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The map label for this gene is folK-1 [H]

Identifier: 147673898

GI number: 147673898

Start: 49147

End: 49653

Strand: Direct

Name: folK-1 [H]

Synonym: VC0395_A0053

Alternate gene names: 147673898

Gene position: 49147-49653 (Clockwise)

Preceding gene: 147674486

Following gene: 147674526

Centisome position: 1.63

GC content: 48.72

Gene sequence:

>507_bases
ATGATCACCGCTTATATTGGTGTGGGCTCAAATCAGGATCGCCATCAGTCGATTGAAGCTGGCCTTCGTGCATTAGCCGA
GCTGGCGAGCCAGTGGCGTCTGTCCACGATTTATGAGTGTCCATCCGTTGGGTTTGCCAGCCATCCTTTCTTCAATCTGA
TGGTTGAGATGGAGACAGAGCTCGCGCTGCCTGAATTGATGAAGCAGTTAAAAGCGATCGAGCTGCGTTGTGGCCGTTTG
CCGAATGCACAAAAGTATCAGGATCGAACACTGGATCTTGATATTGTGCTGTATGGCGATTGTGTATCGGAGAATGATCC
AGTGCTGCCTCGACCGGATATCTATCGCTATCCGTTTGTGATTCAACCTTTATATGAGCTCTGTCCGCAGCGAGTGATTG
CTGGTGATGGTCGAACTGTTGAGCAGATTTGGCAACAAGCGCAGGATTTAGCATCACTCACCCCAGTACCGATCTGGTTT
TCTATTAACGAGAAGAAACAATCATGA

Upstream 100 bases:

>100_bases
TGACTCGCTTTGCTGTGCCTTGGCTCCGCATCCGCTTGACCAAGCCGGGCGCAGTGCCGCAAGCCAAAGGAGTCGGCGTG
ATCATCGAGCGAGCGCGTGG

Downstream 100 bases:

>100_bases
GTTATTTTGAGTCGTTCATTCTGGCTTTAATTCAAGGCTTTACCGAGTTTTTACCGATTTCTAGCTCCGCACACCTGATC
TTGCCTTCGGCTATTTTAGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MITAYIGVGSNQDRHQSIEAGLRALAELASQWRLSTIYECPSVGFASHPFFNLMVEMETELALPELMKQLKAIELRCGRL
PNAQKYQDRTLDLDIVLYGDCVSENDPVLPRPDIYRYPFVIQPLYELCPQRVIAGDGRTVEQIWQQAQDLASLTPVPIWF
SINEKKQS

Sequences:

>Translated_168_residues
MITAYIGVGSNQDRHQSIEAGLRALAELASQWRLSTIYECPSVGFASHPFFNLMVEMETELALPELMKQLKAIELRCGRL
PNAQKYQDRTLDLDIVLYGDCVSENDPVLPRPDIYRYPFVIQPLYELCPQRVIAGDGRTVEQIWQQAQDLASLTPVPIWF
SINEKKQS
>Mature_168_residues
MITAYIGVGSNQDRHQSIEAGLRALAELASQWRLSTIYECPSVGFASHPFFNLMVEMETELALPELMKQLKAIELRCGRL
PNAQKYQDRTLDLDIVLYGDCVSENDPVLPRPDIYRYPFVIQPLYELCPQRVIAGDGRTVEQIWQQAQDLASLTPVPIWF
SINEKKQS

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=148, Percent_Identity=35.8108108108108, Blast_Score=82, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19142; Mature: 19142

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITAYIGVGSNQDRHQSIEAGLRALAELASQWRLSTIYECPSVGFASHPFFNLMVEMETE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LALPELMKQLKAIELRCGRLPNAQKYQDRTLDLDIVLYGDCVSENDPVLPRPDIYRYPFV
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
IQPLYELCPQRVIAGDGRTVEQIWQQAQDLASLTPVPIWFSINEKKQS
HHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC
>Mature Secondary Structure
MITAYIGVGSNQDRHQSIEAGLRALAELASQWRLSTIYECPSVGFASHPFFNLMVEMETE
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LALPELMKQLKAIELRCGRLPNAQKYQDRTLDLDIVLYGDCVSENDPVLPRPDIYRYPFV
HHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
IQPLYELCPQRVIAGDGRTVEQIWQQAQDLASLTPVPIWFSINEKKQS
HHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]