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The map label for this gene is ilvC [H]

Identifier: 146342401

GI number: 146342401

Start: 5744690

End: 5745709

Strand: Reverse

Name: ilvC [H]

Synonym: BRADO5559

Alternate gene names: 146342401

Gene position: 5745709-5744690 (Counterclockwise)

Preceding gene: 146342402

Following gene: 146342399

Centisome position: 77.06

GC content: 64.31

Gene sequence:

>1020_bases
ATGCGTGTCTACTACGATCGCGACGCCGATCTGAACCTGATCAAGGGCAAGAAGGTCGTCATCGTCGGCTACGGCAGCCA
GGGCCATGCCCATGCGCTGAACCTGAAGGACTCTGGCGTCAAGGACGTCGCGATCGCGCTGCGCAAGGGCTCGGCCTCGG
CCAAGAAGGCCGAAGGCGCCGGCTTCAAGGTGATGGAAGTCGCCGAGGCCGCCAAGTGGGCCGACCTCGTGATGATGCTG
ACCCCGGACGAGCTGCAGGGCGACATCTACCGCGAGCACCTGCACGACAACATGAAGCAGGGCGCCGCGCTGGTGTTCGC
GCACGGCCTCAACGTGCATTTCAATCTTCTTGATCCCCGGGCAGATCTCGACGTGCTGATGATCGCGCCGAAGGGCCCCG
GCCACACCGTCCGCTCCGAATACCAGCGCGGCGGCGGCGTGCCCTGCCTGATCGCGATCGCCAAGGATTCCTCGGGCAAT
GCCCATGACCTCGGCCTGTCCTACGCCTCGGCGATCGGCGGCGGCCGCGCTGGCATCATCGAGACCACCTTCAAGGAAGA
GTGCGAGACCGACCTGTTCGGCGAGCAGGCGGTGCTGTGCGGCGGCCTGGTCGAGCTGATCAAGGCCGGATACGAGACCC
TGACCGAGGCCGGCTACGCGCCGGAGATGGCCTATTTCGAGTGCCTCCACGAGGTGAAGCTGATCGTCGACCTGATCTAT
GAAGGCGGCATCGCCAACATGAACTACTCGATCTCCAACACCGCCGAATATGGCGAGTACGTCACCGGCCCGCGCATCAT
CACCCCCGAGACCAAGGCCGAGATGAAGCGTGTGCTCGACGACATCCAGTCCGGCCGCTTCGCCCGCGACTGGATGCTCG
AGAACAAGGTCAACCAGTCCTCGTTCAAGGCCACCCGCGCCCGCCTGTCGCAGCACCCGATCGAGGAAGTCGGCGCCCGC
CTGCGCGACATGATGCCCTGGATCAAGAAGGGCGCGCTGGTCGATAAGAGCAAGAACTAA

Upstream 100 bases:

>100_bases
TCTAGACACGGGCCGGATTTCGTCCGGGCGCAGCCGCCCGTGCCTCACCCAAGCGTCTGACTTTTCAGCCAATTCCGGCA
TCTCTCAAGAGGAAACGACA

Downstream 100 bases:

>100_bases
GGGGTGTGATCAGCGGTCGGGACGCGGATCCGCGTTCTCGGCCATCAGCTCAATCGAAAGCCTCCGTCCCGGCCAGGGCG
GAGGCTTTTTACGGCCACAG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLKDSGVKDVAIALRKGSASAKKAEGAGFKVMEVAEAAKWADLVMML
TPDELQGDIYREHLHDNMKQGAALVFAHGLNVHFNLLDPRADLDVLMIAPKGPGHTVRSEYQRGGGVPCLIAIAKDSSGN
AHDLGLSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGYETLTEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLDDIQSGRFARDWMLENKVNQSSFKATRARLSQHPIEEVGAR
LRDMMPWIKKGALVDKSKN

Sequences:

>Translated_339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLKDSGVKDVAIALRKGSASAKKAEGAGFKVMEVAEAAKWADLVMML
TPDELQGDIYREHLHDNMKQGAALVFAHGLNVHFNLLDPRADLDVLMIAPKGPGHTVRSEYQRGGGVPCLIAIAKDSSGN
AHDLGLSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGYETLTEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLDDIQSGRFARDWMLENKVNQSSFKATRARLSQHPIEEVGAR
LRDMMPWIKKGALVDKSKN
>Mature_339_residues
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLKDSGVKDVAIALRKGSASAKKAEGAGFKVMEVAEAAKWADLVMML
TPDELQGDIYREHLHDNMKQGAALVFAHGLNVHFNLLDPRADLDVLMIAPKGPGHTVRSEYQRGGGVPCLIAIAKDSSGN
AHDLGLSYASAIGGGRAGIIETTFKEECETDLFGEQAVLCGGLVELIKAGYETLTEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLDDIQSGRFARDWMLENKVNQSSFKATRARLSQHPIEEVGAR
LRDMMPWIKKGALVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=39.8671096345515, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6323387, Length=265, Percent_Identity=35.0943396226415, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37047; Mature: 37047

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLKDSGVKDVAIALRKGSASAKKAEGA
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCHHEEEEEECCCCCCCCCCCC
GFKVMEVAEAAKWADLVMMLTPDELQGDIYREHLHDNMKQGAALVFAHGLNVHFNLLDPR
CCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCC
ADLDVLMIAPKGPGHTVRSEYQRGGGVPCLIAIAKDSSGNAHDLGLSYASAIGGGRAGII
CCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIKAGYETLTEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLDDIQSGRFARDWMLENKVNQS
CCCCCCCCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
SFKATRARLSQHPIEEVGARLRDMMPWIKKGALVDKSKN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRVYYDRDADLNLIKGKKVVIVGYGSQGHAHALNLKDSGVKDVAIALRKGSASAKKAEGA
CEEEECCCCCCEEECCCEEEEEEECCCCCEEEECCCCCCCHHEEEEEECCCCCCCCCCCC
GFKVMEVAEAAKWADLVMMLTPDELQGDIYREHLHDNMKQGAALVFAHGLNVHFNLLDPR
CCHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEEEECCC
ADLDVLMIAPKGPGHTVRSEYQRGGGVPCLIAIAKDSSGNAHDLGLSYASAIGGGRAGII
CCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEE
ETTFKEECETDLFGEQAVLCGGLVELIKAGYETLTEAGYAPEMAYFECLHEVKLIVDLIY
ECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVTGPRIITPETKAEMKRVLDDIQSGRFARDWMLENKVNQS
CCCCCCCCCCCCCCHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCHH
SFKATRARLSQHPIEEVGARLRDMMPWIKKGALVDKSKN
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]