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The map label for this gene is parC [H]

Identifier: 147674657

GI number: 147674657

Start: 2156492

End: 2158777

Strand: Reverse

Name: parC [H]

Synonym: VC0395_A2007

Alternate gene names: 147674657

Gene position: 2158777-2156492 (Counterclockwise)

Preceding gene: 147674220

Following gene: 147675576

Centisome position: 71.39

GC content: 52.1

Gene sequence:

>2286_bases
ATGTCTACTGAAATCAGCTTTGATGGCGTTGAACAACTGCCGCTGCGCAAATTTACTGAAGACGCTTATCTCAACTATTC
GATGTACGTCATCATGGACCGTGCCTTGCCCTACATTGGCGATGGCTTAAAACCGGTTCAGCGACGCATCATCTACGCGA
TGTCTGAGTTGGGTCTCTCGGCATCGGCCAAATACAAAAAATCAGCACGTACCGTGGGTGACGTACTGGGTAAATACCAT
CCGCATGGCGATTCGGCCTGTTACGAAGCCATGGTGTTGATGGCGCAGCCATTCTCTTATCGCTATCCGTTAGTGGATGG
TCAAGGTAACTGGGGGGCACCGGACGATCCGAAATCGTTCGCGGCCATGCGTTATACCGAAGCCAAACTGTCAAAGTTTG
CCGAGATTCTGCTTAGCGAATTAGGCCAAGGCACCGTAGATTGGCAACCAAACTTTGACGGCACCATGCAAGAGCCGAAA
ATGTTGCCAGCGCGTCTGCCGCACATTCTGCTCAATGGTGTCACCGGCATCGCGGTAGGTATGGCCACCGACATTCCACC
GCATAACGTGCGTGAAGTGGCGGATGCGACGATTCACCTCATCGATAATCCTAACGCGCCGCTGACCGATTTAATGCAGT
ACGTCAAAGGCCCAGATTTCCCGACCGAAGCGGAAATCATCACCCCAACGGTTGAGCTAGAGAAGATTTACCGCTCTGGC
CGTGGCAGCATCAAAATGCGTGCTGTGTGGTGCAAAGAAGGCTCGGATATCGTGATCACCGCGCTGCCGCATCAAGTCTC
TGGCGCGAAGCTGCTGGAGCAGATCGCCGCGCAGATGCGTGCTAAGAAACTGCCGATGGTGGAAGACTTACGCGATGAAT
CGGATCACGAGAACCCAACGCGTATCGTGATCGTGCCGCGCTCAAATCGCGTCGATTGCGATCTGCTGATGAACCACTTG
TTCGCTTCTACGGATCTGGAAAAGAGCTTCCGCGTTAACCTGAATATGATTGGTCTCGACAATCGTCCTCAGGTCAAAGG
CTTAGTGCAGATCTTGAGCGAGTGGATCTCGTTCCGCCGTGAAACGGTACGCTCACGTTTGCAATATCGCCTCGATAAAG
TGCTGGCTCGTTTGCACATTTTGCAAGGTTTGCTGATTGCTTATCTCAACCTTGATGAAGTGATTGAGATCATCCGCAAC
GAAGACGATCCGAAAGCGGTGTTGATGGCACGCTTTGATCTGACCGATATTCAAGCGGACGCGATCTTAGATACCAAGTT
ACGCCACTTGGCGAAACTGGAAGAGATGAAGATCCGCGGTGAGCAAGATGAGCTAGAAAAAGAGCGTAAAAAACTGGAAG
AGCTACTCGGCTCTGAACGTCGCCTCAATAATCTGCTCAAAAAAGAGATCAAAGCGGATGCCGATAAGTTTGGCGATGAT
CGCCGCTCACCACTGGTCGAACGCGAAGAAGCCAAAGCGCTGACCGAGCGTGATTTGATGCCAAGCGAAGCGATCACCGT
CGTGCTGTCTGAAAAAGGCTGGATCCGTCACGCCAAAGGTCATGATGTGGATTGCCAAAGCTTGAACTACAAAGCAGGCG
ATAATTACCTCACACATGCCTGTGGTAAGAGCAACCAGCAAGCAGTGTTCTTGGGCAGTGATGGCCGCAGTTACTCGCTC
GAATCGCATACGCTGCCATCAGCGCGCGGTCAAGGTGAGCCGATCACGGGGCGTTTGAACGTAGCGGAAGGCACTACGAT
TCGTCAGGTTGTGATGGGCGAGGAAGATCAGCTCTGGTTGGTGGGTTCAGATGCCGGCTACGGCTTTGTGTGTAAAGGCG
ATGACCTACTGTCGAAAAACCGCAGTGGTAAAGCTTTGATCAATCTGCCAGAAAACTCGGAAGTGATGACGCCACAAGTG
ATCGCCGATCTCGATAACGATGAGATTTTAGCCATTACTAACCAAGGGCGAATGTTGCTGTTCCCGATTAAGGATCTGCC
GCAACTGAGCAAAGGTAAAGGTAACAAGATCATCAACATTCCTGCGGCGAAAGCGAAAACCCGTGAGGAAGTGCTGTCCA
ACCTGATGGTGTTGCCACAAGGCGCATCGATTACCCTGTATGCAGGCAAACGTAAGCTAGGCTTGAAGGTGAGCGATCTG
GATAACTTCCGTGGTGAACGCGGCCGTCGTGGCGCTTTGTTGCCCCGTGGCTTGCAACGCGTGACCGCGATTGAGATTGA
AACCTCAGCGGAGCCAGAATCAACCCCGCATTCGGAAGATGAATAG

Upstream 100 bases:

>100_bases
AGCGACCGACGAGATGATGGATATGCTGCTGGGTAAAAAGCGTGCGGATGACCGCCGAGCTTGGCTGCAACGTAACGGCG
ATATGGCAGAGGTGTAACGA

Downstream 100 bases:

>100_bases
ACTAGAGGAGCCATTTGGCTCCTCTTTCTTTACTCTCAACCCCGTGAACTAATACTGATCTTCTGACCAGCCATCGCTGT
CGGACATATCCGGTGCGCCG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MSTEISFDGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSASAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEILLSELGQGTVDWQPNFDGTMQEPK
MLPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSG
RGSIKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDLLMNHL
FASTDLEKSFRVNLNMIGLDNRPQVKGLVQILSEWISFRRETVRSRLQYRLDKVLARLHILQGLLIAYLNLDEVIEIIRN
EDDPKAVLMARFDLTDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDD
RRSPLVEREEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQSLNYKAGDNYLTHACGKSNQQAVFLGSDGRSYSL
ESHTLPSARGQGEPITGRLNVAEGTTIRQVVMGEEDQLWLVGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQV
IADLDNDEILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPAAKAKTREEVLSNLMVLPQGASITLYAGKRKLGLKVSDL
DNFRGERGRRGALLPRGLQRVTAIEIETSAEPESTPHSEDE

Sequences:

>Translated_761_residues
MSTEISFDGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSASAKYKKSARTVGDVLGKYH
PHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEILLSELGQGTVDWQPNFDGTMQEPK
MLPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSG
RGSIKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDLLMNHL
FASTDLEKSFRVNLNMIGLDNRPQVKGLVQILSEWISFRRETVRSRLQYRLDKVLARLHILQGLLIAYLNLDEVIEIIRN
EDDPKAVLMARFDLTDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDD
RRSPLVEREEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQSLNYKAGDNYLTHACGKSNQQAVFLGSDGRSYSL
ESHTLPSARGQGEPITGRLNVAEGTTIRQVVMGEEDQLWLVGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQV
IADLDNDEILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPAAKAKTREEVLSNLMVLPQGASITLYAGKRKLGLKVSDL
DNFRGERGRRGALLPRGLQRVTAIEIETSAEPESTPHSEDE
>Mature_760_residues
STEISFDGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLSASAKYKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTEAKLSKFAEILLSELGQGTVDWQPNFDGTMQEPKM
LPARLPHILLNGVTGIAVGMATDIPPHNVREVADATIHLIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSGR
GSIKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPTRIVIVPRSNRVDCDLLMNHLF
ASTDLEKSFRVNLNMIGLDNRPQVKGLVQILSEWISFRRETVRSRLQYRLDKVLARLHILQGLLIAYLNLDEVIEIIRNE
DDPKAVLMARFDLTDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDDR
RSPLVEREEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQSLNYKAGDNYLTHACGKSNQQAVFLGSDGRSYSLE
SHTLPSARGQGEPITGRLNVAEGTTIRQVVMGEEDQLWLVGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQVI
ADLDNDEILAITNQGRMLLFPIKDLPQLSKGKGNKIINIPAAKAKTREEVLSNLMVLPQGASITLYAGKRKLGLKVSDLD
NFRGERGRRGALLPRGLQRVTAIEIETSAEPESTPHSEDE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=741, Percent_Identity=70.9851551956815, Blast_Score=1108, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=772, Percent_Identity=34.1968911917098, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=397, Percent_Identity=24.9370277078086, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=393, Percent_Identity=22.64631043257, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85009; Mature: 84877

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEISFDGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCC
ASAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFAEILLSELGQGTVDWQPNFDGTMQEPKMLPARLPHILLNGVTGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHEEE
MATDIPPHNVREVADATIHLIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSG
EECCCCCCHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
RIVIVPRSNRVDCDLLMNHLFASTDLEKSFRVNLNMIGLDNRPQVKGLVQILSEWISFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
ETVRSRLQYRLDKVLARLHILQGLLIAYLNLDEVIEIIRNEDDPKAVLMARFDLTDIQAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHH
AILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLVEREEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQSLNYKAGDNYLTHA
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCCHHHHH
CGKSNQQAVFLGSDGRSYSLESHTLPSARGQGEPITGRLNVAEGTTIRQVVMGEEDQLWL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHCCCCCCEEE
VGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQVIADLDNDEILAITNQGRMLL
EECCCCCEEEECCCHHHCCCCCCCEEEECCCCCCCCCCHHHEECCCCCEEEEECCCCEEE
FPIKDLPQLSKGKGNKIINIPAAKAKTREEVLSNLMVLPQGASITLYAGKRKLGLKVSDL
EECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCEEECCC
DNFRGERGRRGALLPRGLQRVTAIEIETSAEPESTPHSEDE
HHCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
STEISFDGVEQLPLRKFTEDAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLS
CCCCCCCCHHHCCHHHHCHHHHCCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCC
ASAKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSF
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHH
AAMRYTEAKLSKFAEILLSELGQGTVDWQPNFDGTMQEPKMLPARLPHILLNGVTGIAVG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHEEE
MATDIPPHNVREVADATIHLIDNPNAPLTDLMQYVKGPDFPTEAEIITPTVELEKIYRSG
EECCCCCCHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCC
RGSIKMRAVWCKEGSDIVITALPHQVSGAKLLEQIAAQMRAKKLPMVEDLRDESDHENPT
CCCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCC
RIVIVPRSNRVDCDLLMNHLFASTDLEKSFRVNLNMIGLDNRPQVKGLVQILSEWISFRR
EEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
ETVRSRLQYRLDKVLARLHILQGLLIAYLNLDEVIEIIRNEDDPKAVLMARFDLTDIQAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCCHH
AILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDD
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
RRSPLVEREEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQSLNYKAGDNYLTHA
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCCHHHHH
CGKSNQQAVFLGSDGRSYSLESHTLPSARGQGEPITGRLNVAEGTTIRQVVMGEEDQLWL
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHCCCCCCEEE
VGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQVIADLDNDEILAITNQGRMLL
EECCCCCEEEECCCHHHCCCCCCCEEEECCCCCCCCCCHHHEECCCCCEEEEECCCCEEE
FPIKDLPQLSKGKGNKIINIPAAKAKTREEVLSNLMVLPQGASITLYAGKRKLGLKVSDL
EECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCEEECCC
DNFRGERGRRGALLPRGLQRVTAIEIETSAEPESTPHSEDE
HHCCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]