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The map label for this gene is tpm

Identifier: 147675652

GI number: 147675652

Start: 860419

End: 861075

Strand: Direct

Name: tpm

Synonym: VC0395_A0849

Alternate gene names: 147675652

Gene position: 860419-861075 (Clockwise)

Preceding gene: 147673436

Following gene: 147675201

Centisome position: 28.45

GC content: 49.01

Gene sequence:

>657_bases
ATGCGAGATCCTGAGTTTTGGCATAACAAATGGGCGGCGAACCAGATTGGTTTTCACCTTGAAGACGTGAACCCGCTATT
GATCCGCTTTTGGTCTGATCTTGCCCCTAAACGCAGTGAAAAAGTGCTCGTCCCTTTGTGTGGTAAGAGTGAAGATCTGA
TTTGGCTGGCGAATCAGCATGACAGTGTTCAAGGGGTTGAACTGAGTCAAATCGCGGTACGTTCTTTCTTTGCCGAGCAT
TTCTATACCCCGACAGTGACCCGACTCAATGCGCAACATGAACTATATCAGTTTGATGAGCTTACGCTTTTTACCGGAGA
TTTCTTCACAGCTCCTGTTGAATCGGTGGACTTAGTTTATGATCGTGCGGCGCTAGTGGCATTGCCGGAAGAGATGCGCA
CAGAGTACGCGCAGCGCGTGTTGCAACTGCTTAAACCGGGTGGGCGCATTTTGCTGGTCAGTATGGATTATGTGCAAACT
GAGTTGTCAGGGCCGCCATTTTCGGTTCCTGAAGCGGAAATTCGAACCTTGTTTATGGGATGTGAGGTGCGCAGAGTTTA
CCAAGATACGAGCATAGATCCGCATCTGAATAAGCGCACACAAGCGGGCTTAAGCCGCTTTGCCGAAGAAGTTTGGGTGA
TTGAGAAAAGCGAGTGA

Upstream 100 bases:

>100_bases
GAAATGTAACCGTCGAACAGATGGGGAGGGACAAATTCGTGCTACCGCGGGAGCAGAAGATCCGCTACTCTTGGCGGCAG
CAAATGAAAAGGAGTAGAAG

Downstream 100 bases:

>100_bases
CTCTGACTCTTTGAACGCCACTAAGTAGAAATGAAAAAAGCGCGCTGAATGAGCGCGCTTTCTGATAGTGCTGATAAAGA
TAAAGAGCTGAATTAGTAAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRTEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE

Sequences:

>Translated_218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRTEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
>Mature_218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRTEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=189, Percent_Identity=32.2751322751323, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_VIBC3 (A5F1V4)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F1V4
- SMR:   A5F1V4
- STRING:   A5F1V4
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0849
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   PPFAVSP
- ProtClustDB:   PRK13255
- BioCyc:   VCHO345073:VC0395_A0849-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 25144; Mature: 25144

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: BINDING 11-11 BINDING 46-46 BINDING 67-67 BINDING 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQH
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCC
DSVQGVELSQIAVRSFFAEHFYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVY
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCEEEEECCCCCCCHHHHHHHH
DRAALVALPEEMRTEYAQRVLQLLKPGGRILLVSMDYVQTELSGPPFSVPEAEIRTLFMG
HHHHEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCHHHHHHHHHC
CEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCC
>Mature Secondary Structure
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQH
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCC
DSVQGVELSQIAVRSFFAEHFYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVY
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHCCEEEEECCCCCCCHHHHHHHH
DRAALVALPEEMRTEYAQRVLQLLKPGGRILLVSMDYVQTELSGPPFSVPEAEIRTLFMG
HHHHEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCHHHHHHHHHC
CEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA