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The map label for this gene is mrdA [H]

Identifier: 148259513

GI number: 148259513

Start: 552015

End: 553919

Strand: Reverse

Name: mrdA [H]

Synonym: Acry_0497

Alternate gene names: 148259513

Gene position: 553919-552015 (Counterclockwise)

Preceding gene: 148259517

Following gene: 148259512

Centisome position: 16.34

GC content: 68.56

Gene sequence:

>1905_bases
GTGAGACCGGCAACGATCATCGAACCGTGTCTTGGCACCGGCCGCGGCGCGAGGCAGACCGCCCGCATGAACGCGCAACG
CGACAAGAAGCAGCGTGCCGTCTTCACCCGGCGCGCCATGATCATCGGAGGCAGCCAGGTCGCGCTGTTCTCGGCGCTGA
CCGCGCGACTCTACGAGATGGAGATCGTCGATCACAGCCGCTACAGCCGGCTCGCCCGCAAGAACGCGGTGAGCGAACGG
CTGATCGCGCCGGAACGCGGACTGATCACTGACCGCAACGGCATCATTCTGGCCGGCAATCGCCAGCAATGGCAGGCCCT
GTTCCTGATGACGGCGGCGTCTGACCCTGCCGCCACGATCGCGCGCCTGGAACGGATCGTGTCGCTGTCGCCGGCCGATC
GCGCCCGGCTTGCGAAACTCGCCACCGGGCCGATCCATTTCCTGCCGATCCTCGTCAAGAAGGATCTCGGCTGGGACGAG
ATGGCCAGACTCGAAGTTCACAGGCCATCGCTGCCCGGCCTCATCATCGATCGCGGCTTCCGGCGATTCTACCCGCTCGG
CCCGCTTACCGCCCATCCGGTGGGCTACGTCGTCCGCCCGGACAGCGCCGATGCGGGGCGCGAGCCGGTTCTCGCCCTGC
CGGGTGTGCGCGTCGGCGGCAGCGGCATCGAAAAATCGGCCAATGCCGCGCTCTTCGGATCGCCCGGCATCGTCGAGGAT
GAGGTCGACGCCGGCGGGGCCGTCGTTCGTGTCATCACGCGACGCCCGGCGCGCGAGGGGCACGCCGTCGGTCTCACCCT
CGATGCCGGATTGCAGCGCACCGCTGCCGGCGCCCTGAACGGGCGGCCCGGCGCCGCGGTGCTGATCGACACCAGCACAG
GCGACCTGCTCGCCATGGCCAGCGCGCCCTCGTTCGACCCGACCTGGTTCGACGACGGTGTGCCCGATCATGTCTGGCGG
CGCTGGACCTCGAAGGCGGCGCATCATCCGCTTACTGACCGTGCGACCGGCGGACTCTATGCCCCGGGCTCATCCTTCAA
GCCGACCGTCGCCCTCGCCGCACTCGAAGCCGGCGCGATCACCGGCGACACAAGGTTCTTCTGTTCCGGACACATGAAGA
TCGGCAACCGGATCTTCTATTGCTGGCTCCGCTCCGGCCACGGCTCGATGGACGTCGCCTCGGCCCTGCAGCAGAGCTGC
GACATTTTTTTCTACCACGTCGCGATGCGCACCGGAATCGACCGGATGGCCGCGATGGCCCGGCATCTCGGCCTGACGGG
CCGCGAAGCGCTCGCCCTGCCGAATGTCGCCGAAGGCTTCATCCCGACGCGCCGATGGGCGAAACAGCGGCAAATCGACT
GGACCAAGGGCGATACGGCGGTTCAGGGGATCGGTCAGGGCTACACCGTCCTGACGCCGCTCGCACTCGCCGTGATGGCG
GCACGCATCGGCACCGGCCGGGCGGTTCGCCCGCGAATCATCCGGACGGTCGGAGCGGTCGAGCGAACCCATCCGGCGGC
AACCACGCTCTCCCTTTCGGATCGTCACCTGGCCCTGGTCCGCCAGGGTATGGCGGAGGTGGTCAACACGCCCCTCGGCA
CCGCCTGGGGCGCCCGCCTCGCGCTCCGGGGTGCCAGGATGGCCGGCAAGACGGGCACGGCCCAGGTCATCGGGGAAAGC
GCCGAGATGGAAGCCGAAAACTACAACGATGCCGAACTGCCGTGGCAGGACCGGCCGAATGCGCTGTTCGTGGGCTACGC
GCCGCTCGACAGGCCACGTTTCGCTGCGGCCGTGGTGATCGAGCATGGCACGCTTCTCGGCCCCGTGAAGATCGCCCGGG
ACCTGTTCGCGGCCGCCCTCTCCCGACGCCGTCTCGCCTATGGCGACGAGTCCAGACCTGCGTGA

Upstream 100 bases:

>100_bases
CCAGGTCACATGCCCTTGCACGCCGGCCGCCCGGTGCGAAACCCTGCCATGCCACATATGGCGAACCGCCCCGTTTCACG
CGGCGGGGAGTCAAAGGCGC

Downstream 100 bases:

>100_bases
TGCGGATCGCTCCGGGCATCGTATCGTCCCGTTGCCGATCATGACATCAGGATCCGCGGCCGCAGGTTCACGCCCGCTGC
TTCAAGATACGGTGATACAA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MRPATIIEPCLGTGRGARQTARMNAQRDKKQRAVFTRRAMIIGGSQVALFSALTARLYEMEIVDHSRYSRLARKNAVSER
LIAPERGLITDRNGIILAGNRQQWQALFLMTAASDPAATIARLERIVSLSPADRARLAKLATGPIHFLPILVKKDLGWDE
MARLEVHRPSLPGLIIDRGFRRFYPLGPLTAHPVGYVVRPDSADAGREPVLALPGVRVGGSGIEKSANAALFGSPGIVED
EVDAGGAVVRVITRRPAREGHAVGLTLDAGLQRTAAGALNGRPGAAVLIDTSTGDLLAMASAPSFDPTWFDDGVPDHVWR
RWTSKAAHHPLTDRATGGLYAPGSSFKPTVALAALEAGAITGDTRFFCSGHMKIGNRIFYCWLRSGHGSMDVASALQQSC
DIFFYHVAMRTGIDRMAAMARHLGLTGREALALPNVAEGFIPTRRWAKQRQIDWTKGDTAVQGIGQGYTVLTPLALAVMA
ARIGTGRAVRPRIIRTVGAVERTHPAATTLSLSDRHLALVRQGMAEVVNTPLGTAWGARLALRGARMAGKTGTAQVIGES
AEMEAENYNDAELPWQDRPNALFVGYAPLDRPRFAAAVVIEHGTLLGPVKIARDLFAAALSRRRLAYGDESRPA

Sequences:

>Translated_634_residues
MRPATIIEPCLGTGRGARQTARMNAQRDKKQRAVFTRRAMIIGGSQVALFSALTARLYEMEIVDHSRYSRLARKNAVSER
LIAPERGLITDRNGIILAGNRQQWQALFLMTAASDPAATIARLERIVSLSPADRARLAKLATGPIHFLPILVKKDLGWDE
MARLEVHRPSLPGLIIDRGFRRFYPLGPLTAHPVGYVVRPDSADAGREPVLALPGVRVGGSGIEKSANAALFGSPGIVED
EVDAGGAVVRVITRRPAREGHAVGLTLDAGLQRTAAGALNGRPGAAVLIDTSTGDLLAMASAPSFDPTWFDDGVPDHVWR
RWTSKAAHHPLTDRATGGLYAPGSSFKPTVALAALEAGAITGDTRFFCSGHMKIGNRIFYCWLRSGHGSMDVASALQQSC
DIFFYHVAMRTGIDRMAAMARHLGLTGREALALPNVAEGFIPTRRWAKQRQIDWTKGDTAVQGIGQGYTVLTPLALAVMA
ARIGTGRAVRPRIIRTVGAVERTHPAATTLSLSDRHLALVRQGMAEVVNTPLGTAWGARLALRGARMAGKTGTAQVIGES
AEMEAENYNDAELPWQDRPNALFVGYAPLDRPRFAAAVVIEHGTLLGPVKIARDLFAAALSRRRLAYGDESRPA
>Mature_634_residues
MRPATIIEPCLGTGRGARQTARMNAQRDKKQRAVFTRRAMIIGGSQVALFSALTARLYEMEIVDHSRYSRLARKNAVSER
LIAPERGLITDRNGIILAGNRQQWQALFLMTAASDPAATIARLERIVSLSPADRARLAKLATGPIHFLPILVKKDLGWDE
MARLEVHRPSLPGLIIDRGFRRFYPLGPLTAHPVGYVVRPDSADAGREPVLALPGVRVGGSGIEKSANAALFGSPGIVED
EVDAGGAVVRVITRRPAREGHAVGLTLDAGLQRTAAGALNGRPGAAVLIDTSTGDLLAMASAPSFDPTWFDDGVPDHVWR
RWTSKAAHHPLTDRATGGLYAPGSSFKPTVALAALEAGAITGDTRFFCSGHMKIGNRIFYCWLRSGHGSMDVASALQQSC
DIFFYHVAMRTGIDRMAAMARHLGLTGREALALPNVAEGFIPTRRWAKQRQIDWTKGDTAVQGIGQGYTVLTPLALAVMA
ARIGTGRAVRPRIIRTVGAVERTHPAATTLSLSDRHLALVRQGMAEVVNTPLGTAWGARLALRGARMAGKTGTAQVIGES
AEMEAENYNDAELPWQDRPNALFVGYAPLDRPRFAAAVVIEHGTLLGPVKIARDLFAAALSRRRLAYGDESRPA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=595, Percent_Identity=33.2773109243697, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1786272, Length=603, Percent_Identity=26.3681592039801, Blast_Score=126, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 68274; Mature: 68274

Theoretical pI: Translated: 10.84; Mature: 10.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPATIIEPCLGTGRGARQTARMNAQRDKKQRAVFTRRAMIIGGSQVALFSALTARLYEM
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHH
EIVDHSRYSRLARKNAVSERLIAPERGLITDRNGIILAGNRQQWQALFLMTAASDPAATI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCCEEEEEEEEECCCHHHHH
ARLERIVSLSPADRARLAKLATGPIHFLPILVKKDLGWDEMARLEVHRPSLPGLIIDRGF
HHHHHHHCCCCCHHHHHHHHCCCCHHEEEEEEECCCCHHHHHHEEEECCCCCCHHHHCCH
RRFYPLGPLTAHPVGYVVRPDSADAGREPVLALPGVRVGGSGIEKSANAALFGSPGIVED
HHHCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCEECCCCCCCCCCEEEECCCCCCCC
EVDAGGAVVRVITRRPAREGHAVGLTLDAGLQRTAAGALNGRPGAAVLIDTSTGDLLAMA
CCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHCCCCCCCCEEEEEECCCCCEEEEE
SAPSFDPTWFDDGVPDHVWRRWTSKAAHHPLTDRATGGLYAPGSSFKPTVALAALEAGAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEEEEEHHCCCC
TGDTRFFCSGHMKIGNRIFYCWLRSGHGSMDVASALQQSCDIFFYHVAMRTGIDRMAAMA
CCCCEEEEECCEECCCEEEEEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHCHHHHHHHH
RHLGLTGREALALPNVAEGFIPTRRWAKQRQIDWTKGDTAVQGIGQGYTVLTPLALAVMA
HHCCCCCCHHCCCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
ARIGTGRAVRPRIIRTVGAVERTHPAATTLSLSDRHLALVRQGMAEVVNTPLGTAWGARL
HHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHH
ALRGARMAGKTGTAQVIGESAEMEAENYNDAELPWQDRPNALFVGYAPLDRPRFAAAVVI
HHHHHHHCCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEE
EHGTLLGPVKIARDLFAAALSRRRLAYGDESRPA
ECCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRPATIIEPCLGTGRGARQTARMNAQRDKKQRAVFTRRAMIIGGSQVALFSALTARLYEM
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHH
EIVDHSRYSRLARKNAVSERLIAPERGLITDRNGIILAGNRQQWQALFLMTAASDPAATI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEECCCCCEEEEEEEEECCCHHHHH
ARLERIVSLSPADRARLAKLATGPIHFLPILVKKDLGWDEMARLEVHRPSLPGLIIDRGF
HHHHHHHCCCCCHHHHHHHHCCCCHHEEEEEEECCCCHHHHHHEEEECCCCCCHHHHCCH
RRFYPLGPLTAHPVGYVVRPDSADAGREPVLALPGVRVGGSGIEKSANAALFGSPGIVED
HHHCCCCCCCCCCCEEEECCCCCCCCCCCEEECCCCEECCCCCCCCCCEEEECCCCCCCC
EVDAGGAVVRVITRRPAREGHAVGLTLDAGLQRTAAGALNGRPGAAVLIDTSTGDLLAMA
CCCCCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHCCCCCCCCEEEEEECCCCCEEEEE
SAPSFDPTWFDDGVPDHVWRRWTSKAAHHPLTDRATGGLYAPGSSFKPTVALAALEAGAI
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCEEEEEHHCCCC
TGDTRFFCSGHMKIGNRIFYCWLRSGHGSMDVASALQQSCDIFFYHVAMRTGIDRMAAMA
CCCCEEEEECCEECCCEEEEEEEECCCCCHHHHHHHHHHCCEEEEHHHHHHCHHHHHHHH
RHLGLTGREALALPNVAEGFIPTRRWAKQRQIDWTKGDTAVQGIGQGYTVLTPLALAVMA
HHCCCCCCHHCCCCCHHHCCCCHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
ARIGTGRAVRPRIIRTVGAVERTHPAATTLSLSDRHLALVRQGMAEVVNTPLGTAWGARL
HHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHH
ALRGARMAGKTGTAQVIGESAEMEAENYNDAELPWQDRPNALFVGYAPLDRPRFAAAVVI
HHHHHHHCCCCCCHHHHCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEE
EHGTLLGPVKIARDLFAAALSRRRLAYGDESRPA
ECCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]