGATGACCACGCAGGACTTCCTCGCCAAGCTCGACGAGAACCTGCAG
GCGGCGATGGCGAAGCGCCAGGCCGCGTGA

Upstream 100 bases:

>100_bases
CTGGCCGACGTCCTAGAACACCCCTGCCCTGCCGTCCACCGTCTTGCGGCGGGGCGGAGGCGTGGCTAGACCGGCTCAAA
CTGGCGCAAGGAGCTTCGGA

Downstream 100 bases:

>100_bases
TGGTGGGGCCCTGGGATCCATCCCCGGATCGCAGGGCCGCACACCGGACAGCATCATTGACTGAAAGACGGGGTGCCTTC
CCTATATGGGGATGATGGAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKIKVKNPIVEMDGDEMTRIIWGFIKDKLILPYLDVDLKYYDLGIENRDATDDKVTVDSALATKEYGVAVKCATITPDE
ARVKEFNLKQMWRSPNGTIRNILDGTIFREPIICANVPRLVPHWSQPIVIGRHAYGDIYRAAETKIPGPGKVQLSYIPAD
GSKPLILDVHDFKGPGVALGIHNTKASIEGFARASFNYGLARNYPVYLSTKNTILKAYDGMFKDVFQEIFDAEFKAEFDK
RGLTYEHRLIDDMVASALKWNGGYIWACKNYDGDVESDIVAQGFGSLGLMTSVLMSPDGKTVESEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLAYRGKFDETPEVTEFAETLERVCVETVESGFMTKDLALLISKDQPWMTTQDFLAKLDENLQ
AAMAKRQAA

Sequences:

>Translated_409_residues
MAKIKVKNPIVEMDGDEMTRIIWGFIKDKLILPYLDVDLKYYDLGIENRDATDDKVTVDSALATKEYGVAVKCATITPDE
ARVKEFNLKQMWRSPNGTIRNILDGTIFREPIICANVPRLVPHWSQPIVIGRHAYGDIYRAAETKIPGPGKVQLSYIPAD
GSKPLILDVHDFKGPGVALGIHNTKASIEGFARASFNYGLARNYPVYLSTKNTILKAYDGMFKDVFQEIFDAEFKAEFDK
RGLTYEHRLIDDMVASALKWNGGYIWACKNYDGDVESDIVAQGFGSLGLMTSVLMSPDGKTVESEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLAYRGKFDETPEVTEFAETLERVCVETVESGFMTKDLALLISKDQPWMTTQDFLAKLDENLQ
AAMAKRQAA
>Mature_408_residues
AKIKVKNPIVEMDGDEMTRIIWGFIKDKLILPYLDVDLKYYDLGIENRDATDDKVTVDSALATKEYGVAVKCATITPDEA
RVKEFNLKQMWRSPNGTIRNILDGTIFREPIICANVPRLVPHWSQPIVIGRHAYGDIYRAAETKIPGPGKVQLSYIPADG
SKPLILDVHDFKGPGVALGIHNTKASIEGFARASFNYGLARNYPVYLSTKNTILKAYDGMFKDVFQEIFDAEFKAEFDKR
GLTYEHRLIDDMVASALKWNGGYIWACKNYDGDVESDIVAQGFGSLGLMTSVLMSPDGKTVESEAAHGTVTRHYREHQKG
RPTSTNPIASIFAWTRGLAYRGKFDETPEVTEFAETLERVCVETVESGFMTKDLALLISKDQPWMTTQDFLAKLDENLQA
AMAKRQAA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=410, Percent_Identity=64.6341463414634, Blast_Score=569, Evalue=1e-162,
Organism=Homo sapiens, GI28178825, Length=411, Percent_Identity=62.7737226277372, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17540874, Length=416, Percent_Identity=63.2211538461538, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17550822, Length=408, Percent_Identity=62.0098039215686, Blast_Score=541, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320137, Length=405, Percent_Identity=63.2098765432099, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=63.6138613861386, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=62.1621621621622, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI21356561, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221330987, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI221330985, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI28574947, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24660849, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24660856, Length=417, Percent_Identity=60.6714628297362, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI221330983, Length=417, Percent_Identity=60.6714628297362, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24660868, Length=417, Percent_Identity=60.6714628297362, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24660860, Length=417, Percent_Identity=60.6714628297362, Blast_Score=532, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45769; Mature: 45637

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVKNPIVEMDGDEMTRIIWGFIKDKLILPYLDVDLKYYDLGIENRDATDDKVTVDS
CCEEEECCCEEECCCHHHHHHHHHHHHCCEECEEECCCEEEEEECCCCCCCCCCEEEEHH
ALATKEYGVAVKCATITPDEARVKEFNLKQMWRSPNGTIRNILDGTIFREPIICANVPRL
HHHHHCCCEEEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHCCHHHCCCCCCCCCCHH
VPHWSQPIVIGRHAYGDIYRAAETKIPGPGKVQLSYIPADGSKPLILDVHDFKGPGVALG
CCCCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEE
IHNTKASIEGFARASFNYGLARNYPVYLSTKNTILKAYDGMFKDVFQEIFDAEFKAEFDK
ECCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RGLTYEHRLIDDMVASALKWNGGYIWACKNYDGDVESDIVAQGFGSLGLMTSVLMSPDGK
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCC
TVESEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLAYRGKFDETPEVTEFAETLER
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHH
VCVETVESGFMTKDLALLISKDQPWMTTQDFLAKLDENLQAAMAKRQAA
HHHHHHHCCCCHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKIKVKNPIVEMDGDEMTRIIWGFIKDKLILPYLDVDLKYYDLGIENRDATDDKVTVDS
CEEEECCCEEECCCHHHHHHHHHHHHCCEECEEECCCEEEEEECCCCCCCCCCEEEEHH
ALATKEYGVAVKCATITPDEARVKEFNLKQMWRSPNGTIRNILDGTIFREPIICANVPRL
HHHHHCCCEEEEEEEECCCHHHHHHCCHHHHHCCCCCHHHHHHCCHHHCCCCCCCCCCHH
VPHWSQPIVIGRHAYGDIYRAAETKIPGPGKVQLSYIPADGSKPLILDVHDFKGPGVALG
CCCCCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEE
IHNTKASIEGFARASFNYGLARNYPVYLSTKNTILKAYDGMFKDVFQEIFDAEFKAEFDK
ECCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
RGLTYEHRLIDDMVASALKWNGGYIWACKNYDGDVESDIVAQGFGSLGLMTSVLMSPDGK
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCC
TVESEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLAYRGKFDETPEVTEFAETLER
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEECCCCCCCCCHHHHHHHHHH
VCVETVESGFMTKDLALLISKDQPWMTTQDFLAKLDENLQAAMAKRQAA
HHHHHHHCCCCHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]