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The map label for this gene is pyrH

Identifier: 147674990

GI number: 147674990

Start: 1966841

End: 1967572

Strand: Reverse

Name: pyrH

Synonym: VC0395_A1849

Alternate gene names: 147674990

Gene position: 1967572-1966841 (Counterclockwise)

Preceding gene: 147675519

Following gene: 147673161

Centisome position: 65.06

GC content: 49.04

Gene sequence:

>732_bases
ATGACAACGAACCCTAAACCAGCTTATCAACGTATTCTGTTAAAACTAAGTGGTGAAGCGCTACAAGGCTCTGAAGGTTT
TGGTATTGATCCAACGGTACTTGATCGTATGGCTCAAGAAGTAAAAGAACTGGTTGAGCTGGGTGTTCAAGTGGGCGTTG
TGATTGGTGGCGGCAACCTATTCCGTGGTGCTGGCCTTGCCAAAGCGGGTATGAACCGTGTTGTTGGGGATCATATGGGC
ATGCTTGCCACGGTAATGAATGGTTTGGCAATGCGTGATGCCCTGCATCGTGCTTACGTCAATGCACGTCTGATGTCTGC
TATCCCACTAAATGGTGTGTGTGACGATTACAGCTGGTCTGATGCGATTCGCGAATTGCGCCAAGGCCGAGTGGTGATTT
TTGCTGCGGGTACAGGCAATCCTTTCTTTACTACGGATTCGGCTGCGTGTCTGCGTGGTATTGAAATTGAAGCTGATGTC
GTTCTCAAAGCGACCAAAGTAGATGGTGTTTACAGCGCTGACCCGGTAGCCAACCCGGATGCACAACTGTATGATAAGCT
GGCTTACAACGATGTGCTTGAGAAAGAACTGAAAGTGATGGATTTGGCGGCGTTTACTCTGGCTCGTGACCATAAAATGC
CAATTCGTGTCTTCAACATGAATAAGCCAGGCGCACTTCGTCGTGTCGTTATGGGTGAAGCTGAAGGTACGCTGATCAGC
GACGTGCAGTGA

Upstream 100 bases:

>100_bases
AAAGCGTCGACTCGATTAACCGTGATGAATGGATTTTGGCCTAGCACTCAAATCTATCCATGACTGTTAATCCTCAACTC
TCTTTGGAAGGTAAACTCCC

Downstream 100 bases:

>100_bases
TCCGTCTGCGAACGAAACGCTCTCGAAACGAAAACAAGAATTAAGGTGATATTGTGATTAATGAGATCAAAAAAGATGCG
CAAGAGCGTATGGAGAAAAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMG
MLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADV
VLKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLIS
DVQ

Sequences:

>Translated_243_residues
MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMG
MLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADV
VLKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLIS
DVQ
>Mature_242_residues
TTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAKAGMNRVVGDHMGM
LATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWSDAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVV
LKATKVDGVYSADPVANPDAQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLISD
VQ

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=241, Percent_Identity=85.0622406639004, Blast_Score=432, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_VIBC3 (A5F619)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F619
- SMR:   A5F619
- STRING:   A5F619
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1849
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   VCHO345073:VC0395_A1849-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26197; Mature: 26065

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 58-58 BINDING 62-62 BINDING 77-77 BINDING 165-165 BINDING 171-171 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNL
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
FRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVANPD
HHHHHHHCCCEEEEEECCCCCCEECCHHHHHHCCEECCEEEEEEEECCCCCCCCCCCCCC
AQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCEEC
DVQ
CCC
>Mature Secondary Structure 
TTNPKPAYQRILLKLSGEALQGSEGFGIDPTVLDRMAQEVKELVELGVQVGVVIGGGNL
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
FRGAGLAKAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDDYSWS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DAIRELRQGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVANPD
HHHHHHHCCCEEEEEECCCCCCEECCHHHHHHCCEECCEEEEEEEECCCCCCCCCCCCCC
AQLYDKLAYNDVLEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGEAEGTLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCEEC
DVQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA