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The map label for this gene is fbaA [H]

Identifier: 147674645

GI number: 147674645

Start: 27524

End: 28600

Strand: Direct

Name: fbaA [H]

Synonym: VC0395_A0031

Alternate gene names: 147674645

Gene position: 27524-28600 (Clockwise)

Preceding gene: 147673541

Following gene: 147673216

Centisome position: 0.91

GC content: 47.26

Gene sequence:

>1077_bases
ATGTCTAAGATCTTTGATTTTGTAAAACCTGGTGTTATCTCTGGTGATGACGTACAGAAAGTTTTTGAAGTAGCAAAACA
AAATGGCTTTGCACTTCCAGCAGTAAACTGTGTAGGTACTGACTCTGTAAACGGCGTTCTAGAAGCAGCAGCAAAAGTGA
AAGCGCCTGTTATCGTGCAGTTCTCTAACGGCGGCGCAGCATTCTTTGCTGGTAAAGGTCTGAAACTTGAAGGTCAACAA
GCACAAATTCTGGGCGCGATCGCGGGTGCGAAATACGTTCACACTGTAGCGGAAGCTTACGGCGTTCCAGTGATTCTGCA
CACTGACCACGCAGCGAAAAACCTACTACCTTGGATCGACGGTCTGCTAGACGCGGGTGAAAAACACTTCGCAGAAACCG
GCAAACCACTGTTCTCTTCACACATGATTGACCTGTCTGAAGAGTCTCTGGAAGAGAACATCGAGATCTCTGCAAAATAC
CTAGAGCGCATGGCGAAAATGAACATGACTCTGGAGATCGAACTGGGTTGTACTGGCGGTGAAGAAGATGGCGTTGATAA
CTCAGATATGGATTCTTCTGAGCTGTACACTTCTCCAGAAGACGTGGCATACGCTTACGAGAAACTGAACGCAATCAGCC
ACCGTTTCACTATCGCGGCTTCTTTCGGTAACGTACACGGCGTTTACAAGCCAGGTAACGTGGTTCTGACTCCAACTATC
CTACGTGATTCTCAAAAATACGTTTCTGAGAAGTTTGGTCTGCCAGAAAACTCTCTGAACTTCGTATTCCACGGCGGTTC
AGGTTCTTCTCTGGAAGAAATCCGTGAGTCAATCTCTTACGGCGTGATCAAAATGAACATCGATACTGATACTCAGTGGG
CAACATGGGATGGTATTCGTCAATACGAAGCGAAAAACCATGACTACCTGCAAGGTCAAATCGGTAACCCAACCGGTGAA
GATGCACCGAACAAGAAGTACTACGATCCACGCGTATGGCTACGTGCTGGTCAAGCAGCCATGGTTGCTCGCCTAGAGAA
AGCGTTCTCTGATCTGAACGCGATCGACGTACTGTAA

Upstream 100 bases:

>100_bases
CATTTGTTTGGTAGAATGCCGCGATTGGTGAGCAAACGTTTGCAAGAATTGAAACTTACCGTTTTTATTTTTTAAAACGA
CAGAAAATAGGATTCCATCC

Downstream 100 bases:

>100_bases
TTCGTATTTCGAATTCGATTGAATGAAGAAACCCGCCAAGTGCGGGTTTCTTTTTTATGCAGTCTCAGTGGGATGGGTAG
CAGAGAGATCGAATATTGTT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSKIFDFVKPGVISGDDVQKVFEVAKQNGFALPAVNCVGTDSVNGVLEAAAKVKAPVIVQFSNGGAAFFAGKGLKLEGQQ
AQILGAIAGAKYVHTVAEAYGVPVILHTDHAAKNLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEESLEENIEISAKY
LERMAKMNMTLEIELGCTGGEEDGVDNSDMDSSELYTSPEDVAYAYEKLNAISHRFTIAASFGNVHGVYKPGNVVLTPTI
LRDSQKYVSEKFGLPENSLNFVFHGGSGSSLEEIRESISYGVIKMNIDTDTQWATWDGIRQYEAKNHDYLQGQIGNPTGE
DAPNKKYYDPRVWLRAGQAAMVARLEKAFSDLNAIDVL

Sequences:

>Translated_358_residues
MSKIFDFVKPGVISGDDVQKVFEVAKQNGFALPAVNCVGTDSVNGVLEAAAKVKAPVIVQFSNGGAAFFAGKGLKLEGQQ
AQILGAIAGAKYVHTVAEAYGVPVILHTDHAAKNLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEESLEENIEISAKY
LERMAKMNMTLEIELGCTGGEEDGVDNSDMDSSELYTSPEDVAYAYEKLNAISHRFTIAASFGNVHGVYKPGNVVLTPTI
LRDSQKYVSEKFGLPENSLNFVFHGGSGSSLEEIRESISYGVIKMNIDTDTQWATWDGIRQYEAKNHDYLQGQIGNPTGE
DAPNKKYYDPRVWLRAGQAAMVARLEKAFSDLNAIDVL
>Mature_357_residues
SKIFDFVKPGVISGDDVQKVFEVAKQNGFALPAVNCVGTDSVNGVLEAAAKVKAPVIVQFSNGGAAFFAGKGLKLEGQQA
QILGAIAGAKYVHTVAEAYGVPVILHTDHAAKNLLPWIDGLLDAGEKHFAETGKPLFSSHMIDLSEESLEENIEISAKYL
ERMAKMNMTLEIELGCTGGEEDGVDNSDMDSSELYTSPEDVAYAYEKLNAISHRFTIAASFGNVHGVYKPGNVVLTPTIL
RDSQKYVSEKFGLPENSLNFVFHGGSGSSLEEIRESISYGVIKMNIDTDTQWATWDGIRQYEAKNHDYLQGQIGNPTGED
APNKKYYDPRVWLRAGQAAMVARLEKAFSDLNAIDVL

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=359, Percent_Identity=80.5013927576602, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI87082041, Length=333, Percent_Identity=24.024024024024, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789526, Length=317, Percent_Identity=26.4984227129338, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788072, Length=310, Percent_Identity=24.5161290322581, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=51.5669515669516, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38919; Mature: 38788

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIFDFVKPGVISGDDVQKVFEVAKQNGFALPAVNCVGTDSVNGVLEAAAKVKAPVIVQ
CCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
FSNGGAAFFAGKGLKLEGQQAQILGAIAGAKYVHTVAEAYGVPVILHTDHAAKNLLPWID
ECCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLDAGEKHFAETGKPLFSSHMIDLSEESLEENIEISAKYLERMAKMNMTLEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSDMDSSELYTSPEDVAYAYEKLNAISHRFTIAASFGNVHGVYKPGNVVLTPTI
CCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCEEECCCCEEEEEHH
LRDSQKYVSEKFGLPENSLNFVFHGGSGSSLEEIRESISYGVIKMNIDTDTQWATWDGIR
HHCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
QYEAKNHDYLQGQIGNPTGEDAPNKKYYDPRVWLRAGQAAMVARLEKAFSDLNAIDVL
HHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEECCHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
SKIFDFVKPGVISGDDVQKVFEVAKQNGFALPAVNCVGTDSVNGVLEAAAKVKAPVIVQ
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEE
FSNGGAAFFAGKGLKLEGQQAQILGAIAGAKYVHTVAEAYGVPVILHTDHAAKNLLPWID
ECCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHH
GLLDAGEKHFAETGKPLFSSHMIDLSEESLEENIEISAKYLERMAKMNMTLEIELGCTGG
HHHHCCHHHHHHCCCHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCC
EEDGVDNSDMDSSELYTSPEDVAYAYEKLNAISHRFTIAASFGNVHGVYKPGNVVLTPTI
CCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCEEECCCCEEEEEHH
LRDSQKYVSEKFGLPENSLNFVFHGGSGSSLEEIRESISYGVIKMNIDTDTQWATWDGIR
HHCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
QYEAKNHDYLQGQIGNPTGEDAPNKKYYDPRVWLRAGQAAMVARLEKAFSDLNAIDVL
HHHCCCCCEEECCCCCCCCCCCCCCCCCCCHHEEECCHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]