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The map label for this gene is baiB [H]

Identifier: 146343305

GI number: 146343305

Start: 6781120

End: 6782637

Strand: Direct

Name: baiB [H]

Synonym: BRADO6529

Alternate gene names: 146343305

Gene position: 6781120-6782637 (Clockwise)

Preceding gene: 146343304

Following gene: 146343306

Centisome position: 90.94

GC content: 67.19

Gene sequence:

>1518_bases
ATGCTGATCCCACTCGCGGACGTGCCGCGTTGGTACGCCGAGCGCAAGCCCAAAGACAGCATCGCGATCCAGCATGGAAC
CGACGCGCTCACCTGGGAGCAGCTCGAGCGCCGCGCCAATGCGCGCGCCCGCGCCTTTGCCGCGAAGGGCGTGAAGCCCG
GCGACTTCGTCGCGATCGGCCTGCCCAATGGCAACGAGCTGTTCGAGACCAGCTTTGCCGTCTGGAAATGCGGCGCCACG
CCGACGTCATTGTCGTGGCGGCTGCCGCGCGGCGAAGCCGCCGCGGTGCTCGAGATTCTCAAGCCCTCACTCGTCGTCGG
CGGCGAGGCCGATTGGAACGCGCCGAATGCGCTGCCCGCCGGCTTCACGCCCGAGGGTTTCTCGGACGAGCCGCTCACCG
GTCCGGTGTCGCGCTATTGGAAGGCGATGACGTCGGGCGGCTCGACGGGCCGGCCCAAGGTGATCCTCGATCATGCGCCA
GCGGTGACCGACACCGCAGCCGAACCGCCGCTCGGAATTCCCAAGGGCGCGGCGCTGCTCAATCCCGGGCCGCTGTATCA
CAACGCGCCCTTCATCGTATCGCATTACGCGCTGTTCGCCGGCGGCACCTTAACCGGCATGGTGAAGTTCGATGCCGAGG
AGACGCTGCGGCTGATCCAGGCGCAGCGCATCCAATGGGTGAATTTCGTGCCGACCATGATGCACCGGATCTGGGCGCTT
CCAGAGGCGGTACGCAACAGCTACGACCTGTCGAGCCTGAAAATGGTATTCCACATGGCGGCACCGATGCCGCCCTGGCT
GAAGGGGAAATGGATCGAGTGGCTCGGCCCGGAGCGCGTCTACGAGCTCTATGGCGGCACCGAGCGGCAGGGCCGCACCA
TCATTTCCGGCACCGAATGGCTTCAGCACAAAGGCTCGGTCGGCAAGATCGACGACGCGTGCAAACTGCGCATCCTCGGC
CCCGACGGCAATGACGTCGCGCCGGGCGAGAGTGGCGAGATCTACTTCCTGCCCGCCGACGGCCCGGGCAGCACCTATCA
CTATCTCGGCGCCGAGCCGAAGCGGCGCGCCGATGGCTGGGAGTCGCTCGGCGACATCGGCCGGCTCGATGCAGACGGTT
ATCTCTATCTCGGCGACCGCCTCGCCGACATGGTGCTGCGCGGTGGCGCCAACATTTATCCGGCCGAGGTCGAGGCGGCG
CTGATGGCGCATCCCGACATCCGCTCCTGTGTCGTGGTCGGCCTGCCCGATCCCGAGCTCGGCCAGCGGGTGCATGCGAT
CGTGGAGATCGATCGCGCCAAGGACGCGCAGGCGATCGTCGATGGCATGAGCGCGTTCCTCGCCGACCGGCTCTCGCGCT
ACAAGCACCCGGAGAGCTATGAGCTGGTCGACACGATGCTGCGCGATGATTCCGGGAAGGTCCGCCGCACGCTGCTGCGC
GACGAGCGCGCCATGTGGTTGAAGGAGGGTCGGGACTTCCGTCTGTTGCCGGCCCGCGCGCGCTCCCCGGCAGACTGA

Upstream 100 bases:

>100_bases
CATCGCGTTGAGGCACAACTCCCCTCGGCACTGATCCCGGCGGCACAAGCTGTTGGACCAAAAACGGCGCGCACAAGCGC
CTGACGATGCGGAGGACATG

Downstream 100 bases:

>100_bases
CGGGACGACAATTTTTCGAACGTTTACGATGCTGGCGTAGACTCCGAAAATGGGCAGGAGTGTTCGCGCCATGATTTCAC
GACGACGGTTTCTGCGCACC

Product: putative acyl-CoA ligase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MLIPLADVPRWYAERKPKDSIAIQHGTDALTWEQLERRANARARAFAAKGVKPGDFVAIGLPNGNELFETSFAVWKCGAT
PTSLSWRLPRGEAAAVLEILKPSLVVGGEADWNAPNALPAGFTPEGFSDEPLTGPVSRYWKAMTSGGSTGRPKVILDHAP
AVTDTAAEPPLGIPKGAALLNPGPLYHNAPFIVSHYALFAGGTLTGMVKFDAEETLRLIQAQRIQWVNFVPTMMHRIWAL
PEAVRNSYDLSSLKMVFHMAAPMPPWLKGKWIEWLGPERVYELYGGTERQGRTIISGTEWLQHKGSVGKIDDACKLRILG
PDGNDVAPGESGEIYFLPADGPGSTYHYLGAEPKRRADGWESLGDIGRLDADGYLYLGDRLADMVLRGGANIYPAEVEAA
LMAHPDIRSCVVVGLPDPELGQRVHAIVEIDRAKDAQAIVDGMSAFLADRLSRYKHPESYELVDTMLRDDSGKVRRTLLR
DERAMWLKEGRDFRLLPARARSPAD

Sequences:

>Translated_505_residues
MLIPLADVPRWYAERKPKDSIAIQHGTDALTWEQLERRANARARAFAAKGVKPGDFVAIGLPNGNELFETSFAVWKCGAT
PTSLSWRLPRGEAAAVLEILKPSLVVGGEADWNAPNALPAGFTPEGFSDEPLTGPVSRYWKAMTSGGSTGRPKVILDHAP
AVTDTAAEPPLGIPKGAALLNPGPLYHNAPFIVSHYALFAGGTLTGMVKFDAEETLRLIQAQRIQWVNFVPTMMHRIWAL
PEAVRNSYDLSSLKMVFHMAAPMPPWLKGKWIEWLGPERVYELYGGTERQGRTIISGTEWLQHKGSVGKIDDACKLRILG
PDGNDVAPGESGEIYFLPADGPGSTYHYLGAEPKRRADGWESLGDIGRLDADGYLYLGDRLADMVLRGGANIYPAEVEAA
LMAHPDIRSCVVVGLPDPELGQRVHAIVEIDRAKDAQAIVDGMSAFLADRLSRYKHPESYELVDTMLRDDSGKVRRTLLR
DERAMWLKEGRDFRLLPARARSPAD
>Mature_505_residues
MLIPLADVPRWYAERKPKDSIAIQHGTDALTWEQLERRANARARAFAAKGVKPGDFVAIGLPNGNELFETSFAVWKCGAT
PTSLSWRLPRGEAAAVLEILKPSLVVGGEADWNAPNALPAGFTPEGFSDEPLTGPVSRYWKAMTSGGSTGRPKVILDHAP
AVTDTAAEPPLGIPKGAALLNPGPLYHNAPFIVSHYALFAGGTLTGMVKFDAEETLRLIQAQRIQWVNFVPTMMHRIWAL
PEAVRNSYDLSSLKMVFHMAAPMPPWLKGKWIEWLGPERVYELYGGTERQGRTIISGTEWLQHKGSVGKIDDACKLRILG
PDGNDVAPGESGEIYFLPADGPGSTYHYLGAEPKRRADGWESLGDIGRLDADGYLYLGDRLADMVLRGGANIYPAEVEAA
LMAHPDIRSCVVVGLPDPELGQRVHAIVEIDRAKDAQAIVDGMSAFLADRLSRYKHPESYELVDTMLRDDSGKVRRTLLR
DERAMWLKEGRDFRLLPARARSPAD

Specific function: Active with a large number of C-24 bile acids possessing unhindered C-24 carboxyl groups. Requires ATP and produces AMP and pyrophosphate in addition to the bile-acid CoA thioester [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=361, Percent_Identity=28.2548476454294, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI42544132, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI38505220, Length=283, Percent_Identity=27.208480565371, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI122937307, Length=244, Percent_Identity=28.6885245901639, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI157311624, Length=292, Percent_Identity=27.3972602739726, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI157311622, Length=292, Percent_Identity=27.3972602739726, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI58082049, Length=305, Percent_Identity=27.2131147540984, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI115511026, Length=215, Percent_Identity=27.4418604651163, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI187761345, Length=407, Percent_Identity=24.5700245700246, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI187761343, Length=407, Percent_Identity=24.5700245700246, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=523, Percent_Identity=25.0478011472275, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788107, Length=528, Percent_Identity=23.8636363636364, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI221142682, Length=487, Percent_Identity=23.2032854209446, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790505, Length=361, Percent_Identity=21.8836565096953, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17559526, Length=530, Percent_Identity=27.5471698113208, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17531443, Length=521, Percent_Identity=23.8003838771593, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=480, Percent_Identity=25.625, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=518, Percent_Identity=24.9034749034749, Blast_Score=108, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=517, Percent_Identity=24.5647969052224, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=347, Percent_Identity=26.2247838616715, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=365, Percent_Identity=26.027397260274, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=365, Percent_Identity=26.027397260274, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=365, Percent_Identity=26.027397260274, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560140, Length=318, Percent_Identity=25.7861635220126, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=285, Percent_Identity=25.2631578947368, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=321, Percent_Identity=23.3644859813084, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=185, Percent_Identity=27.027027027027, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355181, Length=471, Percent_Identity=25.0530785562633, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24581924, Length=342, Percent_Identity=26.6081871345029, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358303, Length=440, Percent_Identity=24.3181818181818, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI18859661, Length=353, Percent_Identity=26.3456090651558, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24648253, Length=491, Percent_Identity=21.9959266802444, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24648255, Length=491, Percent_Identity=21.9959266802444, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356441, Length=487, Percent_Identity=20.9445585215606, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130357, Length=349, Percent_Identity=26.647564469914, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24656500, Length=495, Percent_Identity=24.040404040404, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281365686, Length=349, Percent_Identity=23.2091690544413, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356947, Length=174, Percent_Identity=28.1609195402299, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24653035, Length=480, Percent_Identity=20.625, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667959, Length=369, Percent_Identity=22.7642276422764, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667955, Length=369, Percent_Identity=22.7642276422764, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62472339, Length=369, Percent_Identity=22.7642276422764, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 55447; Mature: 55447

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIPLADVPRWYAERKPKDSIAIQHGTDALTWEQLERRANARARAFAAKGVKPGDFVAIG
CCCCCCCCCHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LPNGNELFETSFAVWKCGATPTSLSWRLPRGEAAAVLEILKPSLVVGGEADWNAPNALPA
CCCCCHHHHCCEEEEECCCCCCCCEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCC
GFTPEGFSDEPLTGPVSRYWKAMTSGGSTGRPKVILDHAPAVTDTAAEPPLGIPKGAALL
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
NPGPLYHNAPFIVSHYALFAGGTLTGMVKFDAEETLRLIQAQRIQWVNFVPTMMHRIWAL
CCCCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEAVRNSYDLSSLKMVFHMAAPMPPWLKGKWIEWLGPERVYELYGGTERQGRTIISGTEW
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCEEECCHHH
LQHKGSVGKIDDACKLRILGPDGNDVAPGESGEIYFLPADGPGSTYHYLGAEPKRRADGW
HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCHHHCCCH
ESLGDIGRLDADGYLYLGDRLADMVLRGGANIYPAEVEAALMAHPDIRSCVVVGLPDPEL
HHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHH
GQRVHAIVEIDRAKDAQAIVDGMSAFLADRLSRYKHPESYELVDTMLRDDSGKVRRTLLR
HHHHEEHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
DERAMWLKEGRDFRLLPARARSPAD
HHHHHHHHCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MLIPLADVPRWYAERKPKDSIAIQHGTDALTWEQLERRANARARAFAAKGVKPGDFVAIG
CCCCCCCCCHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LPNGNELFETSFAVWKCGATPTSLSWRLPRGEAAAVLEILKPSLVVGGEADWNAPNALPA
CCCCCHHHHCCEEEEECCCCCCCCEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCC
GFTPEGFSDEPLTGPVSRYWKAMTSGGSTGRPKVILDHAPAVTDTAAEPPLGIPKGAALL
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
NPGPLYHNAPFIVSHYALFAGGTLTGMVKFDAEETLRLIQAQRIQWVNFVPTMMHRIWAL
CCCCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PEAVRNSYDLSSLKMVFHMAAPMPPWLKGKWIEWLGPERVYELYGGTERQGRTIISGTEW
HHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCEEECCHHH
LQHKGSVGKIDDACKLRILGPDGNDVAPGESGEIYFLPADGPGSTYHYLGAEPKRRADGW
HHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCEEECCCCCHHHCCCH
ESLGDIGRLDADGYLYLGDRLADMVLRGGANIYPAEVEAALMAHPDIRSCVVVGLPDPEL
HHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHH
GQRVHAIVEIDRAKDAQAIVDGMSAFLADRLSRYKHPESYELVDTMLRDDSGKVRRTLLR
HHHHEEHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHH
DERAMWLKEGRDFRLLPARARSPAD
HHHHHHHHCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254270; 1551828 [H]