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The map label for this gene is serS

Identifier: 147674801

GI number: 147674801

Start: 669867

End: 671174

Strand: Direct

Name: serS

Synonym: VC0395_A0628

Alternate gene names: 147674801

Gene position: 669867-671174 (Clockwise)

Preceding gene: 147673167

Following gene: 147673516

Centisome position: 22.15

GC content: 49.85

Gene sequence:

>1308_bases
ATGCTGGATTCTAAATTACTTCGTACTGAGCTGGACGAAACAGCTGCAAAATTGGCACGTCGCGGTTTTAAACTCGACGT
GGAGACTATCCGTACTCTTGAAGAACAACGTAAGTCCATTCAAGTAGAAGTTGAGAATTTACAATCCACGCGTAACTCCA
TCTCCAAGCAAATCGGTCAACTGATGGCGTCTGGCGACAAAGCGGGCGCAGAAGCGGTTAAGCAACAAATCGGCACCTTG
GGTGACGATCTGGATGCGAAAAAAGTGGAATTGGATGCGGTTATGGCGCAATTGGATGCGATCACCCAAACCGTGCCTAA
CATTCCAGACGATGCAGTGCCAAACGGTAAAGACGACAGCGAAAACGTAGAAGTGTCTCGTTGGGGCACCCCAAAAACGT
ATGATTTTGAAGTGAAAGATCATGTGGATTTGGGTGAAATGGGCGACGGTCTGGATTTCGCAAGCGCAACCAAGATCACG
GGTGCGCGTTTTGTGGTGATGAAAGGTCAATTTGCTCGTTTGCACCGTGCTATCGCACAGTTCATGTTGGATCTGCACAC
CGATCAACACGGCTACACTGAGCTGTATGTGCCTTATCTAGTGAACGCTGAAACGCTGTTCGGTACAGGCCAATTACCAA
AATTCGGTCAAGATCTGTTCCACACTGAGCCTCTGACTGAGAAAGCCAGTGATGAAGAGCCACGCCGTCTATCACTGATC
CCAACCGCAGAAGTGCCAGTGACCAACTTAGTGCGCGACACCATTTTGGATGAAGCTGAACTGCCTCTGAAAATGACCGC
ACACACGCCATGCTTCCGTTCTGAAGCCGGTTCTTACGGTCGTGATACTCGTGGTCTGATCCGTATGCACCAGTTTGATA
AAGTGGAACTGGTACAAATCACTCGCCCTGAAGATTCTATGGCGGCATTGGAAGAGTTGACTGGCCATGCAGAAAAAGTT
CTGCAACTGCTGGAGCTGCCTTACCGCAAAGTGATTCTGTGTACGGGCGACATGGGCTTTGGCTCGTGCAAAACTTACGA
CTTGGAAGTTTGGGTTCCAGCGCAGAAGACGTACCGTGAAATCTCTTCTTGTTCAAACATGTGGGATTTCCAAGCGCGTC
GTATGCAAGCGCGTTTCCGCCGCAAAGGTGAGAAGAAACCTGAGTTGGTGCACACGCTGAACGGCTCTGGTCTGGCGGTG
GGTCGTACCATGGTCGCGATTTTGGAAAACTACCAAGAAGCCGATGGTCGCATTGCGATTCCTGCGGTACTGCAAAAGTA
CATGGGCGGTTTAACCCATATCGGTTAA

Upstream 100 bases:

>100_bases
CTTTTGGTTATCTTTGGCAGGGTAAATTTCAATACGCGTGGCTTTGGCTAAAAAGGAAGCACACGCGCTTTCTCGCAACT
CTTAAAGCATAGGATTAGCA

Downstream 100 bases:

>100_bases
TCCCGTTTTCCTTTAAAGGGAAATTAGCGCTCAAAACGTATAAGAATGAAAAAAGCCGACGTGATGTCGGCTTTTTTATG
CTTGTCGTTTGTTGCGCAGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQLMASGDKAGAEAVKQQIGTL
GDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDSENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKIT
GARFVVMKGQFARLHRAIAQFMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITRPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENYQEADGRIAIPAVLQKYMGGLTHIG

Sequences:

>Translated_435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQLMASGDKAGAEAVKQQIGTL
GDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDSENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKIT
GARFVVMKGQFARLHRAIAQFMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITRPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENYQEADGRIAIPAVLQKYMGGLTHIG
>Mature_435_residues
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQLMASGDKAGAEAVKQQIGTL
GDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDSENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKIT
GARFVVMKGQFARLHRAIAQFMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITRPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENYQEADGRIAIPAVLQKYMGGLTHIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=436, Percent_Identity=33.0275229357798, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI8923421, Length=413, Percent_Identity=26.634382566586, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI225579074, Length=415, Percent_Identity=26.5060240963855, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=71.0344827586207, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=441, Percent_Identity=31.5192743764172, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=371, Percent_Identity=26.1455525606469, Blast_Score=135, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321799, Length=404, Percent_Identity=30.9405940594059, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320226, Length=410, Percent_Identity=30.4878048780488, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24581334, Length=434, Percent_Identity=32.9493087557604, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737985, Length=345, Percent_Identity=31.304347826087, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_VIBC3 (A5F2H1)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F2H1
- SMR:   A5F2H1
- STRING:   A5F2H1
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A0628
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   VCHO345073:VC0395_A0628-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48571; Mature: 48571

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 296-296 BINDING 396-396

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMASGDKAGAEAVKQQIGTLGDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDS
HHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKITGARFVVMKGQFARLHRAIAQ
CCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHH
FMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
HHHHHCCCCCCCEEEEEEEEECCHHEECCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEC
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TRPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENYQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEH
PAVLQKYMGGLTHIG
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMASGDKAGAEAVKQQIGTLGDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDS
HHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKITGARFVVMKGQFARLHRAIAQ
CCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCHHCCCCCEEEEEECCHHHHHHHHHHH
FMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLI
HHHHHCCCCCCCEEEEEEEEECCHHEECCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEC
PTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TRPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENYQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEH
PAVLQKYMGGLTHIG
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA