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The map label for this gene is mtnP [H]

Identifier: 146343662

GI number: 146343662

Start: 7175256

End: 7176131

Strand: Reverse

Name: mtnP [H]

Synonym: BRADO6904

Alternate gene names: 146343662

Gene position: 7176131-7175256 (Counterclockwise)

Preceding gene: 146343663

Following gene: 146343661

Centisome position: 96.24

GC content: 65.75

Gene sequence:

>876_bases
ATGACGAAGGCTGTGCTTGGCATTATCGGCGGATCAGGCATCTATGATCTGCCGGGGTTGGAAGACGCACACGAGGAGGC
GATCGCGAGCCCGTGGGGCGAGCCGTCGGCGCCGCTGCGGCGCGGAACCATCGCGGGCCTGCCGATCGTGTTTCTGCCGC
GTCACGACAAGGGACACCGGCTGTCGCCGTCGGACATCAACTATCGCGCCAATATCGATGTGCTGAAGCGGGCGGGGGTC
ACCGACCTCGTGTCACTGTCCGCCTGCGGCTCGTTCAAGGAGGAGCTGCCGCCTGGCACCTTCGTGCTGGTCGACCAGTT
CGTCGATCGCACCTACAAGCGCGAGAGCTCGTTCTTCGGCAAAGGCTGCGTCGCGCATGTGTCGATGGCGCATCCGGTGT
CGCCGCGGCTGCGTATCCATCTCGCCGCGGCGGCGGAGGCGGAAGGCATCGCGGTCGCGCGCGGCGGGACCTATGTCTGC
ATGGAGGGTCCGCAGTTCTCGACCTATGCCGAGAGTATGACCTACAAGGCGGCCGGCTATTCGGTCATCGGCATGACCAA
CATGCCCGAGGCCAAGCTCGCCCGCGAGGCTGAGATCTGCTATGCGACCGTCGCGATGGTGACCGACTTCGACTGCTGGC
ATCCGGACCATGACGCCGTGACGGTGCAGGACATCATCCGCGTGCTCACCACCAATGCCGACAAAGCCAAATCGCTGGTC
GCGCGGCTCGCCCGTGAGTTTCCGCGTGAACACGAGCCGTGTCCGATCGGCTCCGACCGCGCGCTCGACACCGCGTTGAT
CACGGCGCCTGAGGCGCGCGATCCCGAACTCCTCAAGAAGCTCGATGCGGTCGCTGGCCGCCTTCTGCGCGGCTGA

Upstream 100 bases:

>100_bases
GCGGCCTGAACCCCGACAGGCATCCCGCGCGCCGCCCGCATCCCGGTTTTCAACGCAGTTCAAAACTGGCATTCTCGACT
CCGATGGAGACGGGGACGTC

Downstream 100 bases:

>100_bases
CGGGAGATCGACGATGAAGGTGGACGGCAAGCATTATCGCAGCATATGGCTCGATGCCGACGGCTGGACGGTCTGTGCGA
TCGATCAGCGGCGGCTGCCG

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTKAVLGIIGGSGIYDLPGLEDAHEEAIASPWGEPSAPLRRGTIAGLPIVFLPRHDKGHRLSPSDINYRANIDVLKRAGV
TDLVSLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGKGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAVARGGTYVC
MEGPQFSTYAESMTYKAAGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTTNADKAKSLV
ARLAREFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRLLRG

Sequences:

>Translated_291_residues
MTKAVLGIIGGSGIYDLPGLEDAHEEAIASPWGEPSAPLRRGTIAGLPIVFLPRHDKGHRLSPSDINYRANIDVLKRAGV
TDLVSLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGKGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAVARGGTYVC
MEGPQFSTYAESMTYKAAGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTTNADKAKSLV
ARLAREFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRLLRG
>Mature_290_residues
TKAVLGIIGGSGIYDLPGLEDAHEEAIASPWGEPSAPLRRGTIAGLPIVFLPRHDKGHRLSPSDINYRANIDVLKRAGVT
DLVSLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFGKGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAVARGGTYVCM
EGPQFSTYAESMTYKAAGYSVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTTNADKAKSLVA
RLAREFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRLLRG

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=244, Percent_Identity=43.8524590163934, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71980569, Length=250, Percent_Identity=41.2, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323045, Length=296, Percent_Identity=36.8243243243243, Blast_Score=169, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20130079, Length=250, Percent_Identity=41.6, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI221459247, Length=250, Percent_Identity=31.2, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 31426; Mature: 31295

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAVLGIIGGSGIYDLPGLEDAHEEAIASPWGEPSAPLRRGTIAGLPIVFLPRHDKGHR
CCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
LSPSDINYRANIDVLKRAGVTDLVSLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFG
CCCCCCCEECCHHHHHHCCHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
KGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAVARGGTYVCMEGPQFSTYAESMTYKAAGY
CCHHHEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCHHHHHHHEECCCCE
SVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTTNADKAKSLV
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHH
ARLAREFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRLLRG
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKAVLGIIGGSGIYDLPGLEDAHEEAIASPWGEPSAPLRRGTIAGLPIVFLPRHDKGHR
CCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
LSPSDINYRANIDVLKRAGVTDLVSLSACGSFKEELPPGTFVLVDQFVDRTYKRESSFFG
CCCCCCCEECCHHHHHHCCHHHHHHHHHCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
KGCVAHVSMAHPVSPRLRIHLAAAAEAEGIAVARGGTYVCMEGPQFSTYAESMTYKAAGY
CCHHHEEECCCCCCCCEEEEEEECCCCCCEEEECCCEEEEECCCCCHHHHHHHEECCCCE
SVIGMTNMPEAKLAREAEICYATVAMVTDFDCWHPDHDAVTVQDIIRVLTTNADKAKSLV
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHH
ARLAREFPREHEPCPIGSDRALDTALITAPEARDPELLKKLDAVAGRLLRG
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA