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The map label for this gene is tmk

Identifier: 147673617

GI number: 147673617

Start: 1723338

End: 1723976

Strand: Reverse

Name: tmk

Synonym: VC0395_A1602

Alternate gene names: 147673617

Gene position: 1723976-1723338 (Counterclockwise)

Preceding gene: 147674599

Following gene: 147674380

Centisome position: 57.01

GC content: 48.36

Gene sequence:

>639_bases
ATGAACGCAAAATTTATCGTAATTGAAGGTCTTGAAGGGGCGGGCAAAAGCACGGCGATTCAAGTGGTGGTAGAAACCTT
ACAGCAAAATGGGATTGATCACATCACTCGCACTCGTGAACCCGGCGGTACGCTGCTGGCTGAGAAGCTGCGCGCGTTAG
TGAAAGAAGAGCACCCGGGCGAAGAGCTTCAAGATATTACTGAGTTACTCTTGGTGTATGCCGCGCGAGTACAACTGGTG
GAAAATGTTATTAAACCCGCGTTAGCAAGAGGTGAGTGGGTGGTCGGTGATCGCCATGATATGTCTTCTCAAGCTTATCA
AGGTGGTGGCCGACAAATTGCACCAAGCACGATGCAAAGCCTCAAACAGACCGCGCTTGGGGATTTCAAACCCGACTTAA
CCTTATATTTGGATATCGACCCTAAGCTTGGTTTGGAACGTGCTCGCGGCCGTGGTGAGTTGGATCGCATTGAAAAAATG
GACATCAGCTTTTTTGAGCGTGCTCGTGAGCGTTACCTTGAATTAGCCAATAGCGATGATTCTGTGGTTATGATTGATGC
AGCACAGTCGATTGAACAGGTCACGGCCGATATTCGTCGTGCTTTACAAGATTGGTTGAGTCAAGTTAACCGTGTCTAA

Upstream 100 bases:

>100_bases
ACTTTGTGGCAAGCGGTGAGGGTGGACACAATTTCTCTAAGACACTCGCAGATCATAACCGTGCTGTGCGTGCTTATCTC
AAAAAACTTAGAACAAAACA

Downstream 100 bases:

>100_bases
TCTCAATTCTCTTTACCCTTGGTTAGTTCCCGTTTGGCAGCCTTGGCAAGCGGGATTAGCTGCAGGAAAAATCTCGTCAG
CGACGTTAATTCAGGCATCA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEHPGEELQDITELLLVYAARVQLV
ENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTMQSLKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKM
DISFFERARERYLELANSDDSVVMIDAAQSIEQVTADIRRALQDWLSQVNRV

Sequences:

>Translated_212_residues
MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEHPGEELQDITELLLVYAARVQLV
ENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTMQSLKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKM
DISFFERARERYLELANSDDSVVMIDAAQSIEQVTADIRRALQDWLSQVNRV
>Mature_212_residues
MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEHPGEELQDITELLLVYAARVQLV
ENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTMQSLKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKM
DISFFERARERYLELANSDDSVVMIDAAQSIEQVTADIRRALQDWLSQVNRV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=212, Percent_Identity=59.4339622641509, Blast_Score=247, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_VIBC3 (A5F6P9)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F6P9
- SMR:   A5F6P9
- STRING:   A5F6P9
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1602
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   VCHO345073:VC0395_A1602-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23666; Mature: 23666

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEHPG
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCC
EELQDITELLLVYAARVQLVENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCCEECHHHHHH
LKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKMDISFFERARERYLELANSDD
HHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVVMIDAAQSIEQVTADIRRALQDWLSQVNRV
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEHPG
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCC
EELQDITELLLVYAARVQLVENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTMQS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHCCCCCEECHHHHHH
LKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKMDISFFERARERYLELANSDD
HHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SVVMIDAAQSIEQVTADIRRALQDWLSQVNRV
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA