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The map label for this gene is lpxD [H]

Identifier: 148241295

GI number: 148241295

Start: 197319

End: 198263

Strand: Direct

Name: lpxD [H]

Synonym: SynRCC307_0196

Alternate gene names: 148241295

Gene position: 197319-198263 (Clockwise)

Preceding gene: 148241294

Following gene: 148241296

Centisome position: 8.87

GC content: 36.08

Gene sequence:

>945_bases
ATGATTCCTTTTAGAGAAAAACGACAGTTCATCAGTGCCGAAAGCAAGACTTTGGACGTGAGGGGAGTTTGTCTCCCATC
AGACCTTTCACCTGGATGCCTTGCTTTTACTAATTCATTTGAGTCGTACCCAATCAAATTTAAAGATACTTATAAAGCTT
CTGCTGTTTCATCTATTACTAAGATTCTAACTACATATATCTTTATTTCAGATAGAGATTTTTCGGAAAATCCAAGCGTC
AAAGAAGATTTAAAAGAAAAATGCATAGAGTTAATACCTGTAACCAATCCAAGAGATCACTTTATTTTTGCCATTAATTC
TAATTCGTATGCAATAGATTTTAAAAGTTTATTAGGTAAAAATCCTTCGATTCACTCGTCTGCACACATCCATCCTTCAG
CTTTTATTTCAGAAAATGTATATATCGATTCTGGCGTCACCGTTGGCCCAGGCTGTGTCATTGGTGAAGGAACTTATATT
GGTAAGAATACAATTATCCAATCTAATTGTACGATTGGCTGTGATGGGATTAATGCATATAATTCCTCGATAACAAATAA
ACTGACCATGATGCCTCATTTCTCTGGTGTGTTTATTGGTGAAAATGTTTATATTGGCTCAGGCTCGACAATCAATCGTG
GCGTTTTTAATATGACTATGATTTCAAATCATTGCATTCTTGGATCTAATGTACTTATTGGCCATAATGCTTCCCTTGAT
AATAAAGTATGGTTGTCTTCAGGAGTTCTCGTTGGAGGTGGCTCGCATTTATCTGAATGTACAAAGATAGGATTAGGTGC
AATCATTAGGGATAATCTAAGTATTGGCTCAAATGTAAATGTAGGAATGGGATCAGTAGTATATAAAAATGTACTTGCGA
ATAGATCATTGATCGGAAACCCGGCACGGATCACTCCAAAACTGAGTGCAGGGCCAGATTTTTAA

Upstream 100 bases:

>100_bases
CAGAAGTTGAGTCTGAAACAGGAATATCCATTGAGGATGATGAGCTTCAAGAATTAAAAACTCCTGCTCAACTGCTACAT
CTCATAACTTCTAAACAATA

Downstream 100 bases:

>100_bases
TATATATAGAAAATTTTATAGAGTAAGCCTCTCAGCTTACCATTGGTCGGTAAAATATCTTCGCCGATAGTTCACTGCTT
CATTTTCTTTCTAGCTCACT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIPFREKRQFISAESKTLDVRGVCLPSDLSPGCLAFTNSFESYPIKFKDTYKASAVSSITKILTTYIFISDRDFSENPSV
KEDLKEKCIELIPVTNPRDHFIFAINSNSYAIDFKSLLGKNPSIHSSAHIHPSAFISENVYIDSGVTVGPGCVIGEGTYI
GKNTIIQSNCTIGCDGINAYNSSITNKLTMMPHFSGVFIGENVYIGSGSTINRGVFNMTMISNHCILGSNVLIGHNASLD
NKVWLSSGVLVGGGSHLSECTKIGLGAIIRDNLSIGSNVNVGMGSVVYKNVLANRSLIGNPARITPKLSAGPDF

Sequences:

>Translated_314_residues
MIPFREKRQFISAESKTLDVRGVCLPSDLSPGCLAFTNSFESYPIKFKDTYKASAVSSITKILTTYIFISDRDFSENPSV
KEDLKEKCIELIPVTNPRDHFIFAINSNSYAIDFKSLLGKNPSIHSSAHIHPSAFISENVYIDSGVTVGPGCVIGEGTYI
GKNTIIQSNCTIGCDGINAYNSSITNKLTMMPHFSGVFIGENVYIGSGSTINRGVFNMTMISNHCILGSNVLIGHNASLD
NKVWLSSGVLVGGGSHLSECTKIGLGAIIRDNLSIGSNVNVGMGSVVYKNVLANRSLIGNPARITPKLSAGPDF
>Mature_314_residues
MIPFREKRQFISAESKTLDVRGVCLPSDLSPGCLAFTNSFESYPIKFKDTYKASAVSSITKILTTYIFISDRDFSENPSV
KEDLKEKCIELIPVTNPRDHFIFAINSNSYAIDFKSLLGKNPSIHSSAHIHPSAFISENVYIDSGVTVGPGCVIGEGTYI
GKNTIIQSNCTIGCDGINAYNSSITNKLTMMPHFSGVFIGENVYIGSGSTINRGVFNMTMISNHCILGSNVLIGHNASLD
NKVWLSSGVLVGGGSHLSECTKIGLGAIIRDNLSIGSNVNVGMGSVVYKNVLANRSLIGNPARITPKLSAGPDF

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=192, Percent_Identity=31.25, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 33743; Mature: 33743

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPFREKRQFISAESKTLDVRGVCLPSDLSPGCLAFTNSFESYPIKFKDTYKASAVSSIT
CCCCHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHH
KILTTYIFISDRDFSENPSVKEDLKEKCIELIPVTNPRDHFIFAINSNSYAIDFKSLLGK
HHHHEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCCCCCEEEEECCCCEEEEHHHHHCC
NPSIHSSAHIHPSAFISENVYIDSGVTVGPGCVIGEGTYIGKNTIIQSNCTIGCDGINAY
CCCCCCCCCCCCHHEEECCEEEECCCEECCCEEEECCEEECCCEEEECCCEEEECCCCHH
NSSITNKLTMMPHFSGVFIGENVYIGSGSTINRGVFNMTMISNHCILGSNVLIGHNASLD
CCCCCCEEEECCCCCCEEEECEEEECCCCCCCCCEEEEEEEECCEEECCCEEEECCCCCC
NKVWLSSGVLVGGGSHLSECTKIGLGAIIRDNLSIGSNVNVGMGSVVYKNVLANRSLIGN
CEEEEECCEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
PARITPKLSAGPDF
CCEECCCCCCCCCC
>Mature Secondary Structure
MIPFREKRQFISAESKTLDVRGVCLPSDLSPGCLAFTNSFESYPIKFKDTYKASAVSSIT
CCCCHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHH
KILTTYIFISDRDFSENPSVKEDLKEKCIELIPVTNPRDHFIFAINSNSYAIDFKSLLGK
HHHHEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCCCCCEEEEECCCCEEEEHHHHHCC
NPSIHSSAHIHPSAFISENVYIDSGVTVGPGCVIGEGTYIGKNTIIQSNCTIGCDGINAY
CCCCCCCCCCCCHHEEECCEEEECCCEECCCEEEECCEEECCCEEEECCCEEEECCCCHH
NSSITNKLTMMPHFSGVFIGENVYIGSGSTINRGVFNMTMISNHCILGSNVLIGHNASLD
CCCCCCEEEECCCCCCEEEECEEEECCCCCCCCCEEEEEEEECCEEECCCEEEECCCCCC
NKVWLSSGVLVGGGSHLSECTKIGLGAIIRDNLSIGSNVNVGMGSVVYKNVLANRSLIGN
CEEEEECCEEEECCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
PARITPKLSAGPDF
CCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA