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The map label for this gene is accA1 [H]

Identifier: 146343635

GI number: 146343635

Start: 7140487

End: 7142442

Strand: Reverse

Name: accA1 [H]

Synonym: BRADO6875

Alternate gene names: 146343635

Gene position: 7142442-7140487 (Counterclockwise)

Preceding gene: 146343636

Following gene: 146343629

Centisome position: 95.79

GC content: 67.74

Gene sequence:

>1956_bases
ATGTCGCGCAGGCCCTTCCACAAGGTGCTGATCGCCAACCGCGGCGAGATTGCGCTGCGTGTGATGCGGACCGCGCGCCG
ACTCGGCTACCGCGTCGTCGCCGTCTACTCGGATGTCGACGCTGATGCCCCGCATGTCCGGCTTGCCGACCAGGCCGTTC
GCATCGGCGCGCCGCCGCCGGCGCAGTCCTATCTGAATATTGCCGCGATCATCGCCGCGGCCAAGGCGACCGGCGCGGAC
GCCGTGCATCCCGGCTACGGCTTTCTCGCCGAGAATGAGGATTTTGCTCAGGCCTGCAAGGACGCGGGTCTGGTCTTCGT
CGGCCCGTCACCGGATGCGATTGCGGCGATGGGCAACAAGGCCGGCGCGAAGACGATCATGCAGCGCGCCGGCGTACCCT
GCGTGCCCGGCTATCAGGGCGAGGATGGGGGTGACGAGGCGATGCTCCGCGAAGCGAAGCGCATCGGCTTCCCGGTGATG
ATCAAGGCCGTCGCCGGCGGCGGCGGTCGCGGTATGCGGCTCGTGAACGAGGCGTATGCATTCCCGGATCTGCTGCGCAG
CGCGCGCTCGGAGGCTGCTGCGGCGTTCGGCGACGGCACCGTCATCCTGGAGAAGGCGATCGCCAACCCGCGTCACATCG
AGATCCAGGTGTTCGGAGACAGCCATGGCAACGCCGTGCATCTCGGCGAGCGCGACTGCTCGGTGCAACGGCGGCACCAG
AAGCTGATCGAAGAGGCGCCGTCGCCGGCCGTCGGCCCGGAGCTACGCGCACGCATGGGTGCGGTCGCGGTGCAGGCGGT
CAAGGCGCTTGGCTATGAGGGAGCTGGGACGCTCGAATTCCTGCTCGATGGCGACGGCCGGTTCTACTTCATGGAAATGA
ATACGCGGCTGCAGGTCGAGCATCCCGTGACCGAGGCGTTGACGGGGCTCGATCTCGTCGAGTGGCAACTTCGCGTCGCC
GCCGGCGAGCCGCTACCGCTGCGTCAGGAGCAGATCAGCTTCGTTGGCCACGCCATTGAGGTCCGGCTGTGCTCGGAGGA
TGCGGCGCAGGATTTCATGCCACGATCCGGGCGCATGGCGCTGTGGCAGATGCCGGAGACGGTCCGCGTCGAGCATGCGC
TGGAATCGGGAACGGAGATTCCGCCGGACTACGATTCGATGATCGCCAAGCTGATCAGCCACGGCGCAACCCGTGAGGAG
GCGCGGGCCCGTCTGATCGTGGGTCTGGAGCAGGCGGTCGCGCTGGGCGTCGTGACCAACCAGTGGTTTCTGCTGTCCTG
TCTGCGGCACCCGGCGTTCGCGGCGGGCAAGGCGACCACAGCCTTCATCGCAACACATCGCGACGAGCTGAGGGCGCCCT
TGATCGCTGCGGAGGATATGGCGCTGCTCGCCGTGCTGCTCTCCGTCAGTCACCCGCTGGCGCATCCCGTCCGCCGGGGG
CGTTCGCTCGCCGCCACCTTTGCGACGCCGCTCCGTTTCGAGCTTGGCGGCGAGTTGAGGGAGTGCGAGCTGTCGCGCGA
TCGTGACGGCAGCTATTGTGTGACGCACAATGGCGCGGAGCAGCGCAGCGAGATCGTCACGCTCGATGCCGATACGATTC
GAATCCGCCGGGGCGACGTCGTCGACGTCGTCCGCTTCGCGCGCGACGGTGATCGGCTGTTCGTACAGTCGCGTGGTCGG
ACGCTGGTGCTGCGCGACCTCACGCTGGGGGCGCCGCAGTCCACCGCGGCGGCCGGCGGTGATGGCAAGGTGCGCGCCGC
GTTGAACGGCCGCGTCGTCGCCATGCTCGTCAAGGCCGGCGATCAGGTGGCCGCGGGACAGCCGGTGCTGACTCTGGAAG
CGATGAAGATGGAGCACGTCCACACGGCCGGCTTGGCCGGGACTGTGAGTGCGATCGCGGTCGCTGAGGGCGATCAGGTG
ACGACGGGACAGATCGTGATCGAGATCAAGCGGTGA

Upstream 100 bases:

>100_bases
AGGTGCTGGCGATCTGCCGCGAGGCCGAAGCGCGCGCGCCGCAGCGGATGCAGTTCTCGGTGGCCCGGCCATGACAAGGG
ACATCAGCGGAGAGAAGACG

Downstream 100 bases:

>100_bases
TTGCCGGGCCGTGGTTTCGCTGTCTGATCGGGTGAGGAGTTAAGCTGCGTCTCATCGCGGCAGTTGGCGCCGCAACGTTG
CGACCAGGCGCGACGTCTGG

Product: putative biotin carboxylase

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSRRPFHKVLIANRGEIALRVMRTARRLGYRVVAVYSDVDADAPHVRLADQAVRIGAPPPAQSYLNIAAIIAAAKATGAD
AVHPGYGFLAENEDFAQACKDAGLVFVGPSPDAIAAMGNKAGAKTIMQRAGVPCVPGYQGEDGGDEAMLREAKRIGFPVM
IKAVAGGGGRGMRLVNEAYAFPDLLRSARSEAAAAFGDGTVILEKAIANPRHIEIQVFGDSHGNAVHLGERDCSVQRRHQ
KLIEEAPSPAVGPELRARMGAVAVQAVKALGYEGAGTLEFLLDGDGRFYFMEMNTRLQVEHPVTEALTGLDLVEWQLRVA
AGEPLPLRQEQISFVGHAIEVRLCSEDAAQDFMPRSGRMALWQMPETVRVEHALESGTEIPPDYDSMIAKLISHGATREE
ARARLIVGLEQAVALGVVTNQWFLLSCLRHPAFAAGKATTAFIATHRDELRAPLIAAEDMALLAVLLSVSHPLAHPVRRG
RSLAATFATPLRFELGGELRECELSRDRDGSYCVTHNGAEQRSEIVTLDADTIRIRRGDVVDVVRFARDGDRLFVQSRGR
TLVLRDLTLGAPQSTAAAGGDGKVRAALNGRVVAMLVKAGDQVAAGQPVLTLEAMKMEHVHTAGLAGTVSAIAVAEGDQV
TTGQIVIEIKR

Sequences:

>Translated_651_residues
MSRRPFHKVLIANRGEIALRVMRTARRLGYRVVAVYSDVDADAPHVRLADQAVRIGAPPPAQSYLNIAAIIAAAKATGAD
AVHPGYGFLAENEDFAQACKDAGLVFVGPSPDAIAAMGNKAGAKTIMQRAGVPCVPGYQGEDGGDEAMLREAKRIGFPVM
IKAVAGGGGRGMRLVNEAYAFPDLLRSARSEAAAAFGDGTVILEKAIANPRHIEIQVFGDSHGNAVHLGERDCSVQRRHQ
KLIEEAPSPAVGPELRARMGAVAVQAVKALGYEGAGTLEFLLDGDGRFYFMEMNTRLQVEHPVTEALTGLDLVEWQLRVA
AGEPLPLRQEQISFVGHAIEVRLCSEDAAQDFMPRSGRMALWQMPETVRVEHALESGTEIPPDYDSMIAKLISHGATREE
ARARLIVGLEQAVALGVVTNQWFLLSCLRHPAFAAGKATTAFIATHRDELRAPLIAAEDMALLAVLLSVSHPLAHPVRRG
RSLAATFATPLRFELGGELRECELSRDRDGSYCVTHNGAEQRSEIVTLDADTIRIRRGDVVDVVRFARDGDRLFVQSRGR
TLVLRDLTLGAPQSTAAAGGDGKVRAALNGRVVAMLVKAGDQVAAGQPVLTLEAMKMEHVHTAGLAGTVSAIAVAEGDQV
TTGQIVIEIKR
>Mature_650_residues
SRRPFHKVLIANRGEIALRVMRTARRLGYRVVAVYSDVDADAPHVRLADQAVRIGAPPPAQSYLNIAAIIAAAKATGADA
VHPGYGFLAENEDFAQACKDAGLVFVGPSPDAIAAMGNKAGAKTIMQRAGVPCVPGYQGEDGGDEAMLREAKRIGFPVMI
KAVAGGGGRGMRLVNEAYAFPDLLRSARSEAAAAFGDGTVILEKAIANPRHIEIQVFGDSHGNAVHLGERDCSVQRRHQK
LIEEAPSPAVGPELRARMGAVAVQAVKALGYEGAGTLEFLLDGDGRFYFMEMNTRLQVEHPVTEALTGLDLVEWQLRVAA
GEPLPLRQEQISFVGHAIEVRLCSEDAAQDFMPRSGRMALWQMPETVRVEHALESGTEIPPDYDSMIAKLISHGATREEA
RARLIVGLEQAVALGVVTNQWFLLSCLRHPAFAAGKATTAFIATHRDELRAPLIAAEDMALLAVLLSVSHPLAHPVRRGR
SLAATFATPLRFELGGELRECELSRDRDGSYCVTHNGAEQRSEIVTLDADTIRIRRGDVVDVVRFARDGDRLFVQSRGRT
LVLRDLTLGAPQSTAAAGGDGKVRAALNGRVVAMLVKAGDQVAAGQPVLTLEAMKMEHVHTAGLAGTVSAIAVAEGDQVT
TGQIVIEIKR

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=681, Percent_Identity=42.2907488986784, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI189095269, Length=674, Percent_Identity=40.0593471810089, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI65506442, Length=676, Percent_Identity=39.9408284023669, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI295821183, Length=662, Percent_Identity=39.4259818731118, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=46.4444444444444, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=46.4444444444444, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=46.4444444444444, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI38679974, Length=700, Percent_Identity=29.7142857142857, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38679977, Length=700, Percent_Identity=29.7142857142857, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38679967, Length=700, Percent_Identity=29.7142857142857, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38679971, Length=700, Percent_Identity=29.7142857142857, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI38679960, Length=700, Percent_Identity=29.7142857142857, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI134142062, Length=693, Percent_Identity=28.8600288600289, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1789654, Length=439, Percent_Identity=48.9749430523918, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786280, Length=201, Percent_Identity=27.363184079602, Blast_Score=63, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=665, Percent_Identity=42.7067669172932, Blast_Score=484, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17567343, Length=685, Percent_Identity=39.1240875912409, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562816, Length=450, Percent_Identity=46, Blast_Score=374, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=713, Percent_Identity=25.5259467040673, Blast_Score=213, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=706, Percent_Identity=24.3626062322946, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=467, Percent_Identity=28.4796573875803, Blast_Score=191, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=43.3707865168539, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=42.6008968609865, Blast_Score=330, Evalue=4e-91,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=43.4977578475336, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=698, Percent_Identity=28.6532951289398, Blast_Score=241, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6323863, Length=704, Percent_Identity=26.9886363636364, Blast_Score=239, Evalue=8e-64,
Organism=Drosophila melanogaster, GI24651757, Length=670, Percent_Identity=43.134328358209, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24651759, Length=629, Percent_Identity=41.81240063593, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24652212, Length=450, Percent_Identity=47.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652210, Length=450, Percent_Identity=47.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652214, Length=450, Percent_Identity=47.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19921944, Length=450, Percent_Identity=47.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652216, Length=450, Percent_Identity=47.1111111111111, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363050, Length=450, Percent_Identity=47.1111111111111, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652224, Length=450, Percent_Identity=47.1111111111111, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652222, Length=450, Percent_Identity=47.1111111111111, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652220, Length=450, Percent_Identity=47.1111111111111, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24652218, Length=450, Percent_Identity=47.1111111111111, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI161076409, Length=702, Percent_Identity=28.7749287749288, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI161076407, Length=702, Percent_Identity=28.7749287749288, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24586460, Length=702, Percent_Identity=28.7749287749288, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24586458, Length=702, Percent_Identity=28.7749287749288, Blast_Score=256, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 69757; Mature: 69626

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRPFHKVLIANRGEIALRVMRTARRLGYRVVAVYSDVDADAPHVRLADQAVRIGAPPP
CCCCCCCCEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEECCCEEECCCCCC
AQSYLNIAAIIAAAKATGADAVHPGYGFLAENEDFAQACKDAGLVFVGPSPDAIAAMGNK
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHCCEEEECCCCCHHHHCCCC
AGAKTIMQRAGVPCVPGYQGEDGGDEAMLREAKRIGFPVMIKAVAGGGGRGMRLVNEAYA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
FPDLLRSARSEAAAAFGDGTVILEKAIANPRHIEIQVFGDSHGNAVHLGERDCSVQRRHQ
HHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHH
KLIEEAPSPAVGPELRARMGAVAVQAVKALGYEGAGTLEFLLDGDGRFYFMEMNTRLQVE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCEEEEC
HPVTEALTGLDLVEWQLRVAAGEPLPLRQEQISFVGHAIEVRLCSEDAAQDFMPRSGRMA
CCHHHHHHCCHHEEEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCHHHHHCCCCCCCEE
LWQMPETVRVEHALESGTEIPPDYDSMIAKLISHGATREEARARLIVGLEQAVALGVVTN
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHEEEHHHHHEEHHHHC
QWFLLSCLRHPAFAAGKATTAFIATHRDELRAPLIAAEDMALLAVLLSVSHPLAHPVRRG
HHHHHHHHHCCCCCCCCCEEEEEEECHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHCC
RSLAATFATPLRFELGGELRECELSRDRDGSYCVTHNGAEQRSEIVTLDADTIRIRRGDV
CCEEEHHCCCEEEECCCCCEECCCCCCCCCCEEEECCCHHHCCCEEEEECCEEEEECCCH
VDVVRFARDGDRLFVQSRGRTLVLRDLTLGAPQSTAAAGGDGKVRAALNGRVVAMLVKAG
HHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCEEEEEEEECC
DQVAAGQPVLTLEAMKMEHVHTAGLAGTVSAIAVAEGDQVTTGQIVIEIKR
CCCCCCCCEEEEEHHHHHHHHHCCCHHHHHEEEEECCCCEEECEEEEEEEC
>Mature Secondary Structure 
SRRPFHKVLIANRGEIALRVMRTARRLGYRVVAVYSDVDADAPHVRLADQAVRIGAPPP
CCCCCCCEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEECCCEEECCCCCC
AQSYLNIAAIIAAAKATGADAVHPGYGFLAENEDFAQACKDAGLVFVGPSPDAIAAMGNK
HHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHCCEEEECCCCCHHHHCCCC
AGAKTIMQRAGVPCVPGYQGEDGGDEAMLREAKRIGFPVMIKAVAGGGGRGMRLVNEAYA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHH
FPDLLRSARSEAAAAFGDGTVILEKAIANPRHIEIQVFGDSHGNAVHLGERDCSVQRRHQ
HHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHH
KLIEEAPSPAVGPELRARMGAVAVQAVKALGYEGAGTLEFLLDGDGRFYFMEMNTRLQVE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECCEEEEC
HPVTEALTGLDLVEWQLRVAAGEPLPLRQEQISFVGHAIEVRLCSEDAAQDFMPRSGRMA
CCHHHHHHCCHHEEEEEEEECCCCCCCCHHHHHHHCCEEEEEECCCHHHHHCCCCCCCEE
LWQMPETVRVEHALESGTEIPPDYDSMIAKLISHGATREEARARLIVGLEQAVALGVVTN
EECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHEEEHHHHHEEHHHHC
QWFLLSCLRHPAFAAGKATTAFIATHRDELRAPLIAAEDMALLAVLLSVSHPLAHPVRRG
HHHHHHHHHCCCCCCCCCEEEEEEECHHHHCCCEEEHHHHHHHHHHHHHCCHHHHHHHCC
RSLAATFATPLRFELGGELRECELSRDRDGSYCVTHNGAEQRSEIVTLDADTIRIRRGDV
CCEEEHHCCCEEEECCCCCEECCCCCCCCCCEEEECCCHHHCCCEEEEECCEEEEECCCH
VDVVRFARDGDRLFVQSRGRTLVLRDLTLGAPQSTAAAGGDGKVRAALNGRVVAMLVKAG
HHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCEEEEEEEECC
DQVAAGQPVLTLEAMKMEHVHTAGLAGTVSAIAVAEGDQVTTGQIVIEIKR
CCCCCCCCEEEEEHHHHHHHHHCCCHHHHHEEEEECCCCEEECEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]