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The map label for this gene is cysK [H]

Identifier: 148241220

GI number: 148241220

Start: 116218

End: 117219

Strand: Direct

Name: cysK [H]

Synonym: SynRCC307_0121

Alternate gene names: 148241220

Gene position: 116218-117219 (Clockwise)

Preceding gene: 148241214

Following gene: 148241221

Centisome position: 5.22

GC content: 61.38

Gene sequence:

>1002_bases
ATGGGGATCACTCGCGGATTCGTTGGAGCGGTGGGCAACACCCCGCTGATTCGCCTGGAGCATCTCAGCGAGTGCACCGG
CTGCGAAATCCTCGGCAAGGCTGAGTTCATGAACCCTGGCGGTTCGGTCAAAGACCGTGCTGCGCTGGGAATTCTTTTGG
CTGCCGAAGCCAGTGGTGACCTCAAAGCAGGCGGCACCGTTGTCGAGGGAACAGCCGGGAACACCGGCATTGGTTTGGCC
CATCTCTGCAATGCCCGCGGCTACCGCTGCGTGATCGTGATCCCAGAAACGCAGTCGGCCGAAAAGATCGACCTGCTGCG
CAGCCTTGGGGCTGAAGTGCGCACAGTGCCTGCCGTGCCGTACCGGGATCCCAACAACTACGTGAAACTCTCAGGCCGGA
TCGCTGAGGAGATTCCCGGTGCGGTTTGGGCCAATCAATTTGATAACCGCGCCAACCGTCAGGCCCATGCCGACACCACT
GGTCCGGAAATCTGGCAGCAATGCGAAGGCCGGCTGGATGGCTGGGTGGCTGCAACAGGCACTGGTGGCACCTACGCCGG
CGTGGCGCTTTACCTCAAGCAGCAATCCGATGCTGTGCGCTGCGTGCTGGCCGATCCCCATGGCAGTGCCCTCTACAGCT
GGGCCAGCAATGGGGAATTGGCCAGTGAAGGTTCGTCGGTGACCGAGGGCATCGGCAACAGCCGCATCACCGCCAATTTG
GAGGGGGCTCCCGTCGATGAGGCGATCCGCATCGATGATCAGACCGCCATTGATGTGCTTTACGACCTCCTTTGGCATGA
AGGTCTGTTCTTGGGTGGTTCGGTCGGGATCAATGTGGCCGCGGCTGTTGAGTTGGCCCGGCGCTTAGGGCCTGGACATC
GCATCGTCACGGTGTTGTGTGATGGCGGTGATCGCTATCGCTCCCGCATTTGGAATCAGGAGTGGTTGCAAAGCCGGGGG
CTGCGCCAGCCAGAGCGGCAGCAACTCGGTAGCGTCGCTTAA

Upstream 100 bases:

>100_bases
CGCGCTCAAGCGCTCGAGCACCGGCGCTGGGGAGTGTCGGATCATCCTCAGGGCGCCCGGTGGCGGGACCCTAGCCTGCG
CAAACGCAGTCGACAGCAGG

Downstream 100 bases:

>100_bases
GAGCCAGAAGAGTGGCCGTGCCGACCCCTGCTGAGGCCGCCAGCGGAGCCTTGCTTGAGCGCCGTTATCGCCTCGATGAG
GTTCTCAGCGAGGCTGAGGG

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MGITRGFVGAVGNTPLIRLEHLSECTGCEILGKAEFMNPGGSVKDRAALGILLAAEASGDLKAGGTVVEGTAGNTGIGLA
HLCNARGYRCVIVIPETQSAEKIDLLRSLGAEVRTVPAVPYRDPNNYVKLSGRIAEEIPGAVWANQFDNRANRQAHADTT
GPEIWQQCEGRLDGWVAATGTGGTYAGVALYLKQQSDAVRCVLADPHGSALYSWASNGELASEGSSVTEGIGNSRITANL
EGAPVDEAIRIDDQTAIDVLYDLLWHEGLFLGGSVGINVAAAVELARRLGPGHRIVTVLCDGGDRYRSRIWNQEWLQSRG
LRQPERQQLGSVA

Sequences:

>Translated_333_residues
MGITRGFVGAVGNTPLIRLEHLSECTGCEILGKAEFMNPGGSVKDRAALGILLAAEASGDLKAGGTVVEGTAGNTGIGLA
HLCNARGYRCVIVIPETQSAEKIDLLRSLGAEVRTVPAVPYRDPNNYVKLSGRIAEEIPGAVWANQFDNRANRQAHADTT
GPEIWQQCEGRLDGWVAATGTGGTYAGVALYLKQQSDAVRCVLADPHGSALYSWASNGELASEGSSVTEGIGNSRITANL
EGAPVDEAIRIDDQTAIDVLYDLLWHEGLFLGGSVGINVAAAVELARRLGPGHRIVTVLCDGGDRYRSRIWNQEWLQSRG
LRQPERQQLGSVA
>Mature_332_residues
GITRGFVGAVGNTPLIRLEHLSECTGCEILGKAEFMNPGGSVKDRAALGILLAAEASGDLKAGGTVVEGTAGNTGIGLAH
LCNARGYRCVIVIPETQSAEKIDLLRSLGAEVRTVPAVPYRDPNNYVKLSGRIAEEIPGAVWANQFDNRANRQAHADTTG
PEIWQQCEGRLDGWVAATGTGGTYAGVALYLKQQSDAVRCVLADPHGSALYSWASNGELASEGSSVTEGIGNSRITANLE
GAPVDEAIRIDDQTAIDVLYDLLWHEGLFLGGSVGINVAAAVELARRLGPGHRIVTVLCDGGDRYRSRIWNQEWLQSRGL
RQPERQQLGSVA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=41.1585365853659, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=41.1585365853659, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=41.1585365853659, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI2367138, Length=301, Percent_Identity=36.2126245847176, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788754, Length=322, Percent_Identity=36.3354037267081, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=40, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=37.248322147651, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=37.248322147651, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=38.1578947368421, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17534315, Length=324, Percent_Identity=35.1851851851852, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17561720, Length=300, Percent_Identity=37, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=33.1269349845201, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=33.6448598130841, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71996324, Length=351, Percent_Identity=25.6410256410256, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17539800, Length=343, Percent_Identity=23.9067055393586, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=42.1538461538462, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6321594, Length=326, Percent_Identity=37.1165644171779, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24643623, Length=325, Percent_Identity=36.9230769230769, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129101, Length=325, Percent_Identity=36.9230769230769, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 35341; Mature: 35210

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGITRGFVGAVGNTPLIRLEHLSECTGCEILGKAEFMNPGGSVKDRAALGILLAAEASGD
CCCCCCCHHCCCCCCEEEEHHHCCCCCCEEECCCEECCCCCCCCCHHHEEEEEEECCCCC
LKAGGTVVEGTAGNTGIGLAHLCNARGYRCVIVIPETQSAEKIDLLRSLGAEVRTVPAVP
CCCCCEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCC
YRDPNNYVKLSGRIAEEIPGAVWANQFDNRANRQAHADTTGPEIWQQCEGRLDGWVAATG
CCCCCCEEEECCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
TGGTYAGVALYLKQQSDAVRCVLADPHGSALYSWASNGELASEGSSVTEGIGNSRITANL
CCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEEEC
EGAPVDEAIRIDDQTAIDVLYDLLWHEGLFLGGSVGINVAAAVELARRLGPGHRIVTVLC
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGGDRYRSRIWNQEWLQSRGLRQPERQQLGSVA
CCCHHHHHHCCCHHHHHHCCCCCHHHHHHCCCC
>Mature Secondary Structure 
GITRGFVGAVGNTPLIRLEHLSECTGCEILGKAEFMNPGGSVKDRAALGILLAAEASGD
CCCCCCHHCCCCCCEEEEHHHCCCCCCEEECCCEECCCCCCCCCHHHEEEEEEECCCCC
LKAGGTVVEGTAGNTGIGLAHLCNARGYRCVIVIPETQSAEKIDLLRSLGAEVRTVPAVP
CCCCCEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCC
YRDPNNYVKLSGRIAEEIPGAVWANQFDNRANRQAHADTTGPEIWQQCEGRLDGWVAATG
CCCCCCEEEECCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEEC
TGGTYAGVALYLKQQSDAVRCVLADPHGSALYSWASNGELASEGSSVTEGIGNSRITANL
CCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHCCCCCEEEEEC
EGAPVDEAIRIDDQTAIDVLYDLLWHEGLFLGGSVGINVAAAVELARRLGPGHRIVTVLC
CCCCCCCEEEECCHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEE
DGGDRYRSRIWNQEWLQSRGLRQPERQQLGSVA
CCCHHHHHHCCCHHHHHHCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]