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The map label for this gene is fabH

Identifier: 148259289

GI number: 148259289

Start: 309567

End: 310529

Strand: Reverse

Name: fabH

Synonym: Acry_0269

Alternate gene names: 148259289

Gene position: 310529-309567 (Counterclockwise)

Preceding gene: 148259290

Following gene: 148259288

Centisome position: 9.16

GC content: 70.3

Gene sequence:

>963_bases
ATGCAACGCACCGTTCTCGAAGGGGTCGGCAGCTACCTGCCGGAACGCATCGTCACCAATCACGAGCTCGCGACGCGGAT
CGACACGTCCGACGCGTGGATCCGCGAGCGCACCGGGATCGGCCAGCGGCACATCGCCGCCGCGCATGAAACCGCGACCT
TCATGGGCGCCGAGGCGGCGCGGCGAGCACTTGCCGCCGCCGGCGCTTCGGCGGATTCGGTCGATGCCGTCATCGTCGCG
ACGTCCACGCCGGACCAGGGCTTTCCGGCCACCGCGGTGAGCATCCAGGCCGCCATCGGCATGACGCGCGGCTTCGCCTT
CGATCTCTCGGCGGCCTGCTCGGGCTTCGTCTACGGCGTTTCGGTGGCCGATGCGATGATCCGCGCCGGGCAATGCCGCA
GCGCGCTGGTGATCGGCACCGAAGTCTATTCGCGCATCCTCAACTGGGAGGACCGGGGCACCTGCGTGCTGTTCGGCGAC
GGCGCCGGCGCCGTGCTGCTGCGCGCCGGCACCGGCGAGGACGATCGTGGCGTGATCTCCACCCATATCCATTCCGACGG
GCGCTACGGCGACATCCTCTTCATCGACGGGGCGACCGGCCAGGACGACCGGCCGCAGCACCTCGTGATGAACGGGCGCG
AGGTGTTCCGCCACGCCGTCAGCAAGCTCGCCGGCGCGGTCGACGAGGCGCTGGCGGCCAACGATCTGACCCAGGCGGAT
ATCGACTGGCTGGTGCCGCACCAGGCCAACCGGCGAATCATCGACGCGATGGGCAAGCGGCTCGGCCTCGCGCCGGAGCA
GGTCGTGGTCACGGTTGACCGGCACGCCAATACCTCCGCCGCGTCGATCCCGCTCGCGCTGGACGAGGCGGTGCGCGACG
GGCGCATCCGTCGCGGCCATCTCGTGCTGATCGAGGCGCTTGGCGGCGGGCTGACCTGGGGTTCGGCGCTGATCCGCTTC
TGA

Upstream 100 bases:

>100_bases
ACGATCTCGGCCGCCACGCCGACCGCGAACGCCTCGCCAGCGACGCGTTCCGCGCCACACCGCCCGCTTCCGCCACCTCC
GTGACAACCGGCTGACCGAC

Downstream 100 bases:

>100_bases
ACCGCCGGCGCGCATGGCTCCGGCCGCTGCCCGCAGCCTGTTCCGTGTTGACCCGACAGGCTTTCTTGCTAATCTTGAAA
AATGAGCACGTTGACACGCG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MQRTVLEGVGSYLPERIVTNHELATRIDTSDAWIRERTGIGQRHIAAAHETATFMGAEAARRALAAAGASADSVDAVIVA
TSTPDQGFPATAVSIQAAIGMTRGFAFDLSAACSGFVYGVSVADAMIRAGQCRSALVIGTEVYSRILNWEDRGTCVLFGD
GAGAVLLRAGTGEDDRGVISTHIHSDGRYGDILFIDGATGQDDRPQHLVMNGREVFRHAVSKLAGAVDEALAANDLTQAD
IDWLVPHQANRRIIDAMGKRLGLAPEQVVVTVDRHANTSAASIPLALDEAVRDGRIRRGHLVLIEALGGGLTWGSALIRF

Sequences:

>Translated_320_residues
MQRTVLEGVGSYLPERIVTNHELATRIDTSDAWIRERTGIGQRHIAAAHETATFMGAEAARRALAAAGASADSVDAVIVA
TSTPDQGFPATAVSIQAAIGMTRGFAFDLSAACSGFVYGVSVADAMIRAGQCRSALVIGTEVYSRILNWEDRGTCVLFGD
GAGAVLLRAGTGEDDRGVISTHIHSDGRYGDILFIDGATGQDDRPQHLVMNGREVFRHAVSKLAGAVDEALAANDLTQAD
IDWLVPHQANRRIIDAMGKRLGLAPEQVVVTVDRHANTSAASIPLALDEAVRDGRIRRGHLVLIEALGGGLTWGSALIRF
>Mature_320_residues
MQRTVLEGVGSYLPERIVTNHELATRIDTSDAWIRERTGIGQRHIAAAHETATFMGAEAARRALAAAGASADSVDAVIVA
TSTPDQGFPATAVSIQAAIGMTRGFAFDLSAACSGFVYGVSVADAMIRAGQCRSALVIGTEVYSRILNWEDRGTCVLFGD
GAGAVLLRAGTGEDDRGVISTHIHSDGRYGDILFIDGATGQDDRPQHLVMNGREVFRHAVSKLAGAVDEALAANDLTQAD
IDWLVPHQANRRIIDAMGKRLGLAPEQVVVTVDRHANTSAASIPLALDEAVRDGRIRRGHLVLIEALGGGLTWGSALIRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=53.1446540880503, Blast_Score=340, Evalue=6e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ACICJ (A5FV65)

Other databases:

- EMBL:   CP000697
- RefSeq:   YP_001233416.1
- ProteinModelPortal:   A5FV65
- SMR:   A5FV65
- STRING:   A5FV65
- GeneID:   5160307
- GenomeReviews:   CP000697_GR
- KEGG:   acr:Acry_0269
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   NARILHA
- ProtClustDB:   CLSK935911
- BioCyc:   ACRY349163:ACRY_0269-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33875; Mature: 33875

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 247-247 ACT_SITE 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTVLEGVGSYLPERIVTNHELATRIDTSDAWIRERTGIGQRHIAAAHETATFMGAEAA
CCCHHHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRALAAAGASADSVDAVIVATSTPDQGFPATAVSIQAAIGMTRGFAFDLSAACSGFVYGV
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHCCCEEHH
SVADAMIRAGQCRSALVIGTEVYSRILNWEDRGTCVLFGDGAGAVLLRAGTGEDDRGVIS
HHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEE
THIHSDGRYGDILFIDGATGQDDRPQHLVMNGREVFRHAVSKLAGAVDEALAANDLTQAD
EEEECCCCEEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IDWLVPHQANRRIIDAMGKRLGLAPEQVVVTVDRHANTSAASIPLALDEAVRDGRIRRGH
CCEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
LVLIEALGGGLTWGSALIRF
EEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MQRTVLEGVGSYLPERIVTNHELATRIDTSDAWIRERTGIGQRHIAAAHETATFMGAEAA
CCCHHHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRALAAAGASADSVDAVIVATSTPDQGFPATAVSIQAAIGMTRGFAFDLSAACSGFVYGV
HHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHCCCEEHH
SVADAMIRAGQCRSALVIGTEVYSRILNWEDRGTCVLFGDGAGAVLLRAGTGEDDRGVIS
HHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEE
THIHSDGRYGDILFIDGATGQDDRPQHLVMNGREVFRHAVSKLAGAVDEALAANDLTQAD
EEEECCCCEEEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IDWLVPHQANRRIIDAMGKRLGLAPEQVVVTVDRHANTSAASIPLALDEAVRDGRIRRGH
CCEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
LVLIEALGGGLTWGSALIRF
EEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA