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The map label for this gene is livH [H]

Identifier: 148259376

GI number: 148259376

Start: 407302

End: 408204

Strand: Reverse

Name: livH [H]

Synonym: Acry_0359

Alternate gene names: 148259376

Gene position: 408204-407302 (Counterclockwise)

Preceding gene: 148259377

Following gene: 148259375

Centisome position: 12.04

GC content: 65.56

Gene sequence:

>903_bases
ATGGGAACGTTCATCCAGCAGGTCTTCAACGGCCTGACGGTCGGGGGCATCTACGCGCTCATCGCGCTGGGCTACACGAT
GGTTTATGGCGTGATGCGCCTGATCAATTTCGCCCATGGCGATCTCTGCATCCTCGGCGCCTTCATCGGCCTCACCTTCC
TCACCTCGCTCGGCGGTGCCGGCCATCCCGGCGCAGCCCTGCTGATCCTCGCCTTCGTCGCGGCGATCGTGGTGGTGGCG
GTGGCCGGCGTCGTGCTCGAACTCGCCGCCTACCGGCCGCTGCGCAAGGCGGATCGCCTCGCCGCCGTGGTCTCGGCACT
TGGCGCGTCATTGCTGATCGAGAACGGAATCATGCTGATCTGGAGCCCCCAGGTCAGCGTGTTCCCCTCGGGCCTGCTGC
CGACGACGACCTATCACATCGCCGGCGCCTCGATCAGCTTCGTGCAGGTGATGATCATCATCGTCTCCTTCCTGCTGATG
GCGGCGCTCTACCTGTTCGTGAACCACACCCGCTTCGGCACCGCGATCCGCGCCGCGGCGATCGACCAGGACGCCGCGCG
GCTGATGGGCATCAACGTCAACCGAGTGATCGCCAGCGTCTTCGTCATCGGCCCGGCGCTCGGCGCGGTGGGCGGGCTGT
TCATCGGCGTCTATTACCGCGAAGTCTATTTCACCATGGGCTGGACCTACGGGCTCTACGCCTTCATCGCCGCCATTCTC
GGCGGCATCGGCAACATTCCGGGGGCGATGCTGGGCGGCATCCTGCTCGGCCTCTTCAACGCCTTCGCCGCCGGCTACAT
CTCCAGCTCCTGGCAGGATGCGATCACCTTCGCGCTGCTGATCGGGATCCTGCTGGTGCGGCCTTCTGGACTCCTGGGCG
AACGCGTCGCGGAGAAGGTGTGA

Upstream 100 bases:

>100_bases
TTCACCGCCTTCGAGGTGCAGGCCGACGGCAGCTACAAGATCGTCTATCCGGCGCCCAAGGCCGGCTGACGGGCCGGTCG
CGCCGGGGGGAGGTTTCGTC

Downstream 100 bases:

>100_bases
TGAGCGCATCCGCAAGCCGCAACACCGGCATCGCCGTCTGGATCCTCGGCCTGTTTCTGCCGGTCGTGCTGAACAGCGCC
TGGGTCTCGGTTGCCGCGAT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGTFIQQVFNGLTVGGIYALIALGYTMVYGVMRLINFAHGDLCILGAFIGLTFLTSLGGAGHPGAALLILAFVAAIVVVA
VAGVVLELAAYRPLRKADRLAAVVSALGASLLIENGIMLIWSPQVSVFPSGLLPTTTYHIAGASISFVQVMIIIVSFLLM
AALYLFVNHTRFGTAIRAAAIDQDAARLMGINVNRVIASVFVIGPALGAVGGLFIGVYYREVYFTMGWTYGLYAFIAAIL
GGIGNIPGAMLGGILLGLFNAFAAGYISSSWQDAITFALLIGILLVRPSGLLGERVAEKV

Sequences:

>Translated_300_residues
MGTFIQQVFNGLTVGGIYALIALGYTMVYGVMRLINFAHGDLCILGAFIGLTFLTSLGGAGHPGAALLILAFVAAIVVVA
VAGVVLELAAYRPLRKADRLAAVVSALGASLLIENGIMLIWSPQVSVFPSGLLPTTTYHIAGASISFVQVMIIIVSFLLM
AALYLFVNHTRFGTAIRAAAIDQDAARLMGINVNRVIASVFVIGPALGAVGGLFIGVYYREVYFTMGWTYGLYAFIAAIL
GGIGNIPGAMLGGILLGLFNAFAAGYISSSWQDAITFALLIGILLVRPSGLLGERVAEKV
>Mature_299_residues
GTFIQQVFNGLTVGGIYALIALGYTMVYGVMRLINFAHGDLCILGAFIGLTFLTSLGGAGHPGAALLILAFVAAIVVVAV
AGVVLELAAYRPLRKADRLAAVVSALGASLLIENGIMLIWSPQVSVFPSGLLPTTTYHIAGASISFVQVMIIIVSFLLMA
ALYLFVNHTRFGTAIRAAAIDQDAARLMGINVNRVIASVFVIGPALGAVGGLFIGVYYREVYFTMGWTYGLYAFIAAILG
GIGNIPGAMLGGILLGLFNAFAAGYISSSWQDAITFALLIGILLVRPSGLLGERVAEKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=301, Percent_Identity=44.5182724252492, Blast_Score=223, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 31380; Mature: 31249

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTFIQQVFNGLTVGGIYALIALGYTMVYGVMRLINFAHGDLCILGAFIGLTFLTSLGGA
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GHPGAALLILAFVAAIVVVAVAGVVLELAAYRPLRKADRLAAVVSALGASLLIENGIMLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
WSPQVSVFPSGLLPTTTYHIAGASISFVQVMIIIVSFLLMAALYLFVNHTRFGTAIRAAA
ECCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDQDAARLMGINVNRVIASVFVIGPALGAVGGLFIGVYYREVYFTMGWTYGLYAFIAAIL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGIGNIPGAMLGGILLGLFNAFAAGYISSSWQDAITFALLIGILLVRPSGLLGERVAEKV
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
GTFIQQVFNGLTVGGIYALIALGYTMVYGVMRLINFAHGDLCILGAFIGLTFLTSLGGA
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GHPGAALLILAFVAAIVVVAVAGVVLELAAYRPLRKADRLAAVVSALGASLLIENGIMLI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
WSPQVSVFPSGLLPTTTYHIAGASISFVQVMIIIVSFLLMAALYLFVNHTRFGTAIRAAA
ECCCHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDQDAARLMGINVNRVIASVFVIGPALGAVGGLFIGVYYREVYFTMGWTYGLYAFIAAIL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGIGNIPGAMLGGILLGLFNAFAAGYISSSWQDAITFALLIGILLVRPSGLLGERVAEKV
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]