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The map label for this gene is fabH-1

Identifier: 147673193

GI number: 147673193

Start: 1729427

End: 1730377

Strand: Reverse

Name: fabH-1

Synonym: VC0395_A1609

Alternate gene names: 147673193

Gene position: 1730377-1729427 (Counterclockwise)

Preceding gene: 147675180

Following gene: 147673966

Centisome position: 57.22

GC content: 49.53

Gene sequence:

>951_bases
ATGTATAGCAAAATTTTAGGTACTGGCAGCTACTTGCCATCTCAGGTGCGTACTAACGCAGACTTAGAGAAAATGGTAGA
GACCAGTGATGAGTGGATTGTTGCTCGTACTGGTATTCGCGAGCGTCGTATTGCGGCTGACAATGAAACCGTTGCCGATA
TGGCATTCTTCGCTGCACAAAATGCCATAAACATGGCCGGTATTGATAAACACGACATCGATATGATTATTGTGGCGACC
ACCAGTGCGAGCCACACTTTCCCATCAGCCGCTTGCCAAGTGCAAGGCAAACTGGGAATTAAAGGATGTCCAGCGTTTGA
TTTGGCCGCAGCGTGTTCTGGTTTTATGTACGCGCTCTCTATTGCTGATCAGCATGTCAAATCTGGCATGTGCAAACATG
TTTTGGTGATTGGTGCGGATGCGTTGTCCAAAACCTGTGACCCCACAGATCGTTCGACCATTATCTTATTTGGGGATGGT
GCTGGCGCGGTAGTGGTGGGCGCAAGTAACGAGCCGGGCATTCTTTCTACTCACATCCACGCGGATGGCGAGTTTGGTGA
TTTACTGAGCCTTGAAGTGCCTGTTCGTGGTGGTGATAGCGATAAATGGCTGCACATGGCGGGGAACGAAGTGTTCAAAG
TCGCAGTAACTCAACTATCTAAACTGGTAGTTGATACGCTGAAAGCCAACAACATGCACAAGTCTGAGCTCGATTGGTTG
GTACCACATCAAGCGAACTACCGGATTATCTCAGCAACCGCGAAAAAACTTTCGATGTCGCTCGATCAGGTGGTGATTAC
CTTAGACCGTCATGGCAACACCTCTGCGGCGACTGTGCCTACAGCGTTGGATGAAGCCGTGCGTGATGGTCGTATTCAGC
GTGGGCAGATGCTACTGCTCGAAGCTTTTGGTGGTGGTTTCACATGGGGCTCTGCTCTGGTGAAGTTCTAA

Upstream 100 bases:

>100_bases
ATGCGATTTCTGAAGCGGTGCATGAGGTGAAACGACAAGTACCCAGCCGTATAAGCGATCGTTTGGAAGCGGTTTTACTC
GAGAGGCATTATTAGTCTTC

Downstream 100 bases:

>100_bases
ACGCACAATGAATTTTGACTTTAAGGAGTCCTAGGACTCCTTATCCATTCTTAGATGAAGGAAAGATTTATGAGTAAGTT
TGCTATCGTATTTCCAGGTC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Beta-ketoacyl-ACP synthase III 1; KAS III 1

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MYSKILGTGSYLPSQVRTNADLEKMVETSDEWIVARTGIRERRIAADNETVADMAFFAAQNAINMAGIDKHDIDMIIVAT
TSASHTFPSAACQVQGKLGIKGCPAFDLAAACSGFMYALSIADQHVKSGMCKHVLVIGADALSKTCDPTDRSTIILFGDG
AGAVVVGASNEPGILSTHIHADGEFGDLLSLEVPVRGGDSDKWLHMAGNEVFKVAVTQLSKLVVDTLKANNMHKSELDWL
VPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQMLLLEAFGGGFTWGSALVKF

Sequences:

>Translated_316_residues
MYSKILGTGSYLPSQVRTNADLEKMVETSDEWIVARTGIRERRIAADNETVADMAFFAAQNAINMAGIDKHDIDMIIVAT
TSASHTFPSAACQVQGKLGIKGCPAFDLAAACSGFMYALSIADQHVKSGMCKHVLVIGADALSKTCDPTDRSTIILFGDG
AGAVVVGASNEPGILSTHIHADGEFGDLLSLEVPVRGGDSDKWLHMAGNEVFKVAVTQLSKLVVDTLKANNMHKSELDWL
VPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQMLLLEAFGGGFTWGSALVKF
>Mature_316_residues
MYSKILGTGSYLPSQVRTNADLEKMVETSDEWIVARTGIRERRIAADNETVADMAFFAAQNAINMAGIDKHDIDMIIVAT
TSASHTFPSAACQVQGKLGIKGCPAFDLAAACSGFMYALSIADQHVKSGMCKHVLVIGADALSKTCDPTDRSTIILFGDG
AGAVVVGASNEPGILSTHIHADGEFGDLLSLEVPVRGGDSDKWLHMAGNEVFKVAVTQLSKLVVDTLKANNMHKSELDWL
VPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQMLLLEAFGGGFTWGSALVKF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=72.5552050473186, Blast_Score=481, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH1_VIBCH (Q9KQH5)

Other databases:

- EMBL:   AE003852
- PIR:   H82128
- RefSeq:   NP_231657.1
- ProteinModelPortal:   Q9KQH5
- SMR:   Q9KQH5
- GeneID:   2613402
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC2023
- TIGR:   VC_2023
- HOGENOM:   HBG649927
- OMA:   YLPAQVR
- ProtClustDB:   PRK09352
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33749; Mature: 33749

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 243-243 ACT_SITE 273-273

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKILGTGSYLPSQVRTNADLEKMVETSDEWIVARTGIRERRIAADNETVADMAFFAAQ
CCCCEECCCCCCCHHHHCCCCHHHHHCCCCCEEEEECCCCHHEECCCCCHHHHHHHHHHH
NAINMAGIDKHDIDMIIVATTSASHTFPSAACQVQGKLGIKGCPAFDLAAACSGFMYALS
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
IADQHVKSGMCKHVLVIGADALSKTCDPTDRSTIILFGDGAGAVVVGASNEPGILSTHIH
HHHHHHHCCHHEEEEEEECHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGEFGDLLSLEVPVRGGDSDKWLHMAGNEVFKVAVTQLSKLVVDTLKANNMHKSELDWL
CCCCCCCEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQMLLL
CCCCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEE
EAFGGGFTWGSALVKF
EECCCCCCHHHHHHCC
>Mature Secondary Structure
MYSKILGTGSYLPSQVRTNADLEKMVETSDEWIVARTGIRERRIAADNETVADMAFFAAQ
CCCCEECCCCCCCHHHHCCCCHHHHHCCCCCEEEEECCCCHHEECCCCCHHHHHHHHHHH
NAINMAGIDKHDIDMIIVATTSASHTFPSAACQVQGKLGIKGCPAFDLAAACSGFMYALS
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
IADQHVKSGMCKHVLVIGADALSKTCDPTDRSTIILFGDGAGAVVVGASNEPGILSTHIH
HHHHHHHCCHHEEEEEEECHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEEEEE
ADGEFGDLLSLEVPVRGGDSDKWLHMAGNEVFKVAVTQLSKLVVDTLKANNMHKSELDWL
CCCCCCCEEEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
VPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQMLLL
CCCCCCEEEEEEHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEE
EAFGGGFTWGSALVKF
EECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301