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The map label for this gene is fghA [H]

Identifier: 148259023

GI number: 148259023

Start: 1737

End: 2588

Strand: Reverse

Name: fghA [H]

Synonym: Acry_0002

Alternate gene names: 148259023

Gene position: 2588-1737 (Counterclockwise)

Preceding gene: 148259029

Following gene: NA

Centisome position: 0.08

GC content: 65.14

Gene sequence:

>852_bases
ATGACCAGCGCCACCGTTCTTGAGACGGTTTCGACCCAGAAATGTTTTGGCGGCATGCAGGGCGTTTATCGGCATGAGGC
AAAGGAGACCGGCTGCACAATGCGATTCGCCGTTTTCCTGCCGCCGCAGGCCGCGGCGGGAACGGTTCCTGCGCTCTATT
ATCTGGCCGGGCTGACCTGCACCGAGGAGAATTTCACGGTGAAGGCCGGGGCGCAGCGCGTGGCCGCGGAACTCGGCATC
GCCCTGATCGCGCCGGATACCTCCCCGCGAGGCCTCGGTTATCCTGGCGAGGACGACGCCTATGATTTCGGCACCGGCGC
CGGTTTCTATGTCGATGCGACGGAAACGCCGTGGCGGGACGGCTACCGGATGTATTCCTACATCACGAGGGAACTCCCTG
CCCTCATCAACGCGTCCTTTCCGGTCGATCCCGCGCGCGTGGGCATTTTCGGCCATTCGATGGGTGGGCATGGCGCGCTG
ACGATCGCGCTGAAGAACCCTGGCGCCTACCGCTCGGTCTCGGCCTTCGCGCCGATCGTCTCGCCGATGCGCTGCCCCTG
GGGTGAAAAGGCGCTGACCGGCTATCTCGGCGTCGACCGTGCGAACTGGCGCGCCTATGACGCGACGGCGCTGATCGAGG
ACCGCGGCTGGGCAGGGCCGGCCATCCTCGTCGACCAGGGCACCGCCGATCCGTTTCTCGAACGCGAGCTGAAACCGGAA
CTGCTCCGCGAGGCCTGCGCGGCGAAGGGCGTGAAGCTCGATCTGCGGATGCAGGAGGGGTACGACCACTCCTACTTCTT
CATCGCGACCTTCGTGGAAGACCATCTGCGCCATCACGCCCGCCATCTCTGA

Upstream 100 bases:

>100_bases
ATGCGTTTAAATTCGATAAAGCGCATATCGGCGCAGACTGATTGCCTTCCATCCACCTGCGCGGGATAGTTGTGCGCATG
ATTCAAAGGGAGATCGATAC

Downstream 100 bases:

>100_bases
CAGGCGGCGACGCTGCCCGGATCCGGCTCAGACGGTCAGGATCCGGCGCAGCAGTTCGACATCCTCGGCGAAATCGGGAT
CGGCCTCGATCAGTTCGGTC

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTSATVLETVSTQKCFGGMQGVYRHEAKETGCTMRFAVFLPPQAAAGTVPALYYLAGLTCTEENFTVKAGAQRVAAELGI
ALIAPDTSPRGLGYPGEDDAYDFGTGAGFYVDATETPWRDGYRMYSYITRELPALINASFPVDPARVGIFGHSMGGHGAL
TIALKNPGAYRSVSAFAPIVSPMRCPWGEKALTGYLGVDRANWRAYDATALIEDRGWAGPAILVDQGTADPFLERELKPE
LLREACAAKGVKLDLRMQEGYDHSYFFIATFVEDHLRHHARHL

Sequences:

>Translated_283_residues
MTSATVLETVSTQKCFGGMQGVYRHEAKETGCTMRFAVFLPPQAAAGTVPALYYLAGLTCTEENFTVKAGAQRVAAELGI
ALIAPDTSPRGLGYPGEDDAYDFGTGAGFYVDATETPWRDGYRMYSYITRELPALINASFPVDPARVGIFGHSMGGHGAL
TIALKNPGAYRSVSAFAPIVSPMRCPWGEKALTGYLGVDRANWRAYDATALIEDRGWAGPAILVDQGTADPFLERELKPE
LLREACAAKGVKLDLRMQEGYDHSYFFIATFVEDHLRHHARHL
>Mature_282_residues
TSATVLETVSTQKCFGGMQGVYRHEAKETGCTMRFAVFLPPQAAAGTVPALYYLAGLTCTEENFTVKAGAQRVAAELGIA
LIAPDTSPRGLGYPGEDDAYDFGTGAGFYVDATETPWRDGYRMYSYITRELPALINASFPVDPARVGIFGHSMGGHGALT
IALKNPGAYRSVSAFAPIVSPMRCPWGEKALTGYLGVDRANWRAYDATALIEDRGWAGPAILVDQGTADPFLERELKPEL
LREACAAKGVKLDLRMQEGYDHSYFFIATFVEDHLRHHARHL

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=278, Percent_Identity=60.0719424460432, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=54.4802867383513, Blast_Score=298, Evalue=2e-82,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=46.9314079422383, Blast_Score=278, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17510185, Length=278, Percent_Identity=48.9208633093525, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=40.8783783783784, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=53.7102473498233, Blast_Score=312, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24648347, Length=278, Percent_Identity=53.9568345323741, Blast_Score=308, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30808; Mature: 30677

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSATVLETVSTQKCFGGMQGVYRHEAKETGCTMRFAVFLPPQAAAGTVPALYYLAGLTC
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHCCEE
TEENFTVKAGAQRVAAELGIALIAPDTSPRGLGYPGEDDAYDFGTGAGFYVDATETPWRD
CCCCEEEEHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
GYRMYSYITRELPALINASFPVDPARVGIFGHSMGGHGALTIALKNPGAYRSVSAFAPIV
CHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHH
SPMRCPWGEKALTGYLGVDRANWRAYDATALIEDRGWAGPAILVDQGTADPFLERELKPE
CCCCCCCCCHHHHHCCCCCCCCCEEECEEEEEECCCCCCCEEEEECCCCCHHHHHCCCHH
LLREACAAKGVKLDLRMQEGYDHSYFFIATFVEDHLRHHARHL
HHHHHHHHCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSATVLETVSTQKCFGGMQGVYRHEAKETGCTMRFAVFLPPQAAAGTVPALYYLAGLTC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHCCEE
TEENFTVKAGAQRVAAELGIALIAPDTSPRGLGYPGEDDAYDFGTGAGFYVDATETPWRD
CCCCEEEEHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
GYRMYSYITRELPALINASFPVDPARVGIFGHSMGGHGALTIALKNPGAYRSVSAFAPIV
CHHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHH
SPMRCPWGEKALTGYLGVDRANWRAYDATALIEDRGWAGPAILVDQGTADPFLERELKPE
CCCCCCCCCHHHHHCCCCCCCCCEEECEEEEEECCCCCCCEEEEECCCCCHHHHHCCCHH
LLREACAAKGVKLDLRMQEGYDHSYFFIATFVEDHLRHHARHL
HHHHHHHHCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]