Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 147674970

GI number: 147674970

Start: 2196678

End: 2197355

Strand: Reverse

Name: rnc

Synonym: VC0395_A2039

Alternate gene names: 147674970

Gene position: 2197355-2196678 (Counterclockwise)

Preceding gene: 147675126

Following gene: 147674346

Centisome position: 72.66

GC content: 49.56

Gene sequence:

>678_bases
ATGACACCTCCAATGAATAAATTAACAAGTAAGCTCGGTTATACCTTTAAGGAGACTGAGCTGCTTAATCTGGCGCTGAC
ACACCGCAGCGCCAATGGTAAGCACAATGAACGTCTTGAGTTTCTGGGCGATTCAATTTTAAGTTTTGTCATTGCTGACG
AGCTCTATCGCCGCTTCCCGAAAGTGAATGAGGGAGATATGAGCCGCATGCGTGCCACCTTAGTGCGTGGTAACACGTTG
GCGGAGCTGGGTCGTGAATTCGATCTGGGAGATTACTTAAAATTAGGTCCAGGTGAGTTGAAAAGCGGTGGTTTTCGCCG
TGACTCGATTCTGGCCGATGCCGTAGAAGCCATCATTGGTGCGATCTACCTCGATAGTGATTTAGAAACCGCGCGCCGCA
TTGTGCTGGAGTGGTATCAATGTCGCCTTGAGGAGATCAAACCGGGCGCATCACAAAAAGACCCGAAAACTCGTTTACAA
GAGTTTTTGCAAGGCAGAAGAAAACCGCTGCCCGTCTACACTGTGACTAATATTAAAGGTGAAGCGCACAACCAAGAATT
TACGGTTGCGTGTGAAGTTGCAGGTATGGACACGCCTGTGATCGGTAAAGGCACCAGCCGCCGCAAGGCAGAGCAAGCGG
CTGCAGAAACGGCTCTGGAGCAATTAACTCATGGCTGA

Upstream 100 bases:

>100_bases
GAAGACAGCGTACTTCCACGCTGGATTCCTACCGGAGTACGATTCAATCGTGTTGGTGGGATCCACTAAGCCGGCATGAG
CTGGCAATAACGTTGAGATT

Downstream 100 bases:

>100_bases
TCAAGAATTTGATATCGATGCATACTTTGCTTCTCGCAGCGAAGGTCAAACGGCGACATCGACACCAGAGGACCAACACT
GCGGCTTTGTCGCAATTGTC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFPKVNEGDMSRMRATLVRGNTL
AELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDLETARRIVLEWYQCRLEEIKPGASQKDPKTRLQ
EFLQGRRKPLPVYTVTNIKGEAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTHG

Sequences:

>Translated_225_residues
MTPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFPKVNEGDMSRMRATLVRGNTL
AELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDLETARRIVLEWYQCRLEEIKPGASQKDPKTRLQ
EFLQGRRKPLPVYTVTNIKGEAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTHG
>Mature_224_residues
TPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFPKVNEGDMSRMRATLVRGNTLA
ELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDLETARRIVLEWYQCRLEEIKPGASQKDPKTRLQE
FLQGRRKPLPVYTVTNIKGEAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTHG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=32.1888412017167, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=32.1888412017167, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1788920, Length=218, Percent_Identity=70.6422018348624, Blast_Score=318, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17506883, Length=229, Percent_Identity=31.8777292576419, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193202651, Length=226, Percent_Identity=32.3008849557522, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=30.1310043668122, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_VIBC3 (A5F5H8)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F5H8
- SMR:   A5F5H8
- STRING:   A5F5H8
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A2039
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   VCHO345073:VC0395_A2039-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25140; Mature: 25009

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFP
CCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
KVNEGDMSRMRATLVRGNTLAELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AIYLDSDLETARRIVLEWYQCRLEEIKPGASQKDPKTRLQEFLQGRRKPLPVYTVTNIKG
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTHG
CCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFP
CCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
KVNEGDMSRMRATLVRGNTLAELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIG
CCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AIYLDSDLETARRIVLEWYQCRLEEIKPGASQKDPKTRLQEFLQGRRKPLPVYTVTNIKG
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
EAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTHG
CCCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA