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The map label for this gene is lpxK [H]

Identifier: 147674626

GI number: 147674626

Start: 1573973

End: 1574983

Strand: Reverse

Name: lpxK [H]

Synonym: VC0395_A1468

Alternate gene names: 147674626

Gene position: 1574983-1573973 (Counterclockwise)

Preceding gene: 147675578

Following gene: 147673931

Centisome position: 52.08

GC content: 51.24

Gene sequence:

>1011_bases
GTGGTGATAGAAAAGATCTGGTTTCACCGCCATCCATTGGGTTATTTGTTATGGCCACTGTTGTGGCCATTCAGCGTACT
ATTTGGTGTCATCAGCCGCTCACGGCGTAAAGCATATCAAACGGGCGACAAACCCTCCTATCGTGCACCCTTACCCGTGG
TCGTGGTGGGTAACATTACAGCCGGTGGTAATGGCAAAACCCCTGTTGTGGTTTGGCTGGTGGAAACGCTGCAAAACCTT
GGCTATCGTCCGGGGGTCGTTTCACGTGGTTATGGCGCTAAAGCGCCCAGCTATCCGCTCGTGGTGAATGAGCAAACGCC
AGCTCAGCATTGCGGTGATGAGCCGAAACTCATTTTTCAGCGTACCAAAGCGCCTGTAGCGGTCGATCCTGTACGCAGCC
AAGCGGTAAAAGCGCTGCTTGAGCACGGGGTCAATGTCATCGTTACGGATGATGGCTTGCAGCACTATGCGCTGCAGCGC
GATATTGAAATTGCAGTAGTGGACGGCGTTCGCCGTTTCGGTAACCAGGAATTGATCCCTTTAGGTCCTCTGCGTGAACC
TGTCAGCCGACTCGATGAAGTCGATTTCATTATCACTAATGGTGGCGTGGCAAAGGCCAATGAAATCGCAATGCGTCTGC
AACCGACGGATGCGGTGAATCTTAAGACGGGTGAACGCTGTGCAGTGAGTAAGCTCACTCGCTTGTGCGCCATGGCTGGG
ATTGGCCATCCTTCCCGATTTTTTAATACTTTGCGTGAACTCAATGCCGATTTAGTTCATTGCCAAGGTTTTGCCGATCA
TCAAGCCTTTGATGCTGCTCAGTTAAATCAACTGGCGCAGCAAGGCGATCATCTGATCATGACAGAAAAAGATGCCGTAA
AATGCGCTGAGTTTGCCCAGCCAAATTGGTGGTATCTGCCCGTTTCGGCTCAGTTTGCTCCAGAAGCGGAGCAGCGTATT
GTGGACAAAATTAAAGAGGTAATGGAACCGTATGGATCACCGTCTGCTTGA

Upstream 100 bases:

>100_bases
TGGTTGATGAAGGTGAAATCATTGAGCGTGGTCGCCATGCTGATCTGTTGGCGCAAGATGGCGCATACGCTCAGCTGCAT
CGCATCCAGTTTGGTGAATA

Downstream 100 bases:

>100_bases
AATCGTCGCTTGCCCAGTATGTAAAGGTAAGCTGACTTACGATAAAGATCGCCAAGAGCTGATTTGTAAGCTGGATCGTC
TGGCTTATCCCATTAAAGAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGDHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA

Sequences:

>Translated_336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGDHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA
>Mature_336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGDHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=56, Blast_Score=358, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37172; Mature: 37172

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNIT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
AGGNGKTPVVVWLVETLQNLGYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQ
ECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCCHHHHH
RTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQRDIEIAVVDGVRRFGNQELIP
HCCCCEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEHHHHHHCCCCCCC
LGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGDHLIMTEKDAVKCAEFAQ
CCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCC
PNWWYLPVSAQFAPEAEQRIVDKIKEVMEPYGSPSA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNIT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
AGGNGKTPVVVWLVETLQNLGYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQ
ECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCCHHHHH
RTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQRDIEIAVVDGVRRFGNQELIP
HCCCCEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEHHHHHHCCCCCCC
LGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGDHLIMTEKDAVKCAEFAQ
CCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCC
PNWWYLPVSAQFAPEAEQRIVDKIKEVMEPYGSPSA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]