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The map label for this gene is adhC [H]

Identifier: 146342331

GI number: 146342331

Start: 5667957

End: 5669066

Strand: Direct

Name: adhC [H]

Synonym: BRADO5486

Alternate gene names: 146342331

Gene position: 5667957-5669066 (Clockwise)

Preceding gene: 146342330

Following gene: 146342332

Centisome position: 76.01

GC content: 64.05

Gene sequence:

>1110_bases
ATGAAGACGCGCGCCGCGGTCGCTTTCGAAGCCAAGAAACCGCTGGAGATCGTCGAGGTCGACCTCGAGGGACCGAAGGC
CGGCGAGGTTCTGGTCGAGATCAAGGCGACCGGCATCTGCCACACCGATGCGTACACGCTCGACGGCTTCGACAGCGAGG
GCATCTTCCCCTCGATCCTCGGCCATGAGGGCGCCGGTATCGTGCGTGAGATCGGGCCTGGCGTCACCTCGGTCAAGCCA
GGCGACCACGTCATTCCGCTGTACACACCGGAATGCCGCCAGTGCAAGAGCTGCCTCAGCCGCAAGACCAATCTCTGCAC
CGCGATCCGCGCCACCCAAGGCAAGGGCCTGATGCCGGACGGCACCTCGCGCTTCAGCTATAAGGGCCAGACCATCTACC
ACTACATGGGCTGCTCGACCTTCGCCAACCATACCGTGCTGCCGGAGATCGCGGTCGCCAAGATCCGCGAGGACGCGCCG
TTCGACAAGAGCTGCTACATCGGCTGCGGTGTCACCACCGGCGTCGGCGCGGTCGTGAATACGGCGAAGGTCACGCCCGG
CGCGAATGTCGTCATCTTCGGCCTCGGCGGCATCGGCCTGAACGTGATTCAGGGCGCCCGGATGGCGGGAGCCGACAAGA
TCATCGGCGTCGACATCAACGACAGCAAAGAGGAATGGGGCCGCCGCTTCGGCATGACCCACTTCGTCAATCCGAAGAAG
GTGACCGGCGACATCGTCCAGCACCTCGTCGCGCTCACCGATGGCGGCGCCGACTACACCTTCGACTGCACCGGCAACAC
CACCGTCATGCGCCAGGCGCTCGAAGCCTGCCATCGCGGCTGGGGCGAATCGATCATCATCGGTGTCGCCGAGGCCGGCA
AGGAAATCGCGACCCGTCCATTCCAGCTCGTCACCGGACGGGTCTGGAAGGGCACCGCGTTCGGCGGCGCGCGCGGGCGC
ACCGACGTTCCCAAGATCGTCGACTGGTACATGAACGGGAAGATCGAAATCGACCCGATGATCACCCACACGCTCAAGCT
CGAAGACATCAACAAGGGCTTCGACCTGATGCATGAGGGCAAGTCGATCCGTTCCGTCGTCGTGTTCTGA

Upstream 100 bases:

>100_bases
TACGGAAGCGGAAAACTCCTGCATGGGCAAGAAATGACCGACGAAGGCCGCGCTCTGGGCAGGGCCGCGGCCTTGAGAGA
CTGAAACAGGAGTTTGAGAC

Downstream 100 bases:

>100_bases
CCCGAGCCACGCAAAACCGAGGAGGATTGCGCCATGACTGTCCACATTCATCCGTCCGTCGACCATGGAGTGAAACAAGG
GAGCGGCCACTTCGCGGGCG

Product: S-(hydroxymethyl)glutathione dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKTRAAVAFEAKKPLEIVEVDLEGPKAGEVLVEIKATGICHTDAYTLDGFDSEGIFPSILGHEGAGIVREIGPGVTSVKP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRATQGKGLMPDGTSRFSYKGQTIYHYMGCSTFANHTVLPEIAVAKIREDAP
FDKSCYIGCGVTTGVGAVVNTAKVTPGANVVIFGLGGIGLNVIQGARMAGADKIIGVDINDSKEEWGRRFGMTHFVNPKK
VTGDIVQHLVALTDGGADYTFDCTGNTTVMRQALEACHRGWGESIIIGVAEAGKEIATRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMNGKIEIDPMITHTLKLEDINKGFDLMHEGKSIRSVVVF

Sequences:

>Translated_369_residues
MKTRAAVAFEAKKPLEIVEVDLEGPKAGEVLVEIKATGICHTDAYTLDGFDSEGIFPSILGHEGAGIVREIGPGVTSVKP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRATQGKGLMPDGTSRFSYKGQTIYHYMGCSTFANHTVLPEIAVAKIREDAP
FDKSCYIGCGVTTGVGAVVNTAKVTPGANVVIFGLGGIGLNVIQGARMAGADKIIGVDINDSKEEWGRRFGMTHFVNPKK
VTGDIVQHLVALTDGGADYTFDCTGNTTVMRQALEACHRGWGESIIIGVAEAGKEIATRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMNGKIEIDPMITHTLKLEDINKGFDLMHEGKSIRSVVVF
>Mature_369_residues
MKTRAAVAFEAKKPLEIVEVDLEGPKAGEVLVEIKATGICHTDAYTLDGFDSEGIFPSILGHEGAGIVREIGPGVTSVKP
GDHVIPLYTPECRQCKSCLSRKTNLCTAIRATQGKGLMPDGTSRFSYKGQTIYHYMGCSTFANHTVLPEIAVAKIREDAP
FDKSCYIGCGVTTGVGAVVNTAKVTPGANVVIFGLGGIGLNVIQGARMAGADKIIGVDINDSKEEWGRRFGMTHFVNPKK
VTGDIVQHLVALTDGGADYTFDCTGNTTVMRQALEACHRGWGESIIIGVAEAGKEIATRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMNGKIEIDPMITHTLKLEDINKGFDLMHEGKSIRSVVVF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=60.4904632152589, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=46.9168900804289, Blast_Score=359, Evalue=2e-99,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=45.5284552845528, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=45.945945945946, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=45.945945945946, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=45.2574525745258, Blast_Score=340, Evalue=9e-94,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=44.9864498644986, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=43.6314363143631, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.0443213296399, Blast_Score=329, Evalue=2e-90,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=61.5176151761518, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1788073, Length=365, Percent_Identity=26.8493150684932, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=26.5582655826558, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=25.5874673629243, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1787863, Length=360, Percent_Identity=23.3333333333333, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081918, Length=344, Percent_Identity=29.0697674418605, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=365, Percent_Identity=25.7534246575342, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786825, Length=369, Percent_Identity=23.5772357723577, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786518, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=55.4959785522788, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=55.2, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=55.3935860058309, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562584, Length=371, Percent_Identity=31.266846361186, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=27.4932614555256, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562582, Length=372, Percent_Identity=27.9569892473118, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=56.6037735849057, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6323099, Length=386, Percent_Identity=29.0155440414508, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=28.9693593314763, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=28.9693593314763, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=26.7567567567568, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=25.5376344086022, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=26.7379679144385, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=276, Percent_Identity=26.4492753623188, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=374, Percent_Identity=24.0641711229947, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=362, Percent_Identity=24.0331491712707, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=58.1521739130435, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=26.9230769230769, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=24.188790560472, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39619; Mature: 39619

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVAFEAKKPLEIVEVDLEGPKAGEVLVEIKATGICHTDAYTLDGFDSEGIFPSIL
CCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVREIGPGVTSVKPGDHVIPLYTPECRQCKSCLSRKTNLCTAIRATQGKGLMPD
CCCCCCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GTSRFSYKGQTIYHYMGCSTFANHTVLPEIAVAKIREDAPFDKSCYIGCGVTTGVGAVVN
CCCCEEECCCEEEEEECCHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCHHCCHHHEE
TAKVTPGANVVIFGLGGIGLNVIQGARMAGADKIIGVDINDSKEEWGRRFGMTHFVNPKK
CEEECCCCCEEEEEECCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCCEECCCHH
VTGDIVQHLVALTDGGADYTFDCTGNTTVMRQALEACHRGWGESIIIGVAEAGKEIATRP
HHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCCC
FQLVTGRVWKGTAFGGARGRTDVPKIVDWYMNGKIEIDPMITHTLKLEDINKGFDLMHEG
EEHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCEEEECCEEEEEEEEECCCCCHHHHHCC
KSIRSVVVF
CCCEEEEEC
>Mature Secondary Structure
MKTRAAVAFEAKKPLEIVEVDLEGPKAGEVLVEIKATGICHTDAYTLDGFDSEGIFPSIL
CCCCEEEEEECCCCEEEEEEECCCCCCCCEEEEEEECEEEECCCEEECCCCCCCCCHHHH
GHEGAGIVREIGPGVTSVKPGDHVIPLYTPECRQCKSCLSRKTNLCTAIRATQGKGLMPD
CCCCCCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
GTSRFSYKGQTIYHYMGCSTFANHTVLPEIAVAKIREDAPFDKSCYIGCGVTTGVGAVVN
CCCCEEECCCEEEEEECCHHHCCCCCCCHHHHHHHHCCCCCCCCEEEECCCHHCCHHHEE
TAKVTPGANVVIFGLGGIGLNVIQGARMAGADKIIGVDINDSKEEWGRRFGMTHFVNPKK
CEEECCCCCEEEEEECCCCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHCCCCEECCCHH
VTGDIVQHLVALTDGGADYTFDCTGNTTVMRQALEACHRGWGESIIIGVAEAGKEIATRP
HHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCCC
FQLVTGRVWKGTAFGGARGRTDVPKIVDWYMNGKIEIDPMITHTLKLEDINKGFDLMHEG
EEHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCEEEECCEEEEEEEEECCCCCHHHHHCC
KSIRSVVVF
CCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]