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The map label for this gene is hemK [C]

Identifier: 148241523

GI number: 148241523

Start: 403936

End: 404820

Strand: Direct

Name: hemK [C]

Synonym: SynRCC307_0424

Alternate gene names: 148241523

Gene position: 403936-404820 (Clockwise)

Preceding gene: 148241522

Following gene: 148241524

Centisome position: 18.16

GC content: 64.86

Gene sequence:

>885_bases
ATGACTTGCCTCAGCGGCTCCGAGTTGCAGCTCTGGCGGCGTGAGCAATTGCTGGGCCAGCAGGAGCAAGCGGCCGCGCT
GGATTGGTTGCTGGAGCTGGAAGCAGGTCTGCGGTGGCGGGAGCTTCAAGCCAGCTATCTCCACCCTGAAGCCCCTGTGC
AGCTGGATTGTTCGCTACAGCGGCTGGAGCAGATCTGGCAGCAGCACTGCCAGCAGCAGGTGCCCTTGCAGCATCTGGTG
GGGCGTTGTCCCTGGCGGGATTTTGAGCTGGAAGTCAGCCCAGCGGTGCTGATCCCCCGTCAGGAAACCGAGCTGTTGGT
GGAGCTGGCGATGGGCTGTTTTGAAGCTTCCGACGCACCCCAGCGCTGGGCGGATCTCGGCACGGGCTCAGGTTGTCTGG
CTGTGGCCTTGGCGCGGCATTGGCCCAGCAGCTGCGGCTGGGCTGTCGACTGCAGCCGCGAGGCCTTGGCTGTGGCCCGG
CGCAACGCAGCAGCGCTTGGACTGCTTCAAAGCGCTGCGTTGCAGTGGTGTGAGGGGCTGTGGTGGCAGCCCTTGCAGCC
TCTGGCGGGCCAGTTGGATCTGGTGGTGAGCAATCCTCCCTATATCCCCAGTGCCGTGGTGGATGGCCTGGAGCCTGTGG
TGCGCGATCACGAGCCGCGCTTGGCGTTGGATGGAGGCAGCGATGGCTTGGATGCCTTGCGTTTGATCATCGAGGCAGCC
CCGCAAATGCTGGCCCCGGGGGGATGGTTGGTGCTTGAGCACCATCACGATCAAGCTGCTGCGGTGGCTGAGCTCTTGGG
CGCTGCCGGCCTGCAGGAGCGCCGTCAGGAGAGGGATCTGGAGGGGCAAATGCGTTTTGCGGTGGTGCGCCGCTCCAACC
CATGA

Upstream 100 bases:

>100_bases
AACTGCTGCACCATCAGCAGCAGGGCTGGATTGAAGCTCTGCCTGGGTTGTGCTGGCGTCCGCGTCACACTGAGATTGAT
CTGCCTGTGGCCTAGCAGCC

Downstream 100 bases:

>100_bases
CGGCGGAAGGGTTCCAGGTGCTGGCGCAGCGGTTGCAACAGGGGGAGCCGGCCCTGTTCCCCACCGACACCTTGCCGGCA
TTGGCCGCGATTCCATCTGC

Product: protoporphyrinogen oxidase

Products: Protoporphyrin IX; H2O

Alternate protein names: M.Ssp6803HemKP [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTCLSGSELQLWRREQLLGQQEQAAALDWLLELEAGLRWRELQASYLHPEAPVQLDCSLQRLEQIWQQHCQQQVPLQHLV
GRCPWRDFELEVSPAVLIPRQETELLVELAMGCFEASDAPQRWADLGTGSGCLAVALARHWPSSCGWAVDCSREALAVAR
RNAAALGLLQSAALQWCEGLWWQPLQPLAGQLDLVVSNPPYIPSAVVDGLEPVVRDHEPRLALDGGSDGLDALRLIIEAA
PQMLAPGGWLVLEHHHDQAAAVAELLGAAGLQERRQERDLEGQMRFAVVRRSNP

Sequences:

>Translated_294_residues
MTCLSGSELQLWRREQLLGQQEQAAALDWLLELEAGLRWRELQASYLHPEAPVQLDCSLQRLEQIWQQHCQQQVPLQHLV
GRCPWRDFELEVSPAVLIPRQETELLVELAMGCFEASDAPQRWADLGTGSGCLAVALARHWPSSCGWAVDCSREALAVAR
RNAAALGLLQSAALQWCEGLWWQPLQPLAGQLDLVVSNPPYIPSAVVDGLEPVVRDHEPRLALDGGSDGLDALRLIIEAA
PQMLAPGGWLVLEHHHDQAAAVAELLGAAGLQERRQERDLEGQMRFAVVRRSNP
>Mature_293_residues
TCLSGSELQLWRREQLLGQQEQAAALDWLLELEAGLRWRELQASYLHPEAPVQLDCSLQRLEQIWQQHCQQQVPLQHLVG
RCPWRDFELEVSPAVLIPRQETELLVELAMGCFEASDAPQRWADLGTGSGCLAVALARHWPSSCGWAVDCSREALAVARR
NAAALGLLQSAALQWCEGLWWQPLQPLAGQLDLVVSNPPYIPSAVVDGLEPVVRDHEPRLALDGGSDGLDALRLIIEAAP
QMLAPGGWLVLEHHHDQAAAVAELLGAAGLQERRQERDLEGQMRFAVVRRSNP

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=241, Percent_Identity=30.2904564315353, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787463, Length=218, Percent_Identity=36.697247706422, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082085, Length=194, Percent_Identity=32.4742268041237, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24582226, Length=211, Percent_Identity=32.7014218009479, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 1.3.3.4

Molecular weight: Translated: 32585; Mature: 32454

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCLSGSELQLWRREQLLGQQEQAAALDWLLELEAGLRWRELQASYLHPEAPVQLDCSLQ
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCHH
RLEQIWQQHCQQQVPLQHLVGRCPWRDFELEVSPAVLIPRQETELLVELAMGCFEASDAP
HHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCEEEECCHHHHHHHHHHHHHHCCCCCH
QRWADLGTGSGCLAVALARHWPSSCGWAVDCSREALAVARRNAAALGLLQSAALQWCEGL
HHHHHCCCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WWQPLQPLAGQLDLVVSNPPYIPSAVVDGLEPVVRDHEPRLALDGGSDGLDALRLIIEAA
CCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
PQMLAPGGWLVLEHHHDQAAAVAELLGAAGLQERRQERDLEGQMRFAVVRRSNP
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
TCLSGSELQLWRREQLLGQQEQAAALDWLLELEAGLRWRELQASYLHPEAPVQLDCSLQ
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCHH
RLEQIWQQHCQQQVPLQHLVGRCPWRDFELEVSPAVLIPRQETELLVELAMGCFEASDAP
HHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECCCEEEECCHHHHHHHHHHHHHHCCCCCH
QRWADLGTGSGCLAVALARHWPSSCGWAVDCSREALAVARRNAAALGLLQSAALQWCEGL
HHHHHCCCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
WWQPLQPLAGQLDLVVSNPPYIPSAVVDGLEPVVRDHEPRLALDGGSDGLDALRLIIEAA
CCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
PQMLAPGGWLVLEHHHDQAAAVAELLGAAGLQERRQERDLEGQMRFAVVRRSNP
HHHHCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Protoporphyrinogen IX; O2

Specific reaction: protoporphyrinogen-IX + 1.5 O2 = protoporphyrin-IX + 3 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]