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The map label for this gene is epsC

Identifier: 147675412

GI number: 147675412

Start: 2461112

End: 2462029

Strand: Reverse

Name: epsC

Synonym: VC0395_A2307

Alternate gene names: 147675412

Gene position: 2462029-2461112 (Counterclockwise)

Preceding gene: 147675114

Following gene: 147674158

Centisome position: 81.41

GC content: 49.78

Gene sequence:

>918_bases
ATGGAATTTAAACAACTTCCTCCGTTGGCAGCGTGGCCGCGTTTATTGAGCCAGAATACGCTGCGGTGGCAAAAGCCGAT
CAGCGAAGGATTAACGCTACTGTTATTAGTTGCTTCGGCGTGGACGCTGGGCAAGATGGTGTGGGTCGTCTCGGCTGAAC
AAACACCAGTGCCGACTTGGAGCCCCACGTTATCAGGGCTTAAGGCCGAACGTCAGCCACTCGATATCAGCGTATTGCAA
AAAGGTGAGCTGTTTGGTGTGTTTACTGAGCCGAAAGAAGCTCCGGTTGTGGAGCAACCTGTGGTGGTGGATGCTCCGAA
AACGCGCTTGAGCCTTGTGCTGTCTGGTGTGGTGGCGAGTAATGATGCGCAAAAAAGTTTGGCTGTTATCGCCAATCGTG
GTGTGCAAGCGACGTATGGCATTAATGAAGTGATTGAAGGGACTCAGGCCAAGCTAAAAGCCGTGATGCCGGATCGGGTC
ATCATCAGCAACTCCGGGCGTGATGAAACCTTGATGCTTGAAGGGTTAGACTACACCGCGCCTGCGACGGCTTCGGTATC
CAACCCTCCGCGTCCACGACCCAATCAACCTAATGCTGTGCCGCAGTTTGAGGATAAAGTGGATGCAATTCGTGAAGCAA
TCGCACGAAATCCGCAGGAAATTTTTCAATATGTGCGCCTATCTCAGGTAAAACGCGATGACAAAGTACTCGGCTATCGC
GTCAGTCCCGGTAAAGATCCGGTACTGTTTGAATCAATAGGTTTACAAGATGGCGATATGGCAGTGGCACTGAATGGCCT
AGATCTGACCGATCCTAATGTAATGAACACGCTATTTCAGTCGATGAATGAGATGACTGAAATGAGTCTGACCGTTGAGC
GTGATGGTCAACAACATGATGTATATATTCAATTTTAA

Upstream 100 bases:

>100_bases
TATATTGCGATGCCTGCATAAAGTATTGAAAAACATCTGTACAAACAGATTTGCGCAATATGAAGCGTAAAAAGTACAGA
AAGGAATAACGTGGAAATTT

Downstream 100 bases:

>100_bases
CGCTAAGGCGAGTAACGACGCCTTAGTGAGGCAAGGGAGTTCCCAGTGAAATATTGGCTGAAAAAAAGTTCATGGCTGTT
GGCGGGCAGTTTGCTGTCTA

Product: general secretion pathway protein C

Products: NA

Alternate protein names: Cholera toxin secretion protein epsC

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASAWTLGKMVWVVSAEQTPVPTWSPTLSGLKAERQPLDISVLQ
KGELFGVFTEPKEAPVVEQPVVVDAPKTRLSLVLSGVVASNDAQKSLAVIANRGVQATYGINEVIEGTQAKLKAVMPDRV
IISNSGRDETLMLEGLDYTAPATASVSNPPRPRPNQPNAVPQFEDKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYR
VSPGKDPVLFESIGLQDGDMAVALNGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHDVYIQF

Sequences:

>Translated_305_residues
MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASAWTLGKMVWVVSAEQTPVPTWSPTLSGLKAERQPLDISVLQ
KGELFGVFTEPKEAPVVEQPVVVDAPKTRLSLVLSGVVASNDAQKSLAVIANRGVQATYGINEVIEGTQAKLKAVMPDRV
IISNSGRDETLMLEGLDYTAPATASVSNPPRPRPNQPNAVPQFEDKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYR
VSPGKDPVLFESIGLQDGDMAVALNGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHDVYIQF
>Mature_305_residues
MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASAWTLGKMVWVVSAEQTPVPTWSPTLSGLKAERQPLDISVLQ
KGELFGVFTEPKEAPVVEQPVVVDAPKTRLSLVLSGVVASNDAQKSLAVIANRGVQATYGINEVIEGTQAKLKAVMPDRV
IISNSGRDETLMLEGLDYTAPATASVSNPPRPRPNQPNAVPQFEDKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYR
VSPGKDPVLFESIGLQDGDMAVALNGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHDVYIQF

Specific function: Required for secretion of cholera toxin through the outer membrane

COG id: COG3031

COG function: function code U; Type II secretory pathway, component PulC

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP C family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSPC_VIBCH (P45777)

Other databases:

- EMBL:   L33796
- EMBL:   AE003852
- PIR:   G82041
- RefSeq:   NP_232360.1
- PDB:   2I4S
- PDB:   2I6V
- PDBsum:   2I4S
- PDBsum:   2I6V
- ProteinModelPortal:   P45777
- SMR:   P45777
- GeneID:   2614897
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2734
- TIGR:   VC_2734
- HOGENOM:   HBG511585
- OMA:   APKTRLN
- ProtClustDB:   CLSK874904
- InterPro:   IPR001639
- PRINTS:   PR00810
- TIGRFAMs:   TIGR01713

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 33585; Mature: 33585

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01141 T2SP_C

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1b5ab964)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASAWTLGKMVWVVSAEQTPVPTW
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCC
SPTLSGLKAERQPLDISVLQKGELFGVFTEPKEAPVVEQPVVVDAPKTRLSLVLSGVVAS
CCHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHC
NDAQKSLAVIANRGVQATYGINEVIEGTQAKLKAVMPDRVIISNSGRDETLMLEGLDYTA
CCHHHHHHHHHCCCCEEECCHHHHHCCHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCC
PATASVSNPPRPRPNQPNAVPQFEDKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEE
VSPGKDPVLFESIGLQDGDMAVALNGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHD
ECCCCCCEEEHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCC
VYIQF
EEEEH
>Mature Secondary Structure
MEFKQLPPLAAWPRLLSQNTLRWQKPISEGLTLLLLVASAWTLGKMVWVVSAEQTPVPTW
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCC
SPTLSGLKAERQPLDISVLQKGELFGVFTEPKEAPVVEQPVVVDAPKTRLSLVLSGVVAS
CCHHHCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHC
NDAQKSLAVIANRGVQATYGINEVIEGTQAKLKAVMPDRVIISNSGRDETLMLEGLDYTA
CCHHHHHHHHHCCCCEEECCHHHHHCCHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCC
PATASVSNPPRPRPNQPNAVPQFEDKVDAIREAIARNPQEIFQYVRLSQVKRDDKVLGYR
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEE
VSPGKDPVLFESIGLQDGDMAVALNGLDLTDPNVMNTLFQSMNEMTEMSLTVERDGQQHD
ECCCCCCEEEHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCCC
VYIQF
EEEEH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301