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The map label for this gene is lexA [H]

Identifier: 148242855

GI number: 148242855

Start: 1537534

End: 1538148

Strand: Direct

Name: lexA [H]

Synonym: SynRCC307_1756

Alternate gene names: 148242855

Gene position: 1537534-1538148 (Clockwise)

Preceding gene: 148242854

Following gene: 148242856

Centisome position: 69.11

GC content: 66.18

Gene sequence:

>615_bases
ATGCCCCTTGAGGCCCTGACCGCCGCCCAGCAAGAGCTCTACGACTGGCTGGCTGAATTCATCGCCGACAATCGCCACAG
CCCCTCCATCCGCCAGATGATGCAGGGCATGGGTTTGCGCTCCCCAGCGCCGATCCAGAGCCGCCTGCGCCACCTGCAGC
AAAAGGGCTGGATCACCTGGCAAGAGGGCCAGGCCCGCACCCTGCAGTTGTTGGGTGACGCCGCCGACTCCCTCGGCATC
CCCGTGCTCGGCGCCGTCGCCGCTGGCGGCCTGATCGAAACCTTTGACGACGTGCAAGAGCACCTCGACATCGCCCCCAC
CCTGGAGCGGCGCGGGTTGTTTGCGCTCACCGTCAACGGCGACAGCATGAAAGATGCCCACATCGCCGATGGCGATGTAG
TGCTGATGGAGCCTGTGCGTGATCCTTCTCGCCTCAAGCCCGGCACCATCGTCAGCGCCCTGGTGGCCGGCAGCGGCACC
ACCTTGAAGCACTTCCACTTGCGCGGCGGCGAAGTGAGCCTGGAAGCCGCCAATCCCAACTACGAGCCGATCACCCTGCC
CGCCGAAGAGGTCACCGTGCAGGGCCAACTCGTGGCCGTCTGGCGCCAGGTCTGA

Upstream 100 bases:

>100_bases
CCCAACAGGCTCTGTTGGCAACACTTTTGGGCGCCGAGGGGTAGACAAACCGGCTTTTCAGTGGCACAAATGTATTAGTG
CTGTTGCCCACGCCCCTGCC

Downstream 100 bases:

>100_bases
GGTGTAAGCTCTCACACGTGCTGAGCGCTGCTCGCACACATGGGGCCATAGCTCAGCTGGTAGAGCACCTGCATGGCATG
CAGGGGGTCAGGAGTTCGAG

Product: SOS-response transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MPLEALTAAQQELYDWLAEFIADNRHSPSIRQMMQGMGLRSPAPIQSRLRHLQQKGWITWQEGQARTLQLLGDAADSLGI
PVLGAVAAGGLIETFDDVQEHLDIAPTLERRGLFALTVNGDSMKDAHIADGDVVLMEPVRDPSRLKPGTIVSALVAGSGT
TLKHFHLRGGEVSLEAANPNYEPITLPAEEVTVQGQLVAVWRQV

Sequences:

>Translated_204_residues
MPLEALTAAQQELYDWLAEFIADNRHSPSIRQMMQGMGLRSPAPIQSRLRHLQQKGWITWQEGQARTLQLLGDAADSLGI
PVLGAVAAGGLIETFDDVQEHLDIAPTLERRGLFALTVNGDSMKDAHIADGDVVLMEPVRDPSRLKPGTIVSALVAGSGT
TLKHFHLRGGEVSLEAANPNYEPITLPAEEVTVQGQLVAVWRQV
>Mature_203_residues
PLEALTAAQQELYDWLAEFIADNRHSPSIRQMMQGMGLRSPAPIQSRLRHLQQKGWITWQEGQARTLQLLGDAADSLGIP
VLGAVAAGGLIETFDDVQEHLDIAPTLERRGLFALTVNGDSMKDAHIADGDVVLMEPVRDPSRLKPGTIVSALVAGSGTT
LKHFHLRGGEVSLEAANPNYEPITLPAEEVTVQGQLVAVWRQV

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=203, Percent_Identity=31.5270935960591, Blast_Score=92, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 22172; Mature: 22040

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLEALTAAQQELYDWLAEFIADNRHSPSIRQMMQGMGLRSPAPIQSRLRHLQQKGWITW
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEE
QEGQARTLQLLGDAADSLGIPVLGAVAAGGLIETFDDVQEHLDIAPTLERRGLFALTVNG
ECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCEEEEEECC
DSMKDAHIADGDVVLMEPVRDPSRLKPGTIVSALVAGSGTTLKHFHLRGGEVSLEAANPN
CCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCC
YEPITLPAEEVTVQGQLVAVWRQV
CCEEEECHHHEEECCCEEEEECCC
>Mature Secondary Structure 
PLEALTAAQQELYDWLAEFIADNRHSPSIRQMMQGMGLRSPAPIQSRLRHLQQKGWITW
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEE
QEGQARTLQLLGDAADSLGIPVLGAVAAGGLIETFDDVQEHLDIAPTLERRGLFALTVNG
ECCCHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCEEEEEECC
DSMKDAHIADGDVVLMEPVRDPSRLKPGTIVSALVAGSGTTLKHFHLRGGEVSLEAANPN
CCCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEEECCCC
YEPITLPAEEVTVQGQLVAVWRQV
CCEEEECHHHEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA