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The map label for this gene is uppS [H]

Identifier: 147675134

GI number: 147675134

Start: 1965386

End: 1966156

Strand: Reverse

Name: uppS [H]

Synonym: VC0395_A1847

Alternate gene names: 147675134

Gene position: 1966156-1965386 (Counterclockwise)

Preceding gene: 147673161

Following gene: 147674661

Centisome position: 65.02

GC content: 46.17

Gene sequence:

>771_bases
TTGTTCGTTGTGTTTCTTATGCAAAATCTATCTCTTTCCCAAGATGTATTGCCTAAACATATTGCCGTCATTATGGATGG
TAATGGTCGTTGGGCGAAAGCGCAGGGAAAACCGCGTGTTTTCGGCCATAAAAATGGTGTGGCTGCGGTACGAAAAACCA
TCTCTACTTCTGCTCGCCTTGGCATTAAAGCCGTAACTCTGTTTGCTTTTAGCAGCGAGAACTGGCGTCGTCCGGAAGAA
GAAGTGGGCGTGTTGATGGAACTTTTTATGACGGTTCTTTCAACCGAAATTAAGAAATTGCATAAAAACAATCTGCGTTT
GCGAGTGATCGGTGATAAAAGCCGCTTTAGTGAGCGTCTGCAAACGAAAATCGCGCAAGCGGAGCAGTTAACCGCCAGCA
ATACCGGCATGGTGGTCAACATCGCTGCGAACTACGGTGGACAGTGGGATATCTTGCAAGCTACTCAAGCATTGGCTGAA
AAGGTTACCCAAGGTGAACTGCAACCGTCGGACATCGATGAAGACGTATTTAAGCAGCATTTGACTATGGCTGATCTGCC
GGATGTGGATTTGTTGATCCGCACCAGTGGAGAGTGCCGCATTAGTAATTTTATGCTTTGGCAACTTGCCTATGCAGAAA
TGTATTTCACTCCAGTCTTCTGGCCTGAGTTCGATGAAAACTGCCTGATTGAAGCAGTGACTTGGTTTGTTAATCGTGAG
CGCCGTTTTGGCTGTACTGGTGAACAAGTCAAGGCATTGATGGAAAACTGA

Upstream 100 bases:

>100_bases
AAAGAAAAAGAGTTGATGGAAGTTTAATCCACTGACTTGGTGAACAAAACGCTGTGCTCGCAGCACAGCGTTTTTTTATG
CTACTCTTGCGCCTCTTTGA

Downstream 100 bases:

>100_bases
ATATAGGACTTCTCAATTTGAAGCAGCGAATCATTACAGCGCTTATTCTGGCGCCTTTGGTGATCCTTGGCATCCTTTAT
CTGCCTTTTGCTTGGTTTAT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFVVFLMQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARLGIKAVTLFAFSSENWRRPEE
EVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERLQTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAE
KVTQGELQPSDIDEDVFKQHLTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRE
RRFGCTGEQVKALMEN

Sequences:

>Translated_256_residues
MFVVFLMQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARLGIKAVTLFAFSSENWRRPEE
EVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERLQTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAE
KVTQGELQPSDIDEDVFKQHLTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRE
RRFGCTGEQVKALMEN
>Mature_256_residues
MFVVFLMQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARLGIKAVTLFAFSSENWRRPEE
EVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERLQTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAE
KVTQGELQPSDIDEDVFKQHLTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRE
RRFGCTGEQVKALMEN

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=40.8071748878924, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=40.8071748878924, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=61.4035087719298, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71993029, Length=223, Percent_Identity=34.0807174887892, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=33.6448598130841, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=33.1797235023041, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI18857969, Length=211, Percent_Identity=35.5450236966825, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29048; Mature: 29048

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVFLMQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARL
CEEEEEECCCCCCHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GIKAVTLFAFSSENWRRPEEEVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERL
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
QTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAEKVTQGELQPSDIDEDVFKQH
HHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRE
CCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
RRFGCTGEQVKALMEN
CCCCCCHHHHHHHHCC
>Mature Secondary Structure
MFVVFLMQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARL
CEEEEEECCCCCCHHHCCCEEEEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHC
GIKAVTLFAFSSENWRRPEEEVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERL
CEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHH
QTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAEKVTQGELQPSDIDEDVFKQH
HHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRE
CCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCC
RRFGCTGEQVKALMEN
CCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]