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The map label for this gene is hisZ

Identifier: 148242468

GI number: 148242468

Start: 1215086

End: 1216267

Strand: Direct

Name: hisZ

Synonym: SynRCC307_1369

Alternate gene names: 148242468

Gene position: 1215086-1216267 (Clockwise)

Preceding gene: 148242467

Following gene: 148242469

Centisome position: 54.61

GC content: 65.14

Gene sequence:

>1182_bases
ATGGCCCTTCAGCCCGCCAGTGGAGCCCGCGACCTCCTGCCCCGCGACGTGGGGGTTAACCGCTGGATTGCCGAGCAACT
GGCTGCCGTCTACCAGCGCTGGGGCTACGAAGAGGTCACCCCGCCCAGCCTGGAGCGGATCGACACCCTCGAGGCCGGCG
GTGCAATCCAATCGCACCAGGTGGTGCAAGTGGTGGCCGATGAGGCTCTCGGCCTGCGCCCGGAAATGACCGCCAGCATC
GCCCGGGCCGCTTGTACGCGCCTGGCAGCCATGCAGCGCCCCCTACGGCTGCACTACCGCGGTTCCACCTTCCAAGCCCA
ACGAGCGGAAGACCAAGGTCTGCGCATTGTCGAAGACCTGCAGAGCGGCGTGGAACTGATGGGCGCCAAGGGGCTTGCCG
GTGATGCCGAACTGCTGCGTCTGCTGCTCGATGCCGGCTCCCATCTGCCGCTTAGCGCAGAGCATCAGCCCACCCTGCTG
ATCGGCCATCAACGGTTGCTGTCGGTGCTGCTCGAAGCTGTGGAGCCATCGCTGCGCAGCACGGTGCGCCGCCACGTCTG
CGGACTCAACCGCGTGGCCCTCTCCCAGCTAGAGCTGCCAGGGCAGCAACGCTTGCAACTGCTGCAATTGCTGCAGCTGC
GCGGGGAACCCGCAGCGGTACTCAACGGACTTGAAGCCCTGCTGGGAGCAACGGATCTGCTCGCCGAGCTGAAACAGCTG
ATCAGCATCATTGAGGAGCAGGCCAGCCGCGCCGGCATTCGCCTGCAGCTAGATCCCACCTTCCATCCCGACTTCGAGCT
CTATGACGGGGTGATGGTGAAGTTGGTCTGCCAGGGGCTTGATGCGCCGGTGGCCATCGCCAGTGGCGGCCGCTATGACG
CTTTGGTCCAGCGCTTCAGCCCAGTGGGGGCGGTAGCCAGCGGTGTGGGATTCAGCTTTGCCGTTGAGGCGGTGCGTCAA
CTGTTGGAGCAAGCCGATCAACTACCCCCGCGGCTAGACGGCCAACTGGTCTTGGTGGCCTACAGCCAGTCCAGCCAATT
GCATCCGGCCTTGAACCTGCTGGAGCAGCTGCATCAAAGTGGCCAACCCGCTGAGCTCTGGCCCGAGCCCTGCGCCAACC
AAGACGAGGCCCAAGGCATCGCCACACAACGCGGCGTTCAAACGGTTCGCTGGGTGGGTTGA

Upstream 100 bases:

>100_bases
TGTTGCAGGGCCTATCCGAATGCCAACCGCTGCCGCCTGCGACCTACAACGCTGAGATCCCCGCTGGTCCATAGGATTCG
GCGGCAACCGTGCCGATCGG

Downstream 100 bases:

>100_bases
ATCCTTAAGATCAGCGGGTCTGCAAGCCCCTCTTGGCACACACCATCGTCACCAACGTCTGCGAAGGGATCGCCGACTGC
GTCGATGCCTGCCCTGTGGC

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MALQPASGARDLLPRDVGVNRWIAEQLAAVYQRWGYEEVTPPSLERIDTLEAGGAIQSHQVVQVVADEALGLRPEMTASI
ARAACTRLAAMQRPLRLHYRGSTFQAQRAEDQGLRIVEDLQSGVELMGAKGLAGDAELLRLLLDAGSHLPLSAEHQPTLL
IGHQRLLSVLLEAVEPSLRSTVRRHVCGLNRVALSQLELPGQQRLQLLQLLQLRGEPAAVLNGLEALLGATDLLAELKQL
ISIIEEQASRAGIRLQLDPTFHPDFELYDGVMVKLVCQGLDAPVAIASGGRYDALVQRFSPVGAVASGVGFSFAVEAVRQ
LLEQADQLPPRLDGQLVLVAYSQSSQLHPALNLLEQLHQSGQPAELWPEPCANQDEAQGIATQRGVQTVRWVG

Sequences:

>Translated_393_residues
MALQPASGARDLLPRDVGVNRWIAEQLAAVYQRWGYEEVTPPSLERIDTLEAGGAIQSHQVVQVVADEALGLRPEMTASI
ARAACTRLAAMQRPLRLHYRGSTFQAQRAEDQGLRIVEDLQSGVELMGAKGLAGDAELLRLLLDAGSHLPLSAEHQPTLL
IGHQRLLSVLLEAVEPSLRSTVRRHVCGLNRVALSQLELPGQQRLQLLQLLQLRGEPAAVLNGLEALLGATDLLAELKQL
ISIIEEQASRAGIRLQLDPTFHPDFELYDGVMVKLVCQGLDAPVAIASGGRYDALVQRFSPVGAVASGVGFSFAVEAVRQ
LLEQADQLPPRLDGQLVLVAYSQSSQLHPALNLLEQLHQSGQPAELWPEPCANQDEAQGIATQRGVQTVRWVG
>Mature_392_residues
ALQPASGARDLLPRDVGVNRWIAEQLAAVYQRWGYEEVTPPSLERIDTLEAGGAIQSHQVVQVVADEALGLRPEMTASIA
RAACTRLAAMQRPLRLHYRGSTFQAQRAEDQGLRIVEDLQSGVELMGAKGLAGDAELLRLLLDAGSHLPLSAEHQPTLLI
GHQRLLSVLLEAVEPSLRSTVRRHVCGLNRVALSQLELPGQQRLQLLQLLQLRGEPAAVLNGLEALLGATDLLAELKQLI
SIIEEQASRAGIRLQLDPTFHPDFELYDGVMVKLVCQGLDAPVAIASGGRYDALVQRFSPVGAVASGVGFSFAVEAVRQL
LEQADQLPPRLDGQLVLVAYSQSSQLHPALNLLEQLHQSGQPAELWPEPCANQDEAQGIATQRGVQTVRWVG

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily

Homologues:

Organism=Homo sapiens, GI6996014, Length=408, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISZ_SYNR3 (A5GTR3)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227625.1
- ProteinModelPortal:   A5GTR3
- SMR:   A5GTR3
- STRING:   A5GTR3
- GeneID:   5156780
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_1369
- eggNOG:   COG3705
- HOGENOM:   HBG616575
- OMA:   YREHVKS
- ProtClustDB:   PRK12292
- GO:   GO:0005737
- HAMAP:   MF_00125
- InterPro:   IPR006195
- InterPro:   IPR004516
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 42616; Mature: 42485

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQPASGARDLLPRDVGVNRWIAEQLAAVYQRWGYEEVTPPSLERIDTLEAGGAIQSHQ
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHH
VVQVVADEALGLRPEMTASIARAACTRLAAMQRPLRLHYRGSTFQAQRAEDQGLRIVEDL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCHHCCHHHHHHH
QSGVELMGAKGLAGDAELLRLLLDAGSHLPLSAEHQPTLLIGHQRLLSVLLEAVEPSLRS
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCHHHHH
TVRRHVCGLNRVALSQLELPGQQRLQLLQLLQLRGEPAAVLNGLEALLGATDLLAELKQL
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISIIEEQASRAGIRLQLDPTFHPDFELYDGVMVKLVCQGLDAPVAIASGGRYDALVQRFS
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHC
PVGAVASGVGFSFAVEAVRQLLEQADQLPPRLDGQLVLVAYSQSSQLHPALNLLEQLHQS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
GQPAELWPEPCANQDEAQGIATQRGVQTVRWVG
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
ALQPASGARDLLPRDVGVNRWIAEQLAAVYQRWGYEEVTPPSLERIDTLEAGGAIQSHQ
CCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHH
VVQVVADEALGLRPEMTASIARAACTRLAAMQRPLRLHYRGSTFQAQRAEDQGLRIVEDL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCHHCCHHHHHHH
QSGVELMGAKGLAGDAELLRLLLDAGSHLPLSAEHQPTLLIGHQRLLSVLLEAVEPSLRS
HHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHHHHHCHHHHH
TVRRHVCGLNRVALSQLELPGQQRLQLLQLLQLRGEPAAVLNGLEALLGATDLLAELKQL
HHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISIIEEQASRAGIRLQLDPTFHPDFELYDGVMVKLVCQGLDAPVAIASGGRYDALVQRFS
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHC
PVGAVASGVGFSFAVEAVRQLLEQADQLPPRLDGQLVLVAYSQSSQLHPALNLLEQLHQS
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
GQPAELWPEPCANQDEAQGIATQRGVQTVRWVG
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA