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The map label for this gene is garR [H]

Identifier: 146343006

GI number: 146343006

Start: 6419658

End: 6420554

Strand: Direct

Name: garR [H]

Synonym: BRADO6191

Alternate gene names: 146343006

Gene position: 6419658-6420554 (Clockwise)

Preceding gene: 146343005

Following gene: 146343007

Centisome position: 86.09

GC content: 72.02

Gene sequence:

>897_bases
ATGAGCAACATCACCTGCCTCGGCCTGGGCGCCATGGGCTCGCGCATGGCGGCCAGCCTGCTCAAGACAGGCCATCGCGT
CACGGTCTGGAATCGCTCGGCCGAGCGTGCCGCAGCGCTGGTCGCGGCCGGCGCCGTGGTGGCGGACACGCCGCGCGCGG
CCGTGCGCCAGGCCGATGTCGTGATGGCCATGACGCGCGACGACAACACGTCGCGCGAGATCTGGCTCGACCCGGCCACC
GGTGCGCTGGACGGCATGCGCGAGGGAGCGATCGCCGTCGAGAGCTCGACTCTGTCGCCCGCCTGGGTGCAGGATCTCGC
CCGCCACGCAGCCGCGCGCGCCATCCGCTTCGTCGATGCGCCCGTTGTCGGGTCGCGCCCTCAGGCCGATGCCGGTCAGC
TGATCTTCCTGGCGGGAGGCGACGCGGCAGACGTTGCGCTCGCCGCGCCCGTCCTGGAATGCATGGGCAGTGCCGTTCAC
CGCACCGGCCCGGTCGGCAGCGGCGCCCTGCTCAAGCTCGCCATCAACGCGCTGTTCGCCGTCCAGGTGACGGCCATGGC
CGAGCTGATCGGCGCGCTCGACGCCGCGGGCGCCGACATCGCGGGGGCCATCGAGATCATCGGCGCAACGCCGGTTGCGA
GCGCGGCGGCCAAAGGCGCCGCCAGCGCGATGCTGTCGGGCCGCTTCGCCCCGCTGTTTCCCGTCGAGCTCGTGGCCAAG
GATCTCGCTTATGTGCGCCAGCTCGGCACGCCGGTCGCTGCCGGCATGCCCATGACGACAGCCGCCGCCGGTGTGATGCA
ATCCGCCCTCGCGCACGGATTCGGCGGCGACAATCTCACCGGAATCGTCAGGCTGTTCAGGCCCGGGACGGCGCAGCCTT
CGGACACCCGCGCTTAG

Upstream 100 bases:

>100_bases
GTTGCCGGCGCCGTCGGCGCCCAGCAGCCCGCCTGACCGAACCGCAACCACGTCCCACCGTACGAGAGATCGACCACGAT
CGACCAACAAGGAATCGACG

Downstream 100 bases:

>100_bases
CGTTTTGAACCGACGGATGTCACGCATGGACCCGATCAGACGGCCGTCGAGACCACCAACGCGCGGATCCGCGCGATGAC
CCGGCACGACGTGGAGGACC

Product: putative 3-hydroxyisobutyrate dehydrogenase family protein

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSNITCLGLGAMGSRMAASLLKTGHRVTVWNRSAERAAALVAAGAVVADTPRAAVRQADVVMAMTRDDNTSREIWLDPAT
GALDGMREGAIAVESSTLSPAWVQDLARHAAARAIRFVDAPVVGSRPQADAGQLIFLAGGDAADVALAAPVLECMGSAVH
RTGPVGSGALLKLAINALFAVQVTAMAELIGALDAAGADIAGAIEIIGATPVASAAAKGAASAMLSGRFAPLFPVELVAK
DLAYVRQLGTPVAAGMPMTTAAAGVMQSALAHGFGGDNLTGIVRLFRPGTAQPSDTRA

Sequences:

>Translated_298_residues
MSNITCLGLGAMGSRMAASLLKTGHRVTVWNRSAERAAALVAAGAVVADTPRAAVRQADVVMAMTRDDNTSREIWLDPAT
GALDGMREGAIAVESSTLSPAWVQDLARHAAARAIRFVDAPVVGSRPQADAGQLIFLAGGDAADVALAAPVLECMGSAVH
RTGPVGSGALLKLAINALFAVQVTAMAELIGALDAAGADIAGAIEIIGATPVASAAAKGAASAMLSGRFAPLFPVELVAK
DLAYVRQLGTPVAAGMPMTTAAAGVMQSALAHGFGGDNLTGIVRLFRPGTAQPSDTRA
>Mature_297_residues
SNITCLGLGAMGSRMAASLLKTGHRVTVWNRSAERAAALVAAGAVVADTPRAAVRQADVVMAMTRDDNTSREIWLDPATG
ALDGMREGAIAVESSTLSPAWVQDLARHAAARAIRFVDAPVVGSRPQADAGQLIFLAGGDAADVALAAPVLECMGSAVHR
TGPVGSGALLKLAINALFAVQVTAMAELIGALDAAGADIAGAIEIIGATPVASAAAKGAASAMLSGRFAPLFPVELVAKD
LAYVRQLGTPVAAGMPMTTAAAGVMQSALAHGFGGDNLTGIVRLFRPGTAQPSDTRA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=30.8771929824561, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI23308751, Length=288, Percent_Identity=26.0416666666667, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI145693186, Length=269, Percent_Identity=30.8550185873606, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=30.3754266211604, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=267, Percent_Identity=26.9662921348315, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=24.8275862068966, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=260, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=29.7945205479452, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=29.7945205479452, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28574115, Length=269, Percent_Identity=27.5092936802974, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29986; Mature: 29855

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNITCLGLGAMGSRMAASLLKTGHRVTVWNRSAERAAALVAAGAVVADTPRAAVRQADV
CCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEECCCHHHHHHHHE
VMAMTRDDNTSREIWLDPATGALDGMREGAIAVESSTLSPAWVQDLARHAAARAIRFVDA
EEEEECCCCCCCEEEECCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
PVVGSRPQADAGQLIFLAGGDAADVALAAPVLECMGSAVHRTGPVGSGALLKLAINALFA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VQVTAMAELIGALDAAGADIAGAIEIIGATPVASAAAKGAASAMLSGRFAPLFPVELVAK
HHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DLAYVRQLGTPVAAGMPMTTAAAGVMQSALAHGFGGDNLTGIVRLFRPGTAQPSDTRA
HHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SNITCLGLGAMGSRMAASLLKTGHRVTVWNRSAERAAALVAAGAVVADTPRAAVRQADV
CCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEECCCHHHHHHHHE
VMAMTRDDNTSREIWLDPATGALDGMREGAIAVESSTLSPAWVQDLARHAAARAIRFVDA
EEEEECCCCCCCEEEECCCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
PVVGSRPQADAGQLIFLAGGDAADVALAAPVLECMGSAVHRTGPVGSGALLKLAINALFA
CCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
VQVTAMAELIGALDAAGADIAGAIEIIGATPVASAAAKGAASAMLSGRFAPLFPVELVAK
HHHHHHHHHHHHHHCCCCCHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DLAYVRQLGTPVAAGMPMTTAAAGVMQSALAHGFGGDNLTGIVRLFRPGTAQPSDTRA
HHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]