Click here to switch to the map view.

The map label for this gene is hemC

Identifier: 148241995

GI number: 148241995

Start: 813410

End: 814363

Strand: Direct

Name: hemC

Synonym: SynRCC307_0896

Alternate gene names: 148241995

Gene position: 813410-814363 (Clockwise)

Preceding gene: 148241993

Following gene: 148241996

Centisome position: 36.56

GC content: 60.17

Gene sequence:

>954_bases
ATGACGGCCTCTTCTTTGCGTATTGCCTCTCGCCGCAGCCAATTGGCGATGGTTCAGACCGAGTGGGTGCGTGATGAGCT
CGCCAACGCTCACCCCGGTCTGGAGATCAGCATCGAGGCGATGGCCACCCAGGGCGACAAGATTCTCGATGTGGCCCTGG
CCAAGATTGGCGACAAGGGACTGTTCACCAAAGAGCTAGAAGCTCAAATGCTGGTGAACCGGGCTGATATCGCTGTTCAT
AGCCTCAAAGATCTGCCCACCAACCTTCCAGAAGGGCTGATGCTCGGCTGCATCACCGAGCGGGAAGATCCTGCCGATGC
CCTGGTGATGCATGCCAAAAACAAAGACCTCACCCTGGCCACCCTGCCTGAGGGTGCCGTGGTGGGCACCAGCTCCCTGC
GCCGTTTGGCCCAGCTCAGGTACCACTACCCGCACCTCACCTTCAAAGATGTGCGCGGCAATGTGATCACTCGCCTCGAG
AAGCTGGATTCCGGTCAGTTCGATTGCTTGATCTTGGCGGCAGCTGGTTTGGGCCGCCTTGGCCTGGGTGATCGCATCCA
TGAGCTGATTGATCCTTCGATCTCCCTGCATGCCGTGGGCCAAGGCGCCTTGGGCATCGAATGCCGCGATGGTGATGCGG
CTGTTCTCGAGCAAATCAAGGTGCTGGAGCACCGCCCCACCTCCCTGCGTTGTTTGGCCGAACGCGCGTTCCTGCGCACC
TTGGAAGGTGGCTGTCAGGTGCCGATCGGCGTGAACACCCGTTTTGAAGGAGATGAGCTGGTGCTCACCGGCATGGTGGC
CAGCCTTGATGGCAAACAACTCATCCGCGACGAGCTCCGCGCGCCTCAAGATCAGGCTGAGGACCTGGGCAATCGCTTAG
CTGAGTTGCTGCGCAGCCAAGGTGCTGGCGAGATCCTCGCCAAGATCTTTGCTGAAGCCCGCCCTGAGGCCTGA

Upstream 100 bases:

>100_bases
AAGCGTATCGACGCTGGAGCTGTTTTGTGCCTGGATCCAAGGGCCTGCTGCGTAGGGTGGAGAGCGCTCGAGGGCTGCTG
CAGCGCCCTGTTCCCCCTGC

Downstream 100 bases:

>100_bases
TGGCATGACAAGCGGTCCTGCAGCCGAGCAGCTCAGGAGCTACTTGCATCAAACCCGTCTGCTGAATTCGATCAGCAGCG
CGCTGTATTTCGATCAAAAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTASSLRIASRRSQLAMVQTEWVRDELANAHPGLEISIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVNRADIAVH
SLKDLPTNLPEGLMLGCITEREDPADALVMHAKNKDLTLATLPEGAVVGTSSLRRLAQLRYHYPHLTFKDVRGNVITRLE
KLDSGQFDCLILAAAGLGRLGLGDRIHELIDPSISLHAVGQGALGIECRDGDAAVLEQIKVLEHRPTSLRCLAERAFLRT
LEGGCQVPIGVNTRFEGDELVLTGMVASLDGKQLIRDELRAPQDQAEDLGNRLAELLRSQGAGEILAKIFAEARPEA

Sequences:

>Translated_317_residues
MTASSLRIASRRSQLAMVQTEWVRDELANAHPGLEISIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVNRADIAVH
SLKDLPTNLPEGLMLGCITEREDPADALVMHAKNKDLTLATLPEGAVVGTSSLRRLAQLRYHYPHLTFKDVRGNVITRLE
KLDSGQFDCLILAAAGLGRLGLGDRIHELIDPSISLHAVGQGALGIECRDGDAAVLEQIKVLEHRPTSLRCLAERAFLRT
LEGGCQVPIGVNTRFEGDELVLTGMVASLDGKQLIRDELRAPQDQAEDLGNRLAELLRSQGAGEILAKIFAEARPEA
>Mature_316_residues
TASSLRIASRRSQLAMVQTEWVRDELANAHPGLEISIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVNRADIAVHS
LKDLPTNLPEGLMLGCITEREDPADALVMHAKNKDLTLATLPEGAVVGTSSLRRLAQLRYHYPHLTFKDVRGNVITRLEK
LDSGQFDCLILAAAGLGRLGLGDRIHELIDPSISLHAVGQGALGIECRDGDAAVLEQIKVLEHRPTSLRCLAERAFLRTL
EGGCQVPIGVNTRFEGDELVLTGMVASLDGKQLIRDELRAPQDQAEDLGNRLAELLRSQGAGEILAKIFAEARPEA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=48.9425981873112, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=48.9425981873112, Blast_Score=293, Evalue=1e-79,
Organism=Escherichia coli, GI48994974, Length=311, Percent_Identity=53.6977491961415, Blast_Score=295, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=321, Percent_Identity=42.6791277258567, Blast_Score=240, Evalue=2e-64,
Organism=Drosophila melanogaster, GI20130425, Length=318, Percent_Identity=44.9685534591195, Blast_Score=254, Evalue=6e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_SYNR3 (A5GSE0)

Other databases:

- EMBL:   CT978603
- RefSeq:   YP_001227152.1
- ProteinModelPortal:   A5GSE0
- SMR:   A5GSE0
- STRING:   A5GSE0
- GeneID:   5158755
- GenomeReviews:   CT978603_GR
- KEGG:   syr:SynRCC307_0896
- eggNOG:   COG0181
- HOGENOM:   HBG624842
- OMA:   SLHAVGQ
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 34398; Mature: 34267

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASSLRIASRRSQLAMVQTEWVRDELANAHPGLEISIEAMATQGDKILDVALAKIGDKG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVNRADIAVHSLKDLPTNLPEGLMLGCITEREDPADALVMHAKNKDLTLA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHEEEEECCCCEEEE
TLPEGAVVGTSSLRRLAQLRYHYPHLTFKDVRGNVITRLEKLDSGQFDCLILAAAGLGRL
ECCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCC
GLGDRIHELIDPSISLHAVGQGALGIECRDGDAAVLEQIKVLEHRPTSLRCLAERAFLRT
CCHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNTRFEGDELVLTGMVASLDGKQLIRDELRAPQDQAEDLGNRLAELLRSQ
HCCCCEEEECCCCCCCCCCEEEEEHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GAGEILAKIFAEARPEA
CHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TASSLRIASRRSQLAMVQTEWVRDELANAHPGLEISIEAMATQGDKILDVALAKIGDKG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
LFTKELEAQMLVNRADIAVHSLKDLPTNLPEGLMLGCITEREDPADALVMHAKNKDLTLA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHEEEEECCCCEEEE
TLPEGAVVGTSSLRRLAQLRYHYPHLTFKDVRGNVITRLEKLDSGQFDCLILAAAGLGRL
ECCCCCEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCC
GLGDRIHELIDPSISLHAVGQGALGIECRDGDAAVLEQIKVLEHRPTSLRCLAERAFLRT
CCHHHHHHHHCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LEGGCQVPIGVNTRFEGDELVLTGMVASLDGKQLIRDELRAPQDQAEDLGNRLAELLRSQ
HCCCCEEEECCCCCCCCCCEEEEEHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
GAGEILAKIFAEARPEA
CHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA