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The map label for this gene is proC [H]

Identifier: 148241570

GI number: 148241570

Start: 439480

End: 440322

Strand: Direct

Name: proC [H]

Synonym: SynRCC307_0471

Alternate gene names: 148241570

Gene position: 439480-440322 (Clockwise)

Preceding gene: 148241569

Following gene: 148241573

Centisome position: 19.75

GC content: 63.35

Gene sequence:

>843_bases
ATGCCATCAACGGCTGATTCGCAATTGAGCTTTGGTGTGATTGGCCTGGGCCGCATGGCCCAGGCGCTCCTGACTCCTTG
GCTTGAGGCTGGCTTGCTGCAACGCGAGCAGCTGCAACTCTCGGTGGCCTCTGAGTCCTCGGCGCAAGCGTTGCGTCAGC
GCTTTGATTGTCCGGTCCACACCGACCCAAGCGCTTGTTTGGCTGTTTCGGAGTTGTTGTTGGCCCTCAAGCCGCAGCAG
CTCGATGGCTTGGTGGAGCAATTGGGAGGCCGATCGGCGATTGCCGCTGCTGCAGCGAGCCGATCCGAGCCTCCGCTGCT
CATCTCTGTGTTGGCTGGTGTGAGCTCAGAGCGCTTGCAGGATTGCTTTCCGGGTTGGCGGGTGGTGCGCACCGTGCCCA
ACACGCCTGCGTTGGTGAGGCAGGGTCTGGTGGGGTTGGCGTTCGCTGATGGGGTGAGCGCTGAGCAGCAGCAGCGCGTG
CAGACCTTGTTTGCCGCGGTGGGTGAGGTGCTCGAACTTCCCGAGAGTCAGCTGCCTGCATTTTTGGCGTTGACCTCATC
AGGCCCGGCTTTTGTGGCGTTGGTGGCCGAAGCCCTCGCCGATGGAGCCGTTGCCGCCGGATTGCCTCGCGCCCGTGCCC
ATCACCTGGCCCATCGCACACTCGCGGGAACGGCTGCCTTGTTGTTTGAGCAGGACCTGCACCCCGGAGAACTCAAAGAC
ATGGTCAGCAGTCCGGCGGGCGCCACGATCGCCGGTATCCGTGTGCTGGAGCAATCGCAGTTGCGTTCAGCGTTGATGGA
GGCGGTGGTGCGTGCGGCTGATCGCAGCCGCGAACTCGGTTAG

Upstream 100 bases:

>100_bases
ACCACCGCTAGCAGTGAAGAATCCGCTGCCCCCAGCGTGATGGCACGCGAAGAAGAAGCAACAGCACCGGCGGCTCCGAG
CCCTGCTTGGGGCACGCAGG

Downstream 100 bases:

>100_bases
TCCTTTTGCCCCAGCCGCGGCTCTTCGCCTTTGAGGAGCCTGCTCAGGTTGCTGCGGTGCCGCCAAATCACCATCACCGC
GGCCACAACACCCAAGCCGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MPSTADSQLSFGVIGLGRMAQALLTPWLEAGLLQREQLQLSVASESSAQALRQRFDCPVHTDPSACLAVSELLLALKPQQ
LDGLVEQLGGRSAIAAAAASRSEPPLLISVLAGVSSERLQDCFPGWRVVRTVPNTPALVRQGLVGLAFADGVSAEQQQRV
QTLFAAVGEVLELPESQLPAFLALTSSGPAFVALVAEALADGAVAAGLPRARAHHLAHRTLAGTAALLFEQDLHPGELKD
MVSSPAGATIAGIRVLEQSQLRSALMEAVVRAADRSRELG

Sequences:

>Translated_280_residues
MPSTADSQLSFGVIGLGRMAQALLTPWLEAGLLQREQLQLSVASESSAQALRQRFDCPVHTDPSACLAVSELLLALKPQQ
LDGLVEQLGGRSAIAAAAASRSEPPLLISVLAGVSSERLQDCFPGWRVVRTVPNTPALVRQGLVGLAFADGVSAEQQQRV
QTLFAAVGEVLELPESQLPAFLALTSSGPAFVALVAEALADGAVAAGLPRARAHHLAHRTLAGTAALLFEQDLHPGELKD
MVSSPAGATIAGIRVLEQSQLRSALMEAVVRAADRSRELG
>Mature_279_residues
PSTADSQLSFGVIGLGRMAQALLTPWLEAGLLQREQLQLSVASESSAQALRQRFDCPVHTDPSACLAVSELLLALKPQQL
DGLVEQLGGRSAIAAAAASRSEPPLLISVLAGVSSERLQDCFPGWRVVRTVPNTPALVRQGLVGLAFADGVSAEQQQRVQ
TLFAAVGEVLELPESQLPAFLALTSSGPAFVALVAEALADGAVAAGLPRARAHHLAHRTLAGTAALLFEQDLHPGELKDM
VSSPAGATIAGIRVLEQSQLRSALMEAVVRAADRSRELG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=33.7037037037037, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI24797097, Length=280, Percent_Identity=33.9285714285714, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797095, Length=280, Percent_Identity=33.9285714285714, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI21361454, Length=277, Percent_Identity=32.129963898917, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=30.1470588235294, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17569021, Length=279, Percent_Identity=31.8996415770609, Blast_Score=136, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17540664, Length=302, Percent_Identity=31.1258278145695, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=290, Percent_Identity=30.6896551724138, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=34.4086021505376, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=33.4558823529412, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24647700, Length=156, Percent_Identity=41.6666666666667, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29282; Mature: 29151

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTADSQLSFGVIGLGRMAQALLTPWLEAGLLQREQLQLSVASESSAQALRQRFDCPVH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
TDPSACLAVSELLLALKPQQLDGLVEQLGGRSAIAAAAASRSEPPLLISVLAGVSSERLQ
CCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHH
DCFPGWRVVRTVPNTPALVRQGLVGLAFADGVSAEQQQRVQTLFAAVGEVLELPESQLPA
HHCCCCEEEEECCCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCE
FLALTSSGPAFVALVAEALADGAVAAGLPRARAHHLAHRTLAGTAALLFEQDLHPGELKD
EEEEECCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MVSSPAGATIAGIRVLEQSQLRSALMEAVVRAADRSRELG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSTADSQLSFGVIGLGRMAQALLTPWLEAGLLQREQLQLSVASESSAQALRQRFDCPVH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
TDPSACLAVSELLLALKPQQLDGLVEQLGGRSAIAAAAASRSEPPLLISVLAGVSSERLQ
CCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHH
DCFPGWRVVRTVPNTPALVRQGLVGLAFADGVSAEQQQRVQTLFAAVGEVLELPESQLPA
HHCCCCEEEEECCCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCE
FLALTSSGPAFVALVAEALADGAVAAGLPRARAHHLAHRTLAGTAALLFEQDLHPGELKD
EEEEECCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
MVSSPAGATIAGIRVLEQSQLRSALMEAVVRAADRSRELG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]