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The map label for this gene is plsC [H]

Identifier: 147674609

GI number: 147674609

Start: 2254750

End: 2255535

Strand: Reverse

Name: plsC [H]

Synonym: VC0395_A2095

Alternate gene names: 147674609

Gene position: 2255535-2254750 (Counterclockwise)

Preceding gene: 147674274

Following gene: 147674124

Centisome position: 74.59

GC content: 49.36

Gene sequence:

>786_bases
ATGGGCCGAAATCCAAGGGTTTCGGCCTTTTTCTTCCAGTGCCTTCGGAGAAGTTGCATGATTGCGTTATTGCGAATCTT
GGCAGTGGCAGTGTTCGCTGTCTATATGTTTGTGTTTGGCTGCGGTTACTGTTTGTTCAGTCCACGTAACCCTAAGCATG
TTTATACCTTTGGTAAGCAGTTTGCGGCGATGTCGAAAGTGTTCGGTATTAAGCTTGAATACCGCGCTCCGGCCGATGTC
GATCAGCGTGGTCAGCACATTTATATTGCTAACCACCAGAATAACTGGGATCTGTTTACCGTTTCTAAAGCGGTAACGCC
AAAAGTGGTCACCGTCGGTAAGAAAAGTCTCGCGTGGATGCCACTGTTTGGTCAGCTTTATTGGTTGACGGGCAATATCC
TGATTGATCGCGCCAACAAAGCCAAAGCCAAAGGCACCATTGATCAAGTGGTTGATTCGATGAAACAGAGCGATGTTTCG
GTGTGGATGTTTCCGGAAGGTACGCGCTCGCGTGGTCGCGGTTTATTGCCGTTTAAAGCGGGCGCTTTCCATGCGGCGAT
TGGTGCGGGTGTGCCGATTATTCCTATCGTGTGTAGCTCGACCGATAAGCTTAAATTCAACCGTTGGAACAACGGGCATG
TGATTGTCGAAGTGTTGCCTCCCATCAGCACTGAAGGCTACAGCAAAGAGAATATCCGCGAGCTGTCACAGCACTGTTAT
GATCTGATGAAAGCCAAACTGGCACAGTTGGATGCCGAAGTGGCTGAGCTGAACCGTAAAGCCTAG

Upstream 100 bases:

>100_bases
TCACATTGATCGTGGTTACGAGCGAATTGAGGACAAACTCTCAGCGCTTGGTGCCAATATTGAGCGTTTCCGCGACTAGC
GTTAAACTCCTCATTCATGA

Downstream 100 bases:

>100_bases
CCGCAGTTTTGATCAAAACGAATAAAAAGAAAGGGTTGCCACTGGCAACCCTTTTGGTATTTGAGATCCAATAAAATGGA
TTACTTGCGTACTGCGATCG

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MGRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQFAAMSKVFGIKLEYRAPADV
DQRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVS
VWMFPEGTRSRGRGLLPFKAGAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCY
DLMKAKLAQLDAEVAELNRKA

Sequences:

>Translated_261_residues
MGRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQFAAMSKVFGIKLEYRAPADV
DQRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVS
VWMFPEGTRSRGRGLLPFKAGAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCY
DLMKAKLAQLDAEVAELNRKA
>Mature_260_residues
GRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQFAAMSKVFGIKLEYRAPADVD
QRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWMPLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVSV
WMFPEGTRSRGRGLLPFKAGAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCYD
LMKAKLAQLDAEVAELNRKA

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=249, Percent_Identity=29.718875502008, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI15100175, Length=249, Percent_Identity=29.718875502008, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI6041665, Length=194, Percent_Identity=29.3814432989691, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789395, Length=238, Percent_Identity=58.8235294117647, Blast_Score=308, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17568319, Length=216, Percent_Identity=34.7222222222222, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17564032, Length=180, Percent_Identity=35, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320151, Length=195, Percent_Identity=33.8461538461538, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281364648, Length=258, Percent_Identity=29.0697674418605, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24582856, Length=258, Percent_Identity=29.0697674418605, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24582854, Length=258, Percent_Identity=29.0697674418605, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24641614, Length=197, Percent_Identity=35.5329949238579, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641612, Length=197, Percent_Identity=35.5329949238579, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 29253; Mature: 29121

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCCHHHHHHHH
FAAMSKVFGIKLEYRAPADVDQRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWM
HHHHHHHHCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEECCCCCEEEC
PLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVSVWMFPEGTRSRGRGLLPFKA
HHHHEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCC
GAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCY
CCHHHHHHCCCCEEEEEECCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
DLMKAKLAQLDAEVAELNRKA
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GRNPRVSAFFFQCLRRSCMIALLRILAVAVFAVYMFVFGCGYCLFSPRNPKHVYTFGKQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCCHHHHHHHH
FAAMSKVFGIKLEYRAPADVDQRGQHIYIANHQNNWDLFTVSKAVTPKVVTVGKKSLAWM
HHHHHHHHCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEECCCCCEEEC
PLFGQLYWLTGNILIDRANKAKAKGTIDQVVDSMKQSDVSVWMFPEGTRSRGRGLLPFKA
HHHHEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCC
GAFHAAIGAGVPIIPIVCSSTDKLKFNRWNNGHVIVEVLPPISTEGYSKENIRELSQHCY
CCHHHHHHCCCCEEEEEECCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
DLMKAKLAQLDAEVAELNRKA
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]