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The map label for this gene is ndhD [H]

Identifier: 148241927

GI number: 148241927

Start: 753544

End: 755064

Strand: Direct

Name: ndhD [H]

Synonym: SynRCC307_0828

Alternate gene names: 148241927

Gene position: 753544-755064 (Clockwise)

Preceding gene: 148241926

Following gene: 148241928

Centisome position: 33.87

GC content: 59.89

Gene sequence:

>1521_bases
TTGGTGGAGGGCTGCCTGATGCTCACGGCTCTGTTATTGATCCCCTTCCTTGGGGGCCTGCTGCTGCTGCTTCTGCCCTC
CAGCGTGGCTCCAGTTCGCATGCGCAGCGTGGCGATCGTGTTCTTGTCGCTGCAGCTGCTGCTTTCGGTGGCGCTGTTGA
TTCCGTTTGACCCGTCGGTAGGAACGCCCCAGCTGGTGGAGTTCACCCCCTGGGTCAGCCGCATTGGTTTGGATTACCGC
CTGGCGGTGGATGGCCTGTCGCTGCCGTTGATCCTGATCAACGCCGCGCTGACGTTGGTTTCGGCGGTTTGCACCCGCGA
TTTTGACCAGCGTCCGCGCATCTACTTCTCAATGCTGCTGCTGATTAGCGGCGCAGTGAACGGAGCCTTCTTGGCCGACA
ACCTGCTGCTGTTCGTGATCTTTTACGAGCTGGAGCTGATCCCTCTATGGCTGCTGATCGCGGTTTGGGGCGGTGCCAAT
CGGGGCTATGCCTCCACCAAGTTTTTGATCTTCACCGCGGTTTCAGGCTTTTTGATCCTGGCGGCCTTCTTCGGTTTGGC
CCTGGTCAGCGGCAGCGTCAACTTCAACATCACCCCAGCGCTCACTGAAAACTTGCCGGTGGCCACGCAGCTGGTGCTGC
TGGTCACGCTGCTGATTGGCTTTGGTATCAAGATTCCGCTGGTGCCCTTCCATGTCTGGCTACCGGATGCCCACACCCAG
GCCTCAACGCCGGTGTCAGTGATGTTGGCCGGTGTCTTGCTCAAGCTCGGCACCTATGGCTTGCTCCGCTTTGGCCTTGG
CCTGTTCCAAGAGGTTTGGCCCTTGGTGGCCCCCTGGCTGGCGATTTGGGCGGCGATTTCGGTTCTGTATGGATCGCTGG
CGGCCATTGCCCAGAGCGACATGAAGCGGATGGTGGCGTTTAGCTCGGTGGGTCACATGGGCTACGTGTTGCTTGCCGCT
GCGGCAGCCACGCCCACCGCCTTGTTGGGGGCTGTGTTCCAGATGGTGAGCCACGGCGTGATCTCAGCCCTGCTGTTCCT
TTTGGTGGGCACCGTTTATCGCAAAACCGGTACGCGTGATCTCAGTGTGATCCGCGGGTTGTTAAATCCTGAGCGCGGTT
TACCTCTCACCGGCACCTTGATGATTCTTGGGGTGATGGCCAGTGCCGGACTGCCTGGCATGGCCGGATTCATCTCTGAA
TTCCTGGTGTTCCAAGGCAGTATCCAAACCTTCCCGTTGGCCACCTTGCTCAGCATGGTGGGGTCTGGCCTGACGGCGGT
GTATTTCCTCCTGCTGGTGAACCGCGCGTTCTTTGGTCGTTTGGCGGTGACTCCGGTCGAAGATCCAGTGGCCCATGGCC
GTTTGGATGTGCAATTGGCCGCTGTGGCTCTGCGGGAAACCATTCCGGCCGTGGCGTTGGCCCTCTCGGTGGTGGGCCTG
GGTTTGATCCCTTCGGCCCTTTCACGAATTAGTGATTCCGCCACGCAACTGATGGCGCAACTGCCAGGAGGTATGGGCTA
A

Upstream 100 bases:

>100_bases
TGGTGTCGGCTGAAGGTCTGCGACTTGCTGTCAGTGGGCAGACCCAGTCCTATGTGCTGACGGTTCTGCTGGCCATCGTG
CTGCTGCTTTCAGCGCTGGT

Downstream 100 bases:

>100_bases
TGCCAGTCATTCCAGCCGAGCAGGTCCACGCCGGGCCCCATCCAACCCAGGAGCAGATCGTTCAAACCCTGCTCGCCGGC
CAAACCCTGCTGGATGACAC

Product: NAD(P)H-quinone oxidoreductase chain 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MVEGCLMLTALLLIPFLGGLLLLLLPSSVAPVRMRSVAIVFLSLQLLLSVALLIPFDPSVGTPQLVEFTPWVSRIGLDYR
LAVDGLSLPLILINAALTLVSAVCTRDFDQRPRIYFSMLLLISGAVNGAFLADNLLLFVIFYELELIPLWLLIAVWGGAN
RGYASTKFLIFTAVSGFLILAAFFGLALVSGSVNFNITPALTENLPVATQLVLLVTLLIGFGIKIPLVPFHVWLPDAHTQ
ASTPVSVMLAGVLLKLGTYGLLRFGLGLFQEVWPLVAPWLAIWAAISVLYGSLAAIAQSDMKRMVAFSSVGHMGYVLLAA
AAATPTALLGAVFQMVSHGVISALLFLLVGTVYRKTGTRDLSVIRGLLNPERGLPLTGTLMILGVMASAGLPGMAGFISE
FLVFQGSIQTFPLATLLSMVGSGLTAVYFLLLVNRAFFGRLAVTPVEDPVAHGRLDVQLAAVALRETIPAVALALSVVGL
GLIPSALSRISDSATQLMAQLPGGMG

Sequences:

>Translated_506_residues
MVEGCLMLTALLLIPFLGGLLLLLLPSSVAPVRMRSVAIVFLSLQLLLSVALLIPFDPSVGTPQLVEFTPWVSRIGLDYR
LAVDGLSLPLILINAALTLVSAVCTRDFDQRPRIYFSMLLLISGAVNGAFLADNLLLFVIFYELELIPLWLLIAVWGGAN
RGYASTKFLIFTAVSGFLILAAFFGLALVSGSVNFNITPALTENLPVATQLVLLVTLLIGFGIKIPLVPFHVWLPDAHTQ
ASTPVSVMLAGVLLKLGTYGLLRFGLGLFQEVWPLVAPWLAIWAAISVLYGSLAAIAQSDMKRMVAFSSVGHMGYVLLAA
AAATPTALLGAVFQMVSHGVISALLFLLVGTVYRKTGTRDLSVIRGLLNPERGLPLTGTLMILGVMASAGLPGMAGFISE
FLVFQGSIQTFPLATLLSMVGSGLTAVYFLLLVNRAFFGRLAVTPVEDPVAHGRLDVQLAAVALRETIPAVALALSVVGL
GLIPSALSRISDSATQLMAQLPGGMG
>Mature_506_residues
MVEGCLMLTALLLIPFLGGLLLLLLPSSVAPVRMRSVAIVFLSLQLLLSVALLIPFDPSVGTPQLVEFTPWVSRIGLDYR
LAVDGLSLPLILINAALTLVSAVCTRDFDQRPRIYFSMLLLISGAVNGAFLADNLLLFVIFYELELIPLWLLIAVWGGAN
RGYASTKFLIFTAVSGFLILAAFFGLALVSGSVNFNITPALTENLPVATQLVLLVTLLIGFGIKIPLVPFHVWLPDAHTQ
ASTPVSVMLAGVLLKLGTYGLLRFGLGLFQEVWPLVAPWLAIWAAISVLYGSLAAIAQSDMKRMVAFSSVGHMGYVLLAA
AAATPTALLGAVFQMVSHGVISALLFLLVGTVYRKTGTRDLSVIRGLLNPERGLPLTGTLMILGVMASAGLPGMAGFISE
FLVFQGSIQTFPLATLLSMVGSGLTAVYFLLLVNRAFFGRLAVTPVEDPVAHGRLDVQLAAVALRETIPAVALALSVVGL
GLIPSALSRISDSATQLMAQLPGGMG

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=337, Percent_Identity=31.4540059347181, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI251831117, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=512, Percent_Identity=36.5234375, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI1788827, Length=343, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788831, Length=195, Percent_Identity=37.9487179487179, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788829, Length=421, Percent_Identity=26.8408551068884, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693160, Length=344, Percent_Identity=31.1046511627907, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788614, Length=381, Percent_Identity=26.7716535433071, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI2367154, Length=314, Percent_Identity=26.1146496815287, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53590; Mature: 53590

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEGCLMLTALLLIPFLGGLLLLLLPSSVAPVRMRSVAIVFLSLQLLLSVALLIPFDPSV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTPQLVEFTPWVSRIGLDYRLAVDGLSLPLILINAALTLVSAVCTRDFDQRPRIYFSMLL
CCCCCEECCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LISGAVNGAFLADNLLLFVIFYELELIPLWLLIAVWGGANRGYASTKFLIFTAVSGFLIL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AAFFGLALVSGSVNFNITPALTENLPVATQLVLLVTLLIGFGIKIPLVPFHVWLPDAHTQ
HHHHHHHHHCCCCCEEECHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
ASTPVSVMLAGVLLKLGTYGLLRFGLGLFQEVWPLVAPWLAIWAAISVLYGSLAAIAQSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKRMVAFSSVGHMGYVLLAAAAATPTALLGAVFQMVSHGVISALLFLLVGTVYRKTGTRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LSVIRGLLNPERGLPLTGTLMILGVMASAGLPGMAGFISEFLVFQGSIQTFPLATLLSMV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GSGLTAVYFLLLVNRAFFGRLAVTPVEDPVAHGRLDVQLAAVALRETIPAVALALSVVGL
CCCHHHHHHHHHHHHHHHCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIPSALSRISDSATQLMAQLPGGMG
HHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVEGCLMLTALLLIPFLGGLLLLLLPSSVAPVRMRSVAIVFLSLQLLLSVALLIPFDPSV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GTPQLVEFTPWVSRIGLDYRLAVDGLSLPLILINAALTLVSAVCTRDFDQRPRIYFSMLL
CCCCCEECCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LISGAVNGAFLADNLLLFVIFYELELIPLWLLIAVWGGANRGYASTKFLIFTAVSGFLIL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AAFFGLALVSGSVNFNITPALTENLPVATQLVLLVTLLIGFGIKIPLVPFHVWLPDAHTQ
HHHHHHHHHCCCCCEEECHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
ASTPVSVMLAGVLLKLGTYGLLRFGLGLFQEVWPLVAPWLAIWAAISVLYGSLAAIAQSD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKRMVAFSSVGHMGYVLLAAAAATPTALLGAVFQMVSHGVISALLFLLVGTVYRKTGTRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LSVIRGLLNPERGLPLTGTLMILGVMASAGLPGMAGFISEFLVFQGSIQTFPLATLLSMV
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
GSGLTAVYFLLLVNRAFFGRLAVTPVEDPVAHGRLDVQLAAVALRETIPAVALALSVVGL
CCCHHHHHHHHHHHHHHHCCEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIPSALSRISDSATQLMAQLPGGMG
HHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]