Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 148241324

GI number: 148241324

Start: 225315

End: 226718

Strand: Direct

Name: phr [H]

Synonym: SynRCC307_0225

Alternate gene names: 148241324

Gene position: 225315-226718 (Clockwise)

Preceding gene: 148241323

Following gene: 148241326

Centisome position: 10.13

GC content: 62.82

Gene sequence:

>1404_bases
ATGGGCCCCTGGCTGTTCTGGCATCGCCGTGATCTGCGCTTGGCCGACAACCTCGGCTTGGCGGCGGTGAGCGCGATCAC
GCCTGAGGTGATGGGCGTGTTTGTGTTGGATCCAGCCGAACTGGAGCACCCGACCATGGCTCCGGCGCGCCGCTGGTTTT
TGCTGGAAAGCCTGCGGGAGCTGCAGCAGCGCTGGCGGCAGGCCGGCAGCCAACTGCTGCTGCTAGAGGGCAATCCTGTT
GAGCTGTTGCCCCGCCTGGCTCAGCAACTCGGAGCTGCTGGTGTGGCGTGGAACCGGGATGTGGAGCCCTTGGTGCGCCA
GCGCGACCGTGAGCTGGCCGCGGCGCTGAAGGCCATCGGTGTGCGAGTTGCAGCGGATTGGGATCAGTTGCTGGTGCCAC
CAGAGCAGCTCAAAACCGGCGGCGGGGATCCCTACCGGGTGTATGGGCCCTATTGGCGCAGTTGGGAGAAGCAGCCCAAG
GCCAAGCCTGTGCCGGCGCCATCAGAGCTAAAGGCTTTGCTCAAGCCAGATCTCAGCGGCTTGCCTGTGCTGAATGAGGT
GCCCGTCGAGCCTTGGGAAGGGGCTGACCTGTGTCCATGTCGCCCAGGCGAAACAGCAGCTCTGGAGCAATTGGAGCACT
TTGCAGCCCGCGCCATGGAGCACTACTGCGAAGGCCGCAACTTGCCTGGGGATGAAGGCACCTCGACTCTCAGTGCGGCT
CTGCGGGCTGGCAGCCTCAGCCCGCGCACGGCGTGGGCCGCCAGCTTGGATGTGTGGTCGCACTGCCGCAGTGATGAACA
GCGGCAGTCGGTAACGGTGTGGCAGCAGGAATTGGCATGGCGGGAGTTCTATCAGCAGGCTCTGTTCCATTTCCCGGAAT
TGGCGGATGGCCCCTACCGGCCGCAATGGCGCCAGTTCCCCTGGGAAGACGACCCCGTGCGCCTAAAGGCTTGGCAAGAC
GGGCTGACGGGTGTGCCGATTGTGGATGCCGCCATGCGGCAGTTGGTGCAAACCGGCTTCATGCACAACCGTTGCCGCAT
GATCGTGGCTTCGTTTTTGGTTAAAGATCTGATCTGTGATTGGCGCCATGGGGAGGCCTTCTTCATGGCCCATGAAGTGG
ATGGCGATCTGGCAGCCAACAATGGCGGCTGGCAGTGGAGCGCCAGCAGTGGCATGGATCCCAAACCGCTGCGGATCTTC
AATCCCTTCACTCAAGCCAGCAAATTTGATCCAGAGGCGACCTACATCCGCCGCTGGTTGCCGGAGCTCGCCCACATCAA
CACCAAGGACCTCATTAGCGGGGATATCGGAGCACTTGAGCGACGCGGTTACCCCGAGCCGATCGTGAACCACAAGCAAC
AGCAGGCCCGCTTTAAGGCGTTGTATGCGGCACTGCCGCGCTGA

Upstream 100 bases:

>100_bases
CCGAAGAGCTCGATGCAGCCCTCGCCAGTGGCGATGAGGCCCTTGATGGCAAATCCGTCACGGCTTGGTACCGGGCCAAA
CAGGTGCTGGGGCTCGGTTA

Downstream 100 bases:

>100_bases
TTAACCCTCGTCGGGAAGGTTGCAGCAGTTGAAGCCGTCTTTGCAGATCTTGCCGTTGGAGAGCGCCCAGTTCACCAGGG
CAACCCGGTTGCGGGAGCCG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MGPWLFWHRRDLRLADNLGLAAVSAITPEVMGVFVLDPAELEHPTMAPARRWFLLESLRELQQRWRQAGSQLLLLEGNPV
ELLPRLAQQLGAAGVAWNRDVEPLVRQRDRELAAALKAIGVRVAADWDQLLVPPEQLKTGGGDPYRVYGPYWRSWEKQPK
AKPVPAPSELKALLKPDLSGLPVLNEVPVEPWEGADLCPCRPGETAALEQLEHFAARAMEHYCEGRNLPGDEGTSTLSAA
LRAGSLSPRTAWAASLDVWSHCRSDEQRQSVTVWQQELAWREFYQQALFHFPELADGPYRPQWRQFPWEDDPVRLKAWQD
GLTGVPIVDAAMRQLVQTGFMHNRCRMIVASFLVKDLICDWRHGEAFFMAHEVDGDLAANNGGWQWSASSGMDPKPLRIF
NPFTQASKFDPEATYIRRWLPELAHINTKDLISGDIGALERRGYPEPIVNHKQQQARFKALYAALPR

Sequences:

>Translated_467_residues
MGPWLFWHRRDLRLADNLGLAAVSAITPEVMGVFVLDPAELEHPTMAPARRWFLLESLRELQQRWRQAGSQLLLLEGNPV
ELLPRLAQQLGAAGVAWNRDVEPLVRQRDRELAAALKAIGVRVAADWDQLLVPPEQLKTGGGDPYRVYGPYWRSWEKQPK
AKPVPAPSELKALLKPDLSGLPVLNEVPVEPWEGADLCPCRPGETAALEQLEHFAARAMEHYCEGRNLPGDEGTSTLSAA
LRAGSLSPRTAWAASLDVWSHCRSDEQRQSVTVWQQELAWREFYQQALFHFPELADGPYRPQWRQFPWEDDPVRLKAWQD
GLTGVPIVDAAMRQLVQTGFMHNRCRMIVASFLVKDLICDWRHGEAFFMAHEVDGDLAANNGGWQWSASSGMDPKPLRIF
NPFTQASKFDPEATYIRRWLPELAHINTKDLISGDIGALERRGYPEPIVNHKQQQARFKALYAALPR
>Mature_466_residues
GPWLFWHRRDLRLADNLGLAAVSAITPEVMGVFVLDPAELEHPTMAPARRWFLLESLRELQQRWRQAGSQLLLLEGNPVE
LLPRLAQQLGAAGVAWNRDVEPLVRQRDRELAAALKAIGVRVAADWDQLLVPPEQLKTGGGDPYRVYGPYWRSWEKQPKA
KPVPAPSELKALLKPDLSGLPVLNEVPVEPWEGADLCPCRPGETAALEQLEHFAARAMEHYCEGRNLPGDEGTSTLSAAL
RAGSLSPRTAWAASLDVWSHCRSDEQRQSVTVWQQELAWREFYQQALFHFPELADGPYRPQWRQFPWEDDPVRLKAWQDG
LTGVPIVDAAMRQLVQTGFMHNRCRMIVASFLVKDLICDWRHGEAFFMAHEVDGDLAANNGGWQWSASSGMDPKPLRIFN
PFTQASKFDPEATYIRRWLPELAHINTKDLISGDIGALERRGYPEPIVNHKQQQARFKALYAALPR

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=492, Percent_Identity=29.0650406504065, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4758072, Length=491, Percent_Identity=28.3095723014257, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI188536103, Length=445, Percent_Identity=28.9887640449438, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI1786926, Length=483, Percent_Identity=37.888198757764, Blast_Score=273, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324962, Length=501, Percent_Identity=28.3433133732535, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17137248, Length=446, Percent_Identity=29.1479820627803, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585455, Length=446, Percent_Identity=29.1479820627803, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24648152, Length=460, Percent_Identity=25.4347826086956, Blast_Score=131, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52870; Mature: 52739

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPWLFWHRRDLRLADNLGLAAVSAITPEVMGVFVLDPAELEHPTMAPARRWFLLESLRE
CCCCEEEECCCCCHHHCCCHHHHHHHCHHHHEEEEECCHHCCCCCCHHHHHHHHHHHHHH
LQQRWRQAGSQLLLLEGNPVELLPRLAQQLGAAGVAWNRDVEPLVRQRDRELAAALKAIG
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
VRVAADWDQLLVPPEQLKTGGGDPYRVYGPYWRSWEKQPKAKPVPAPSELKALLKPDLSG
CCEECCHHHHCCCHHHHHCCCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
LPVLNEVPVEPWEGADLCPCRPGETAALEQLEHFAARAMEHYCEGRNLPGDEGTSTLSAA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRAGSLSPRTAWAASLDVWSHCRSDEQRQSVTVWQQELAWREFYQQALFHFPELADGPYR
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PQWRQFPWEDDPVRLKAWQDGLTGVPIVDAAMRQLVQTGFMHNRCRMIVASFLVKDLICD
CCCCCCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WRHGEAFFMAHEVDGDLAANNGGWQWSASSGMDPKPLRIFNPFTQASKFDPEATYIRRWL
CCCCCEEEEEEECCCCEEECCCCEEECCCCCCCCCCCEEECCHHHHCCCCCHHHHHHHHH
PELAHINTKDLISGDIGALERRGYPEPIVNHKQQQARFKALYAALPR
HHHHCCCHHHHHCCCHHHHHHCCCCCHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GPWLFWHRRDLRLADNLGLAAVSAITPEVMGVFVLDPAELEHPTMAPARRWFLLESLRE
CCCEEEECCCCCHHHCCCHHHHHHHCHHHHEEEEECCHHCCCCCCHHHHHHHHHHHHHH
LQQRWRQAGSQLLLLEGNPVELLPRLAQQLGAAGVAWNRDVEPLVRQRDRELAAALKAIG
HHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
VRVAADWDQLLVPPEQLKTGGGDPYRVYGPYWRSWEKQPKAKPVPAPSELKALLKPDLSG
CCEECCHHHHCCCHHHHHCCCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHCCCCCC
LPVLNEVPVEPWEGADLCPCRPGETAALEQLEHFAARAMEHYCEGRNLPGDEGTSTLSAA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LRAGSLSPRTAWAASLDVWSHCRSDEQRQSVTVWQQELAWREFYQQALFHFPELADGPYR
HHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PQWRQFPWEDDPVRLKAWQDGLTGVPIVDAAMRQLVQTGFMHNRCRMIVASFLVKDLICD
CCCCCCCCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WRHGEAFFMAHEVDGDLAANNGGWQWSASSGMDPKPLRIFNPFTQASKFDPEATYIRRWL
CCCCCEEEEEEECCCCEEECCCCEEECCCCCCCCCCCEEECCHHHHCCCCCHHHHHHHHH
PELAHINTKDLISGDIGALERRGYPEPIVNHKQQQARFKALYAALPR
HHHHCCCHHHHHCCCHHHHHHCCCCCHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]