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The map label for this gene is shc [H]

Identifier: 146343060

GI number: 146343060

Start: 6496555

End: 6498609

Strand: Direct

Name: shc [H]

Synonym: BRADO6252

Alternate gene names: 146343060

Gene position: 6496555-6498609 (Clockwise)

Preceding gene: 146343059

Following gene: 146343063

Centisome position: 87.13

GC content: 68.18

Gene sequence:

>2055_bases
ATGACCTTGACCAGCTCGGCCTCCGCGCGCGCGCCGCGCGACCCGGGGAATTATCAGACCGCCTTGCAATCCACGGTCCG
AGCGGCCGCGGACTGGCTGATCGCAAACCAGAAGCCTGACGGGCACTGGGTCGGCCGCGCCGAATCCAACGCCTGCATGG
AGGCGCAATGGTGCCTCGCGCTGTGGTTCATGGGCCTCGAGGATCATCCGCTGCGCAAGCGCCTGGGCCAATCGCTGCTC
GACACCCAGCGCCCGGACGGCGCCTGGCAGGTCTATTTCAACGCGCCCAATGGCGACATCAATGCCACGGTCGAGGCCTA
TGCCGCGCTCCGCTCGCTGGGCTATCCGGACAGCGAGCCGGCGGTGCGCCGCGCGCGCGAGTGGATCGAGGCCAAGGGCG
GCCTGCGCAACATCCGGGTGTTCACCCGCTACTGGCTGGCGCTGATCGGCGAATGGCCGTGGGAGAAGACCCCGAACATC
CCCCCCGAGGTGATCTGGTTTCCGCTCTGGTTTCCGTTCTCGATCTACAATTTCGCACAATGGGCGCGCGCCACACTGAT
GCCGATCGCGCTGCTGTCGGCGCGGCGGCCGAGCCGGCCGCTGCCGCCGGAGAACCGGCTCGACACGCTGTTTCCGCGCG
GGCGCGACGCGTTCGACTACGAGCTGCCGGTGAAGGCCAATGCCGGCGGCTGGGACAAGTTCTTCCGCGGCGCCGACAAG
GTGCTGCATGCGCTGCAGAACTTCGGCAACAGGCTCAATCTCGGCCTGTTCCGCCCGGCCGCGACCAGCCGCGTGCTGGA
GTGGATGATCCGCCACCAGGATTTCGACGGCGCCTGGGGCGGCATCCAGCCGCCCTGGATCTACGGCCTGATGGCGCTCT
ACGCCGAGGGCTATCCGCTCAATCATCCCGTGCTCGCCAAGGGACTCGATGCGCTGAACGATCCCGGCTGGCGCGTCGAT
GTCGGCGAGGCCACCTATATCCAGGCGACCAACAGCCCGGTGTGGGACACGATCCTCACATTGCTCGCCTTCGACGATGC
CGGCGTGCTCGGCGACTATCCCGACGCGGTCGACAAGGCGGTGAACTGGGTGCTCGCGCGCCAGGTGCGCGTGCCCGGCG
ACTGGTCGATGAAGCTGCCGCACGTCAAGCCCGGCGGCTGGGCGTTCGAATACGCCAACAACCATTATCCCGACACGGAC
GACACCGCGGTGGCGCTGATCGCGCTGGCCCCGCTGCGCCATGATCCCAAATGGAAGGCCAAGGGCATCGACGAGGCGAT
TCAGCTCGGCGTCGACTGGCTGATCGGGATGCAGAGCCAGGGCGGCGGCTGGGGAGCGTTCGACAAGGACAACAACCAGC
AGATCCTGACCAAGATCCCATTCTGCGATTACGGCGAGGCGCTCGATCCGCCGTCGGTGGACGTCACCGCCCACATCGTC
GAGGCGTTCGGCAAGCTCGGCATCTCGCGCAACCATCCGTCGATGGTGCAGGCGCTCGATTATATCCGCAAAGAGCAGGA
GCCGAGCGGTCCGTGGTTCGGCCGCTGGGGCGTCAACTACGTCTACGGCACCGGCGCGGTGCTGCCGGCGCTGGCGGCGA
TCGGCGAAGACATGACCCAGCCCTATATCGGCCGCGCCTGCGACTGGCTGGTCGCCCACCAGCAGCCTGACGGCGGCTGG
GGCGAGAGCTGCGCCTCCTACATGGACATCTCGGCGGTCGGCCGCGGCACCACCACGGCGTCGCAGACGGCGTGGGCCCT
GATGGCCCTGCTCGCCGCCAACCGTCCCCAGGACAAGGACGCCATCGAGCGCGGCTGCATGTGGCTGGTCGAGCGCCAGT
CCGCCGGCACCTGGGACGAGCCGGAGTTCACCGGCACCGGCTTCCCGGGCTACGGCGTCGGCCAGACCATCAAGCTGACC
GATCCGTCGTTGCAGGAGCGCCTGATGCAGGGCCCGGAGCTCTCCCGCGCCTTCATGCTCCGCTACGGCATGTACCGCCA
CTACTTCCCGCTGATGGCGCTCGGCCGCGCGCTGCGGCCGCAGGGGCATGGTTAG

Upstream 100 bases:

>100_bases
CTGCTACAGCCAGTTGATTGGATTTGGCGGCGAAATTCCCTATAGGGCGGGGTGAATTCGACGGCTGTCGCGGCGCTGTC
AGGCCGCCAGAGGAATTGTG

Downstream 100 bases:

>100_bases
GCACTGTCGGCTCTCCGCCGTCCGGTACACTGCATCCCTCCCCTCGGTGTCGTCCCGGCCTTGAGCCGGGACCCATAACC
ACCGGCCTTGATGAGGTGGA

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MTLTSSASARAPRDPGNYQTALQSTVRAAADWLIANQKPDGHWVGRAESNACMEAQWCLALWFMGLEDHPLRKRLGQSLL
DTQRPDGAWQVYFNAPNGDINATVEAYAALRSLGYPDSEPAVRRAREWIEAKGGLRNIRVFTRYWLALIGEWPWEKTPNI
PPEVIWFPLWFPFSIYNFAQWARATLMPIALLSARRPSRPLPPENRLDTLFPRGRDAFDYELPVKANAGGWDKFFRGADK
VLHALQNFGNRLNLGLFRPAATSRVLEWMIRHQDFDGAWGGIQPPWIYGLMALYAEGYPLNHPVLAKGLDALNDPGWRVD
VGEATYIQATNSPVWDTILTLLAFDDAGVLGDYPDAVDKAVNWVLARQVRVPGDWSMKLPHVKPGGWAFEYANNHYPDTD
DTAVALIALAPLRHDPKWKAKGIDEAIQLGVDWLIGMQSQGGGWGAFDKDNNQQILTKIPFCDYGEALDPPSVDVTAHIV
EAFGKLGISRNHPSMVQALDYIRKEQEPSGPWFGRWGVNYVYGTGAVLPALAAIGEDMTQPYIGRACDWLVAHQQPDGGW
GESCASYMDISAVGRGTTTASQTAWALMALLAANRPQDKDAIERGCMWLVERQSAGTWDEPEFTGTGFPGYGVGQTIKLT
DPSLQERLMQGPELSRAFMLRYGMYRHYFPLMALGRALRPQGHG

Sequences:

>Translated_684_residues
MTLTSSASARAPRDPGNYQTALQSTVRAAADWLIANQKPDGHWVGRAESNACMEAQWCLALWFMGLEDHPLRKRLGQSLL
DTQRPDGAWQVYFNAPNGDINATVEAYAALRSLGYPDSEPAVRRAREWIEAKGGLRNIRVFTRYWLALIGEWPWEKTPNI
PPEVIWFPLWFPFSIYNFAQWARATLMPIALLSARRPSRPLPPENRLDTLFPRGRDAFDYELPVKANAGGWDKFFRGADK
VLHALQNFGNRLNLGLFRPAATSRVLEWMIRHQDFDGAWGGIQPPWIYGLMALYAEGYPLNHPVLAKGLDALNDPGWRVD
VGEATYIQATNSPVWDTILTLLAFDDAGVLGDYPDAVDKAVNWVLARQVRVPGDWSMKLPHVKPGGWAFEYANNHYPDTD
DTAVALIALAPLRHDPKWKAKGIDEAIQLGVDWLIGMQSQGGGWGAFDKDNNQQILTKIPFCDYGEALDPPSVDVTAHIV
EAFGKLGISRNHPSMVQALDYIRKEQEPSGPWFGRWGVNYVYGTGAVLPALAAIGEDMTQPYIGRACDWLVAHQQPDGGW
GESCASYMDISAVGRGTTTASQTAWALMALLAANRPQDKDAIERGCMWLVERQSAGTWDEPEFTGTGFPGYGVGQTIKLT
DPSLQERLMQGPELSRAFMLRYGMYRHYFPLMALGRALRPQGHG
>Mature_683_residues
TLTSSASARAPRDPGNYQTALQSTVRAAADWLIANQKPDGHWVGRAESNACMEAQWCLALWFMGLEDHPLRKRLGQSLLD
TQRPDGAWQVYFNAPNGDINATVEAYAALRSLGYPDSEPAVRRAREWIEAKGGLRNIRVFTRYWLALIGEWPWEKTPNIP
PEVIWFPLWFPFSIYNFAQWARATLMPIALLSARRPSRPLPPENRLDTLFPRGRDAFDYELPVKANAGGWDKFFRGADKV
LHALQNFGNRLNLGLFRPAATSRVLEWMIRHQDFDGAWGGIQPPWIYGLMALYAEGYPLNHPVLAKGLDALNDPGWRVDV
GEATYIQATNSPVWDTILTLLAFDDAGVLGDYPDAVDKAVNWVLARQVRVPGDWSMKLPHVKPGGWAFEYANNHYPDTDD
TAVALIALAPLRHDPKWKAKGIDEAIQLGVDWLIGMQSQGGGWGAFDKDNNQQILTKIPFCDYGEALDPPSVDVTAHIVE
AFGKLGISRNHPSMVQALDYIRKEQEPSGPWFGRWGVNYVYGTGAVLPALAAIGEDMTQPYIGRACDWLVAHQQPDGGWG
ESCASYMDISAVGRGTTTASQTAWALMALLAANRPQDKDAIERGCMWLVERQSAGTWDEPEFTGTGFPGYGVGQTIKLTD
PSLQERLMQGPELSRAFMLRYGMYRHYFPLMALGRALRPQGHG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=675, Percent_Identity=24.5925925925926, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI47933397, Length=675, Percent_Identity=24.5925925925926, Blast_Score=159, Evalue=8e-39,
Organism=Homo sapiens, GI224177558, Length=675, Percent_Identity=24.5925925925926, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI224177556, Length=603, Percent_Identity=25.0414593698176, Blast_Score=149, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321863, Length=646, Percent_Identity=23.5294117647059, Blast_Score=137, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 76267; Mature: 76136

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSSASARAPRDPGNYQTALQSTVRAAADWLIANQKPDGHWVGRAESNACMEAQWCLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHH
LWFMGLEDHPLRKRLGQSLLDTQRPDGAWQVYFNAPNGDINATVEAYAALRSLGYPDSEP
HHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCH
AVRRAREWIEAKGGLRNIRVFTRYWLALIGEWPWEKTPNIPPEVIWFPLWFPFSIYNFAQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
WARATLMPIALLSARRPSRPLPPENRLDTLFPRGRDAFDYELPVKANAGGWDKFFRGADK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEECCEECCCCCHHHHHHHHHH
VLHALQNFGNRLNLGLFRPAATSRVLEWMIRHQDFDGAWGGIQPPWIYGLMALYAEGYPL
HHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
NHPVLAKGLDALNDPGWRVDVGEATYIQATNSPVWDTILTLLAFDDAGVLGDYPDAVDKA
CCCHHHHHHHHHCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VNWVLARQVRVPGDWSMKLPHVKPGGWAFEYANNHYPDTDDTAVALIALAPLRHDPKWKA
HHHHHHHHEECCCCCCEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
KGIDEAIQLGVDWLIGMQSQGGGWGAFDKDNNQQILTKIPFCDYGEALDPPSVDVTAHIV
CCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH
EAFGKLGISRNHPSMVQALDYIRKEQEPSGPWFGRWGVNYVYGTGAVLPALAAIGEDMTQ
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
PYIGRACDWLVAHQQPDGGWGESCASYMDISAVGRGTTTASQTAWALMALLAANRPQDKD
CHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
AIERGCMWLVERQSAGTWDEPEFTGTGFPGYGVGQTIKLTDPSLQERLMQGPELSRAFML
HHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHH
RYGMYRHYFPLMALGRALRPQGHG
HHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLTSSASARAPRDPGNYQTALQSTVRAAADWLIANQKPDGHWVGRAESNACMEAQWCLA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHH
LWFMGLEDHPLRKRLGQSLLDTQRPDGAWQVYFNAPNGDINATVEAYAALRSLGYPDSEP
HHHCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCH
AVRRAREWIEAKGGLRNIRVFTRYWLALIGEWPWEKTPNIPPEVIWFPLWFPFSIYNFAQ
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHH
WARATLMPIALLSARRPSRPLPPENRLDTLFPRGRDAFDYELPVKANAGGWDKFFRGADK
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEECCEECCCCCHHHHHHHHHH
VLHALQNFGNRLNLGLFRPAATSRVLEWMIRHQDFDGAWGGIQPPWIYGLMALYAEGYPL
HHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCC
NHPVLAKGLDALNDPGWRVDVGEATYIQATNSPVWDTILTLLAFDDAGVLGDYPDAVDKA
CCCHHHHHHHHHCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHH
VNWVLARQVRVPGDWSMKLPHVKPGGWAFEYANNHYPDTDDTAVALIALAPLRHDPKWKA
HHHHHHHHEECCCCCCEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
KGIDEAIQLGVDWLIGMQSQGGGWGAFDKDNNQQILTKIPFCDYGEALDPPSVDVTAHIV
CCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHH
EAFGKLGISRNHPSMVQALDYIRKEQEPSGPWFGRWGVNYVYGTGAVLPALAAIGEDMTQ
HHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
PYIGRACDWLVAHQQPDGGWGESCASYMDISAVGRGTTTASQTAWALMALLAANRPQDKD
CHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHH
AIERGCMWLVERQSAGTWDEPEFTGTGFPGYGVGQTIKLTDPSLQERLMQGPELSRAFML
HHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHH
RYGMYRHYFPLMALGRALRPQGHG
HHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1729216; 9532806; 2253626; 9295270; 9931258 [H]