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The map label for this gene is pepA

Identifier: 148242908

GI number: 148242908

Start: 1572544

End: 1574049

Strand: Direct

Name: pepA

Synonym: SynRCC307_1809

Alternate gene names: 148242908

Gene position: 1572544-1574049 (Clockwise)

Preceding gene: 148242907

Following gene: 148242909

Centisome position: 70.68

GC content: 64.14

Gene sequence:

>1506_bases
ATGAATTTCCGCTGCAGTTCCGCTCCCCTGGCGGAGCTCGGCTGTGATGGTGTTGCCCTGGGCCTATTCAGCAGCAGCTG
GCAGCAACAACTGGCCGCTCTGCTGCCAGCGATGGCCGCCCAATTGCAGCCGCTCCTGGAGCAGCGCGAGTTCAAAGCCA
AAGGTGGTGAGAAGCACAGCTTCAGCTTTCCTGGCCAGCAGCCATCGCTGGTGATCATTAGCGGCTTGGGCGAGCCGGAT
AGCTTTGACGGCCTGGCGCTGCGCAAAGCCGCCGCCAGCCTGGCCCTGGCCAGCCGCGGCTCCAACCTCAAGGCGCTAGC
GCTGGGTCTGCCGATCGAAGCCTTTGCCCCCGATCAAGCCCTCACGGCCTTGATGCAGGGCTGCCGGCTGGCCCTCTACA
AAGACGAGCGCTTCCGTAGTGAAAACAAGCCCAGCCTCGATCCCGGCGAGATTGTGTTGCAGGGCCTAGCCAGCGAGCTG
GATCAACAACTGGCGCAGCAGGAAGCCATTTGCCAAGGCGTGATGCTGGCCCGCGAGTTGGTGGCGGCCCCGCCCAATGT
GGTGAATGCCCTGAGCCTGGAATCCACCGCCCGCTCCATCGCTGATCAATTTGGCTGCGAGCTCACCGTTCTCGATGAAG
CGGCTTGCCGCGAGCGCGGCATGGGGGCCTATTTGGCCGTGGCCCAAGGGGCCAGCATCCCGCCCCGGTTCCTGCACCTG
GTGATTCGCCCGCAAGGACCTGTGAAACGCAAGCTGGCCTTGGTGGGCAAAGGCCTCACCTTTGATTCCGGCGGCTACAA
CCTCAAAGTGGGCGGCAGCCAGATCGAATTGATGAAGTTCGATATGGGCGGCTGCGGCGCGGTGCTTGGAGCGGCCCGGA
CCCTGGCTGAACTCAAGCTGGAGGGGCTGGAGATCCATGTGATCAGCGCAGCCACCGAAAACATGGTCAGCGCCGAGGCG
ATCTACCCCGGCGCCATTGTGACGGCCTCCAATGGCAAAACCATCGAGATCAACAACACCGACGCCGAAGGGCGCCTCAC
CCTGGCCGATGCCCTGGTCTATGCCTGCGGCCTGGAGCCAGATGCCATCGTTGATTTGGCCACCCTCACCGGGGCCTGCG
TGATTGCCCTGGGCGATGAAATCGCTGGCTATTGGAGCCCCGACGATGGCCTGGCCCAGCAGCTCAACGATGCCGCCCAT
CGCGCTGGCGAAGGGCTCTGGCGCATGCCGCTGCAGAGCTCCTACAAAGACGGGCTCAAGAGCGGACTCGCCGACATGAA
AAACACCGGGCCCCGTCCCGGTGGTTCGATCACCGCAGCCCTGTTCCTCAAGGAGTTCGTCAAGCCTGAGATCCCCTGGG
CCCACATCGACATCGCCGGGCCGGTGTGGAGCGACAAGGGCCGCAGCACCGATCCCTCTGGCGCCACCGGCTACGGCGTC
CGCACCCTGGTGGAGTGGTGCCAGGCAGTTGCTGCTGATGCGAAGGAAGGGTTAAGCCAGGGGTGA

Upstream 100 bases:

>100_bases
CAATAAGGAGTGCCGCCAGCGCTGGCAGACACCGTTCCAGAGCGAGCTCCACTAATCAGGCAGCACCGGTACGATCGCGC
GACCACCCCGTTGCGCCGTC

Downstream 100 bases:

>100_bases
TCCACTCCCGGTGTTTATAAGTTGTTCCAGCCCACCAGCTCAGATCACAGCGCCTTCTGGTTCGAGGACACCAGTCCGAG
CCAGTGGGATGGCGATGTCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNFRCSSAPLAELGCDGVALGLFSSSWQQQLAALLPAMAAQLQPLLEQREFKAKGGEKHSFSFPGQQPSLVIISGLGEPD
SFDGLALRKAAASLALASRGSNLKALALGLPIEAFAPDQALTALMQGCRLALYKDERFRSENKPSLDPGEIVLQGLASEL
DQQLAQQEAICQGVMLARELVAAPPNVVNALSLESTARSIADQFGCELTVLDEAACRERGMGAYLAVAQGASIPPRFLHL
VIRPQGPVKRKLALVGKGLTFDSGGYNLKVGGSQIELMKFDMGGCGAVLGAARTLAELKLEGLEIHVISAATENMVSAEA
IYPGAIVTASNGKTIEINNTDAEGRLTLADALVYACGLEPDAIVDLATLTGACVIALGDEIAGYWSPDDGLAQQLNDAAH
RAGEGLWRMPLQSSYKDGLKSGLADMKNTGPRPGGSITAALFLKEFVKPEIPWAHIDIAGPVWSDKGRSTDPSGATGYGV
RTLVEWCQAVAADAKEGLSQG

Sequences:

>Translated_501_residues
MNFRCSSAPLAELGCDGVALGLFSSSWQQQLAALLPAMAAQLQPLLEQREFKAKGGEKHSFSFPGQQPSLVIISGLGEPD
SFDGLALRKAAASLALASRGSNLKALALGLPIEAFAPDQALTALMQGCRLALYKDERFRSENKPSLDPGEIVLQGLASEL
DQQLAQQEAICQGVMLARELVAAPPNVVNALSLESTARSIADQFGCELTVLDEAACRERGMGAYLAVAQGASIPPRFLHL
VIRPQGPVKRKLALVGKGLTFDSGGYNLKVGGSQIELMKFDMGGCGAVLGAARTLAELKLEGLEIHVISAATENMVSAEA
IYPGAIVTASNGKTIEINNTDAEGRLTLADALVYACGLEPDAIVDLATLTGACVIALGDEIAGYWSPDDGLAQQLNDAAH
RAGEGLWRMPLQSSYKDGLKSGLADMKNTGPRPGGSITAALFLKEFVKPEIPWAHIDIAGPVWSDKGRSTDPSGATGYGV
RTLVEWCQAVAADAKEGLSQG
>Mature_501_residues
MNFRCSSAPLAELGCDGVALGLFSSSWQQQLAALLPAMAAQLQPLLEQREFKAKGGEKHSFSFPGQQPSLVIISGLGEPD
SFDGLALRKAAASLALASRGSNLKALALGLPIEAFAPDQALTALMQGCRLALYKDERFRSENKPSLDPGEIVLQGLASEL
DQQLAQQEAICQGVMLARELVAAPPNVVNALSLESTARSIADQFGCELTVLDEAACRERGMGAYLAVAQGASIPPRFLHL
VIRPQGPVKRKLALVGKGLTFDSGGYNLKVGGSQIELMKFDMGGCGAVLGAARTLAELKLEGLEIHVISAATENMVSAEA
IYPGAIVTASNGKTIEINNTDAEGRLTLADALVYACGLEPDAIVDLATLTGACVIALGDEIAGYWSPDDGLAQQLNDAAH
RAGEGLWRMPLQSSYKDGLKSGLADMKNTGPRPGGSITAALFLKEFVKPEIPWAHIDIAGPVWSDKGRSTDPSGATGYGV
RTLVEWCQAVAADAKEGLSQG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=498, Percent_Identity=32.9317269076305, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI47155554, Length=321, Percent_Identity=34.2679127725857, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1790710, Length=310, Percent_Identity=45.4838709677419, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082123, Length=281, Percent_Identity=40.5693950177936, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17556903, Length=334, Percent_Identity=32.0359281437126, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17565172, Length=376, Percent_Identity=26.8617021276596, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24661038, Length=330, Percent_Identity=32.7272727272727, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357381, Length=330, Percent_Identity=30, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI221379063, Length=330, Percent_Identity=30, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI221379062, Length=330, Percent_Identity=30, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI20129969, Length=322, Percent_Identity=30.4347826086957, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077148, Length=287, Percent_Identity=30.6620209059233, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20130057, Length=287, Percent_Identity=30.6620209059233, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355645, Length=287, Percent_Identity=29.9651567944251, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662223, Length=287, Percent_Identity=29.9651567944251, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=432, Percent_Identity=29.1666666666667, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662227, Length=245, Percent_Identity=30.2040816326531, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646701, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=345, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_SYNR3 (A5GV03)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001228065.1
- ProteinModelPortal:   A5GV03
- SMR:   A5GV03
- STRING:   A5GV03
- MEROPS:   M17.002
- GeneID:   5156831
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_1809
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   CKPTRII
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52553; Mature: 52553

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 269-269 ACT_SITE 345-345

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFRCSSAPLAELGCDGVALGLFSSSWQQQLAALLPAMAAQLQPLLEQREFKAKGGEKHS
CCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FSFPGQQPSLVIISGLGEPDSFDGLALRKAAASLALASRGSNLKALALGLPIEAFAPDQA
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCHHH
LTALMQGCRLALYKDERFRSENKPSLDPGEIVLQGLASELDQQLAQQEAICQGVMLAREL
HHHHHHCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAPPNVVNALSLESTARSIADQFGCELTVLDEAACRERGMGAYLAVAQGASIPPRFLHL
HHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCEEEEEECCCCCCHHHEEE
VIRPQGPVKRKLALVGKGLTFDSGGYNLKVGGSQIELMKFDMGGCGAVLGAARTLAELKL
EECCCCCHHHHHHHHCCCCEECCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHH
EGLEIHVISAATENMVSAEAIYPGAIVTASNGKTIEINNTDAEGRLTLADALVYACGLEP
CCEEEEEEECCHHHHHHHHEECCCEEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCC
DAIVDLATLTGACVIALGDEIAGYWSPDDGLAQQLNDAAHRAGEGLWRMPLQSSYKDGLK
HHHHHHHHHHCEEEEEECCHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
SGLADMKNTGPRPGGSITAALFLKEFVKPEIPWAHIDIAGPVWSDKGRSTDPSGATGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHH
RTLVEWCQAVAADAKEGLSQG
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNFRCSSAPLAELGCDGVALGLFSSSWQQQLAALLPAMAAQLQPLLEQREFKAKGGEKHS
CCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FSFPGQQPSLVIISGLGEPDSFDGLALRKAAASLALASRGSNLKALALGLPIEAFAPDQA
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCHHH
LTALMQGCRLALYKDERFRSENKPSLDPGEIVLQGLASELDQQLAQQEAICQGVMLAREL
HHHHHHCCEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAPPNVVNALSLESTARSIADQFGCELTVLDEAACRERGMGAYLAVAQGASIPPRFLHL
HHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHCCCCEEEEEECCCCCCHHHEEE
VIRPQGPVKRKLALVGKGLTFDSGGYNLKVGGSQIELMKFDMGGCGAVLGAARTLAELKL
EECCCCCHHHHHHHHCCCCEECCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHH
EGLEIHVISAATENMVSAEAIYPGAIVTASNGKTIEINNTDAEGRLTLADALVYACGLEP
CCEEEEEEECCHHHHHHHHEECCCEEEECCCCCEEEEECCCCCCEEEHHHHHHHHCCCCC
DAIVDLATLTGACVIALGDEIAGYWSPDDGLAQQLNDAAHRAGEGLWRMPLQSSYKDGLK
HHHHHHHHHHCEEEEEECCHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHH
SGLADMKNTGPRPGGSITAALFLKEFVKPEIPWAHIDIAGPVWSDKGRSTDPSGATGYGV
HHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHH
RTLVEWCQAVAADAKEGLSQG
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA