Click here to switch to the map view.

The map label for this gene is ethA [H]

Identifier: 146342608

GI number: 146342608

Start: 5974070

End: 5975557

Strand: Direct

Name: ethA [H]

Synonym: BRADO5772

Alternate gene names: 146342608

Gene position: 5974070-5975557 (Clockwise)

Preceding gene: 146342607

Following gene: 146342609

Centisome position: 80.12

GC content: 65.26

Gene sequence:

>1488_bases
ATGATCAGCCGTAAAAATGTCTGCGTCATCGGCGCCGGCGTGTCCGGCCTTGCCGCCGCCAAAGCCTTCGCCGCCCGCGG
CCACAACGTCACCATCATCGAGCGCAGCGCCGATCTCGGCGGTGTATGGGAGCCCGCCCGTTCCTATCCCGACGTGCAGA
CGCAAAGCCCGAAGGATCTCTATCGCTACACCGACAAGGCGATGCCCGAGAGCTATCCGGAGTGGCCGAAGGGACCACAG
GTCTATGCGTATCTCTCCGACTACGCGAGATCCCACGATCTCACGCGCCTGATGCGGCTGAACACGACGGTGAGGTTGAT
GCAGCGGCGCGCGGATGGCAAGCCTGGCTGGACGCTCGATCTCATGTCCGGCGAGAGCGAGAGCCGCGAGGACTACGATT
TCGTGGCCGTATGCACCGGACAGTTCAACGAGCCGCAGACGCTCTCGCTTCCAGGCGAGGATGCGTTCAAGGCGGCCGGT
GGTGCGATCATGCACTCATCGAAATACAACGACGCCGGCATCGCGCGGGGCCGCAACGTCGTCGTGCTCGGCGGCTCGAA
ATCGGCGACCGACCTTGCCGTCAACGCGGTTCGGTCCGGCGCGCGCTCGGTGACCATCGTGTTACGAGAGCCGGTGTGGC
GCATCCCCTACTTCATCGGCGGGCTGATCAACTTCAAGCGCATCCTCTACATCCGTGCGCAGGAGCAGATGTTCGCGAGC
TGGGGCATCGGGCCGCTTTCGCGGCTTGCGCATCTGCTCGCCAAGCCGCTGGTCTGGGCGAATTGGCGCGGCCTGGAGAG
CCTGCTCAAGACGCAGCTCAAGCTTGCCAAATGCAACATGGTGCCCAAGGAGCGGATCGAGGACGGCGTCAACTGCTCGG
TGCCGATCGCGACACCCGACTTCTACCCGATGGTCTCCGACGGCCGTATCAAGGCGGTGCTCGGTACCTTCGATCACTAC
GAGCCGAACACGATCGTGGCCAGCACCGGCGAGCGGATCGCGGCCGACGTCGCGGTGCTCGCGATCGGCTACAAGCTCGG
CGTCCCCTTTCTGTCCGAGACCGACCGCGCAAGGCTGGTCGATCCCGACGGGCAGTACCGCCTGTACCGGCTGATCGCCA
ATCCCGACCTTCCCGAGATGGGTTTCGTCGGCTTCAACTCCAGCTTCTGCACCGTGCTCTGCGCGGACATGGCCGCGCAT
TGGCTGGTGCGCTACGCCGACAGGCAGCTCGCGCACCAGCCCAGCGAGCGTGAGATGCGCGACAACATCGAGATGATGCT
GCACTTCAAGCGCGTCGAGCGGCCGGCGGCGGGCGTGTATGGCGGACTCTGCGTGGCGCCCTATCACTTCAAGCATTTCG
ACGAGCTGCTCGCCGATATCGGCGCGACGCGGCGGCGGCGCAGTCCGCTTGCCGAGATGTTCACGCCGCCGGATGCCGAC
GCCTATGCCGGCTATCTCGCGTCGGCACCGGCCTACCAGGCTGGCTGA

Upstream 100 bases:

>100_bases
CGGGCGACCTCGTCATCACCCGTTCTTTCAGCGAGCCCCTGCAGCGCGGCCGGTCCAGGCTGTCCGCTTGCGGTCGCACG
CTCGATATCAGGAGGTCTCC

Downstream 100 bases:

>100_bases
TCCGTCACGGGGCAGCCCCAGGACGGACCAAATCATGCCGCATCGAAGGCGGCTTTGAGCGTCGTGCCGGCAGCGGGCGT
CGCGTTTCCGGCCGCTCAGT

Product: putative dimethylaniline monooxygenase (N-oxide-forming) exported protein

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MISRKNVCVIGAGVSGLAAAKAFAARGHNVTIIERSADLGGVWEPARSYPDVQTQSPKDLYRYTDKAMPESYPEWPKGPQ
VYAYLSDYARSHDLTRLMRLNTTVRLMQRRADGKPGWTLDLMSGESESREDYDFVAVCTGQFNEPQTLSLPGEDAFKAAG
GAIMHSSKYNDAGIARGRNVVVLGGSKSATDLAVNAVRSGARSVTIVLREPVWRIPYFIGGLINFKRILYIRAQEQMFAS
WGIGPLSRLAHLLAKPLVWANWRGLESLLKTQLKLAKCNMVPKERIEDGVNCSVPIATPDFYPMVSDGRIKAVLGTFDHY
EPNTIVASTGERIAADVAVLAIGYKLGVPFLSETDRARLVDPDGQYRLYRLIANPDLPEMGFVGFNSSFCTVLCADMAAH
WLVRYADRQLAHQPSEREMRDNIEMMLHFKRVERPAAGVYGGLCVAPYHFKHFDELLADIGATRRRRSPLAEMFTPPDAD
AYAGYLASAPAYQAG

Sequences:

>Translated_495_residues
MISRKNVCVIGAGVSGLAAAKAFAARGHNVTIIERSADLGGVWEPARSYPDVQTQSPKDLYRYTDKAMPESYPEWPKGPQ
VYAYLSDYARSHDLTRLMRLNTTVRLMQRRADGKPGWTLDLMSGESESREDYDFVAVCTGQFNEPQTLSLPGEDAFKAAG
GAIMHSSKYNDAGIARGRNVVVLGGSKSATDLAVNAVRSGARSVTIVLREPVWRIPYFIGGLINFKRILYIRAQEQMFAS
WGIGPLSRLAHLLAKPLVWANWRGLESLLKTQLKLAKCNMVPKERIEDGVNCSVPIATPDFYPMVSDGRIKAVLGTFDHY
EPNTIVASTGERIAADVAVLAIGYKLGVPFLSETDRARLVDPDGQYRLYRLIANPDLPEMGFVGFNSSFCTVLCADMAAH
WLVRYADRQLAHQPSEREMRDNIEMMLHFKRVERPAAGVYGGLCVAPYHFKHFDELLADIGATRRRRSPLAEMFTPPDAD
AYAGYLASAPAYQAG
>Mature_495_residues
MISRKNVCVIGAGVSGLAAAKAFAARGHNVTIIERSADLGGVWEPARSYPDVQTQSPKDLYRYTDKAMPESYPEWPKGPQ
VYAYLSDYARSHDLTRLMRLNTTVRLMQRRADGKPGWTLDLMSGESESREDYDFVAVCTGQFNEPQTLSLPGEDAFKAAG
GAIMHSSKYNDAGIARGRNVVVLGGSKSATDLAVNAVRSGARSVTIVLREPVWRIPYFIGGLINFKRILYIRAQEQMFAS
WGIGPLSRLAHLLAKPLVWANWRGLESLLKTQLKLAKCNMVPKERIEDGVNCSVPIATPDFYPMVSDGRIKAVLGTFDHY
EPNTIVASTGERIAADVAVLAIGYKLGVPFLSETDRARLVDPDGQYRLYRLIANPDLPEMGFVGFNSSFCTVLCADMAAH
WLVRYADRQLAHQPSEREMRDNIEMMLHFKRVERPAAGVYGGLCVAPYHFKHFDELLADIGATRRRRSPLAEMFTPPDAD
AYAGYLASAPAYQAG

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503755, Length=482, Percent_Identity=27.8008298755187, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4503757, Length=479, Percent_Identity=25.8872651356994, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI4503759, Length=455, Percent_Identity=24.6153846153846, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI221316672, Length=441, Percent_Identity=25.8503401360544, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI221316674, Length=441, Percent_Identity=25.8503401360544, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI221316678, Length=225, Percent_Identity=30.2222222222222, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI50541965, Length=475, Percent_Identity=22.3157894736842, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI50541961, Length=475, Percent_Identity=22.3157894736842, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25145785, Length=428, Percent_Identity=24.5327102803738, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193202226, Length=219, Percent_Identity=26.027397260274, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17541300, Length=351, Percent_Identity=25.9259259259259, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17555726, Length=447, Percent_Identity=24.6085011185682, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25150462, Length=222, Percent_Identity=27.4774774774775, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561948, Length=227, Percent_Identity=28.6343612334802, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506045, Length=216, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922866, Length=217, Percent_Identity=26.7281105990783, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921694, Length=217, Percent_Identity=30.4147465437788, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 54764; Mature: 54764

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRKNVCVIGAGVSGLAAAKAFAARGHNVTIIERSADLGGVWEPARSYPDVQTQSPKDL
CCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHH
YRYTDKAMPESYPEWPKGPQVYAYLSDYARSHDLTRLMRLNTTVRLMQRRADGKPGWTLD
HHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LMSGESESREDYDFVAVCTGQFNEPQTLSLPGEDAFKAAGGAIMHSSKYNDAGIARGRNV
EECCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHCCCEEEECCCCCCCHHCCCCEE
VVLGGSKSATDLAVNAVRSGARSVTIVLREPVWRIPYFIGGLINFKRILYIRAQEQMFAS
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEHHHHHHH
WGIGPLSRLAHLLAKPLVWANWRGLESLLKTQLKLAKCNMVPKERIEDGVNCSVPIATPD
CCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCC
FYPMVSDGRIKAVLGTFDHYEPNTIVASTGERIAADVAVLAIGYKLGVPFLSETDRARLV
CCCEECCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
DPDGQYRLYRLIANPDLPEMGFVGFNSSFCTVLCADMAAHWLVRYADRQLAHQPSEREMR
CCCCCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DNIEMMLHFKRVERPAAGVYGGLCVAPYHFKHFDELLADIGATRRRRSPLAEMFTPPDAD
HHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
AYAGYLASAPAYQAG
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MISRKNVCVIGAGVSGLAAAKAFAARGHNVTIIERSADLGGVWEPARSYPDVQTQSPKDL
CCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCHHHH
YRYTDKAMPESYPEWPKGPQVYAYLSDYARSHDLTRLMRLNTTVRLMQRRADGKPGWTLD
HHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LMSGESESREDYDFVAVCTGQFNEPQTLSLPGEDAFKAAGGAIMHSSKYNDAGIARGRNV
EECCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHCCCEEEECCCCCCCHHCCCCEE
VVLGGSKSATDLAVNAVRSGARSVTIVLREPVWRIPYFIGGLINFKRILYIRAQEQMFAS
EEECCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEHHHHHHH
WGIGPLSRLAHLLAKPLVWANWRGLESLLKTQLKLAKCNMVPKERIEDGVNCSVPIATPD
CCCCHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCC
FYPMVSDGRIKAVLGTFDHYEPNTIVASTGERIAADVAVLAIGYKLGVPFLSETDRARLV
CCCEECCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
DPDGQYRLYRLIANPDLPEMGFVGFNSSFCTVLCADMAAHWLVRYADRQLAHQPSEREMR
CCCCCEEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
DNIEMMLHFKRVERPAAGVYGGLCVAPYHFKHFDELLADIGATRRRRSPLAEMFTPPDAD
HHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
AYAGYLASAPAYQAG
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA