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The map label for this gene is yngE [H]

Identifier: 146343636

GI number: 146343636

Start: 7142469

End: 7144085

Strand: Reverse

Name: yngE [H]

Synonym: BRADO6876

Alternate gene names: 146343636

Gene position: 7144085-7142469 (Counterclockwise)

Preceding gene: 146343637

Following gene: 146343635

Centisome position: 95.81

GC content: 68.83

Gene sequence:

>1617_bases
ATGGCCATCATCGACAACACCATCTCTCCCACGGGCGCCGCCTTTCAAACCAATCGCGACGGCATGCTCGGGCTGATCGC
GCGGATGCGCGAACTGGAGGCGCGGACGCGCAAGGCCTCTGCGGCGGCCAAGGACCGCTTCCATCAGCGCGGCCAGCTGC
TGCCGCGCGAGCGCGTCGCGCTTGTGCTCGATCCCGGTGCGCCGTTTCTGGAGCTGTCGACGCTCGCCGGCTACATGTTC
GATACGCCGGATCCGGCGAAGAGCGTGCCGGGCGGCGGCGTGATCGCCGGCATCGGCTTCGTCTCGGGCGTGCGCTGCAT
GGTGTCGGCCAACGACGCGGCCATCGATGCCGGCGCGCTGCAGCCCTACGGCCTCGATAAGACGCTGCGCGTGCAGGAGC
TGGCGCTGGAGAACAGGCTGCCTTACGTGCAACTGGTGGAGAGCGCCGGCGCCAACCTCTTGCGCTACCGCGTCGAGGAC
TTCGTGCGCGGCGGCAACATCTTTCGCAATTTGGCGCGGCTGTCGGCAGCGGGGCTCCCCGTGGTGACCGTGACGCACGG
CTCGTCGACCGCGGGCGGCGCCTACCAGACCGGTCTGTCCGACTACATCGTCATGGTCCGCGGCCGCACTCGCGCCTTCC
TCGCGGGGCCGCCGCTGCTGAAGGCCGCGACCGGCGAGATCGCCACCGAGGAGGAGCTCGGCGGCGCCGAGATGCACACC
GCGATCTCCGGCCTCGGCGACTATCTCGCCGAGGACGATCGCGACGGCTTGCGCATCGCGCGCGAGATCATGGGCAGGCT
GAACTGGGACCGGCCGTCGCACGAAGCGTGCGCGGCAAAGCCGCCGCGCTACGATCAGGAGGAGCTGCTCGGCATCATGC
CGCTCGATCACAAGCGCCCCGTCGACATGCGCCAGGTGATCGCGCGGATCGTCGACGACAGCGATTTCGTCGAGATGTCG
CCGAACTACGGCCCTGCGACCGTGTGCGGCCATGCCCGGATCGAGGGCGAGGCGATCGGCATCGTCACCAACAATGGCCC
GCTTGACCCGGCCGGCGCCAACAAGGCGACGCATTTCATCCAGGCCTGCTGCCAGAGCCGCACGCCGATCCTCTACCTCA
ACAACACCACCGGCTACATGGTCGGCCGCGCCTATGAGGAGGCCGGCATGATCAAGCACGGCTCCAAGATGATCCAGGCG
GTGACTTCGGCGACGGTGCCGCAGATCACGATCTATTGCGGCGCCTCGTTCGGCGCCGGCAATTACGGCATGTGCGGCCG
CGGCTTCCATCCGCGCTTCTGCTTCTCATGGCCGAACGCCAAGACGGCTGTCATGGGCGGCGAGCAGGCGGCCGAGACGA
TGGCGATCGTCACGGAGGCGGCCGCGGCCCGCCGCGGCAAACCGGTCGAGCGCGACAAGCTCGATGCCATGAAGGCGCAG
ATCATCGGCGTGTTCGACAGCCAGATGGACGTGTTCGCGACGTCGGCGCGCGTGCTCGACGACGGCGTGATCGATCCGCG
CGACACCCGCGCGGTGCTGTCGGAGGTGCTGGCGATCTGCCGCGAGGCCGAAGCGCGCGCGCCGCAGCGGATGCAGTTCT
CGGTGGCCCGGCCATGA

Upstream 100 bases:

>100_bases
AAGCAATCCAGGGGCCAAACAGGAAGTCTGGATTGCTTCGTCGCTGCGCTCCTCGCAATGACGAACTCGTTAATCCCAAG
GTACTCGTAAGCCAAACTCC

Downstream 100 bases:

>100_bases
CAAGGGACATCAGCGGAGAGAAGACGATGTCGCGCAGGCCCTTCCACAAGGTGCTGATCGCCAACCGCGGCGAGATTGCG
CTGCGTGTGATGCGGACCGC

Product: putative carboxylase substrate acetyl-CoA, propionyl-CoA, methylcrotonoyl-CoA

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MAIIDNTISPTGAAFQTNRDGMLGLIARMRELEARTRKASAAAKDRFHQRGQLLPRERVALVLDPGAPFLELSTLAGYMF
DTPDPAKSVPGGGVIAGIGFVSGVRCMVSANDAAIDAGALQPYGLDKTLRVQELALENRLPYVQLVESAGANLLRYRVED
FVRGGNIFRNLARLSAAGLPVVTVTHGSSTAGGAYQTGLSDYIVMVRGRTRAFLAGPPLLKAATGEIATEEELGGAEMHT
AISGLGDYLAEDDRDGLRIAREIMGRLNWDRPSHEACAAKPPRYDQEELLGIMPLDHKRPVDMRQVIARIVDDSDFVEMS
PNYGPATVCGHARIEGEAIGIVTNNGPLDPAGANKATHFIQACCQSRTPILYLNNTTGYMVGRAYEEAGMIKHGSKMIQA
VTSATVPQITIYCGASFGAGNYGMCGRGFHPRFCFSWPNAKTAVMGGEQAAETMAIVTEAAAARRGKPVERDKLDAMKAQ
IIGVFDSQMDVFATSARVLDDGVIDPRDTRAVLSEVLAICREAEARAPQRMQFSVARP

Sequences:

>Translated_538_residues
MAIIDNTISPTGAAFQTNRDGMLGLIARMRELEARTRKASAAAKDRFHQRGQLLPRERVALVLDPGAPFLELSTLAGYMF
DTPDPAKSVPGGGVIAGIGFVSGVRCMVSANDAAIDAGALQPYGLDKTLRVQELALENRLPYVQLVESAGANLLRYRVED
FVRGGNIFRNLARLSAAGLPVVTVTHGSSTAGGAYQTGLSDYIVMVRGRTRAFLAGPPLLKAATGEIATEEELGGAEMHT
AISGLGDYLAEDDRDGLRIAREIMGRLNWDRPSHEACAAKPPRYDQEELLGIMPLDHKRPVDMRQVIARIVDDSDFVEMS
PNYGPATVCGHARIEGEAIGIVTNNGPLDPAGANKATHFIQACCQSRTPILYLNNTTGYMVGRAYEEAGMIKHGSKMIQA
VTSATVPQITIYCGASFGAGNYGMCGRGFHPRFCFSWPNAKTAVMGGEQAAETMAIVTEAAAARRGKPVERDKLDAMKAQ
IIGVFDSQMDVFATSARVLDDGVIDPRDTRAVLSEVLAICREAEARAPQRMQFSVARP
>Mature_537_residues
AIIDNTISPTGAAFQTNRDGMLGLIARMRELEARTRKASAAAKDRFHQRGQLLPRERVALVLDPGAPFLELSTLAGYMFD
TPDPAKSVPGGGVIAGIGFVSGVRCMVSANDAAIDAGALQPYGLDKTLRVQELALENRLPYVQLVESAGANLLRYRVEDF
VRGGNIFRNLARLSAAGLPVVTVTHGSSTAGGAYQTGLSDYIVMVRGRTRAFLAGPPLLKAATGEIATEEELGGAEMHTA
ISGLGDYLAEDDRDGLRIAREIMGRLNWDRPSHEACAAKPPRYDQEELLGIMPLDHKRPVDMRQVIARIVDDSDFVEMSP
NYGPATVCGHARIEGEAIGIVTNNGPLDPAGANKATHFIQACCQSRTPILYLNNTTGYMVGRAYEEAGMIKHGSKMIQAV
TSATVPQITIYCGASFGAGNYGMCGRGFHPRFCFSWPNAKTAVMGGEQAAETMAIVTEAAAARRGKPVERDKLDAMKAQI
IGVFDSQMDVFATSARVLDDGVIDPRDTRAVLSEVLAICREAEARAPQRMQFSVARP

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=512, Percent_Identity=46.2890625, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI119943100, Length=502, Percent_Identity=28.6852589641434, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI295821216, Length=522, Percent_Identity=27.5862068965517, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI310133460, Length=138, Percent_Identity=44.9275362318841, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17552936, Length=521, Percent_Identity=42.8023032629559, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25147359, Length=511, Percent_Identity=28.7671232876712, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147362, Length=511, Percent_Identity=28.7671232876712, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24586065, Length=555, Percent_Identity=42.3423423423423, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57787; Mature: 57656

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIDNTISPTGAAFQTNRDGMLGLIARMRELEARTRKASAAAKDRFHQRGQLLPRERVA
CCEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LVLDPGAPFLELSTLAGYMFDTPDPAKSVPGGGVIAGIGFVSGVRCMVSANDAAIDAGAL
EEECCCCCCEEHHHHHHHHCCCCCCHHCCCCCCEEEHHHHHCCEEEEEECCCCEECCCCC
QPYGLDKTLRVQELALENRLPYVQLVESAGANLLRYRVEDFVRGGNIFRNLARLSAAGLP
CCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
VVTVTHGSSTAGGAYQTGLSDYIVMVRGRTRAFLAGPPLLKAATGEIATEEELGGAEMHT
EEEEECCCCCCCCHHHCCCCEEEEEEECCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHH
AISGLGDYLAEDDRDGLRIAREIMGRLNWDRPSHEACAAKPPRYDQEELLGIMPLDHKRP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCC
VDMRQVIARIVDDSDFVEMSPNYGPATVCGHARIEGEAIGIVTNNGPLDPAGANKATHFI
CCHHHHHHHHHCCCCCEEECCCCCCEEEECCEEECCEEEEEEECCCCCCCCCCCHHHHHH
QACCQSRTPILYLNNTTGYMVGRAYEEAGMIKHGSKMIQAVTSATVPQITIYCGASFGAG
HHHHCCCCCEEEEECCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRGFHPRFCFSWPNAKTAVMGGEQAAETMAIVTEAAAARRGKPVERDKLDAMKAQ
CCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IIGVFDSQMDVFATSARVLDDGVIDPRDTRAVLSEVLAICREAEARAPQRMQFSVARP
HEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
AIIDNTISPTGAAFQTNRDGMLGLIARMRELEARTRKASAAAKDRFHQRGQLLPRERVA
CEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
LVLDPGAPFLELSTLAGYMFDTPDPAKSVPGGGVIAGIGFVSGVRCMVSANDAAIDAGAL
EEECCCCCCEEHHHHHHHHCCCCCCHHCCCCCCEEEHHHHHCCEEEEEECCCCEECCCCC
QPYGLDKTLRVQELALENRLPYVQLVESAGANLLRYRVEDFVRGGNIFRNLARLSAAGLP
CCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
VVTVTHGSSTAGGAYQTGLSDYIVMVRGRTRAFLAGPPLLKAATGEIATEEELGGAEMHT
EEEEECCCCCCCCHHHCCCCEEEEEEECCCEEEECCCCCHHHCCCCCCCHHHCCCHHHHH
AISGLGDYLAEDDRDGLRIAREIMGRLNWDRPSHEACAAKPPRYDQEELLGIMPLDHKRP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHEECCCCCCCC
VDMRQVIARIVDDSDFVEMSPNYGPATVCGHARIEGEAIGIVTNNGPLDPAGANKATHFI
CCHHHHHHHHHCCCCCEEECCCCCCEEEECCEEECCEEEEEEECCCCCCCCCCCHHHHHH
QACCQSRTPILYLNNTTGYMVGRAYEEAGMIKHGSKMIQAVTSATVPQITIYCGASFGAG
HHHHCCCCCEEEEECCCCEEEEHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRGFHPRFCFSWPNAKTAVMGGEQAAETMAIVTEAAAARRGKPVERDKLDAMKAQ
CCCCCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IIGVFDSQMDVFATSARVLDDGVIDPRDTRAVLSEVLAICREAEARAPQRMQFSVARP
HEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]