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The map label for this gene is fadR

Identifier: 147675341

GI number: 147675341

Start: 1601170

End: 1602009

Strand: Reverse

Name: fadR

Synonym: VC0395_A1490

Alternate gene names: 147675341

Gene position: 1602009-1601170 (Counterclockwise)

Preceding gene: 147673704

Following gene: 147674459

Centisome position: 52.98

GC content: 44.88

Gene sequence:

>840_bases
ATGGTCATTAAGGCAAAAAGCCCAGCCGGTTTCGCTGAGAAGTATATTATTGAAAGTATTTGGAACGGCCGCTTTCCGCC
AGGTTCCATCTTACCTGCAGAGCGTGAGCTTTCTGAATTGATCGGTGTTACGCGTACCACACTACGTGAGGTGTTACAGC
GTTTAGCGCGTGATGGTTGGCTCACGATTCAACACGGTAAACCCACCAAGGTGAATCAGTTTATGGAAACATCAGGTTTG
CATATTCTTGATACCTTGATGACTCTTGATGCAGAGAATGCCACCAGCATTGTTGAAGACTTACTAGCTGCAAGAACCAA
TATCAGCCCCATTTTCATGCGTTACGCTTTTAAGCTAAATAAAGAGAGCGCAGAGCGGATCATGATCAATGTGATTGAGT
CTTGTGAAGCCTTGGTTAACGCCCCTTCTTGGGATGCGTTTATCGCAGCTTCTCCCTATGCGGAAAAAATCCAGCAGCAC
GTGAAAGAAGACAGCGAAAAAGATGAGCTCAAAAGGCAGGAAATCTTGATCGCGAAAACATTTAATTTCTACGATTACAT
GTTATTCCAGCGTCTCGCTTTCCATTCTGGTAACCAGATTTACGGTTTGATCTTTAACGGGTTGAAAAAGCTGTATGACC
GTGTGGGAAGTTACTATTTTTCCAATCCTCAAGCGCGTGAATTGGCCATGGAATTCTACCGTCAGTTGTTAGCTGTGTGC
CAAAGCGGCGAGCGTGAGCATTTGCCTCAGGTTATTCGTCAGTATGGTATTGCTAGCGGACACATCTGGAATCAGATGAA
AATGACGCTGCCGTCCAATTTTACTGAAGACGATTGCTAA

Upstream 100 bases:

>100_bases
TTGTGACAAGTTTATCGATGCTTGGTTTTCGACGTACACCAACTAGTGGTATGATGAGTGCCATTCGACCCAAATAAAAC
AAGTATTGGATTAGTCATTA

Downstream 100 bases:

>100_bases
TCTAGCACTGTTCGTTTTCGTTAAAGAAGCCCGCATTGTCACGCGGGCTTTTTACTATTGAAATTAATCCCAATCCCTTG
AGTTTAGTGATGATGGTTAT

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVIKAKSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQH
VKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVC
QSGEREHLPQVIRQYGIASGHIWNQMKMTLPSNFTEDDC

Sequences:

>Translated_279_residues
MVIKAKSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQH
VKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVC
QSGEREHLPQVIRQYGIASGHIWNQMKMTLPSNFTEDDC
>Mature_279_residues
MVIKAKSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLNKESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQH
VKEDSEKDELKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVC
QSGEREHLPQVIRQYGIASGHIWNQMKMTLPSNFTEDDC

Specific function: Multifunctional regulator of fatty acid metabolism

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787436, Length=274, Percent_Identity=52.1897810218978, Blast_Score=284, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADR_VIBC3 (A5F6Z2)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F6Z2
- SMR:   A5F6Z2
- STRING:   A5F6Z2
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1490
- eggNOG:   COG2186
- HOGENOM:   HBG296777
- OMA:   IVRSIWE
- ProtClustDB:   PRK04984
- BioCyc:   VCHO345073:VC0395_A1490-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00696
- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00345
- TIGRFAMs:   TIGR02812

Pfam domain/function: PF07840 FadR_C; PF00392 GntR; SSF48008 FadR_C

EC number: NA

Molecular weight: Translated: 31998; Mature: 31998

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKAKSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLN
EEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHC
KESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKT
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVC
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QSGEREHLPQVIRQYGIASGHIWNQMKMTLPSNFTEDDC
CCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVIKAKSPAGFAEKYIIESIWNGRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNQFMETSGLHILDTLMTLDAENATSIVEDLLAARTNISPIFMRYAFKLN
EEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHC
KESAERIMINVIESCEALVNAPSWDAFIAASPYAEKIQQHVKEDSEKDELKRQEILIAKT
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FNFYDYMLFQRLAFHSGNQIYGLIFNGLKKLYDRVGSYYFSNPQARELAMEFYRQLLAVC
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QSGEREHLPQVIRQYGIASGHIWNQMKMTLPSNFTEDDC
CCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA