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The map label for this gene is fghA [H]

Identifier: 146342305

GI number: 146342305

Start: 5645421

End: 5646266

Strand: Direct

Name: fghA [H]

Synonym: BRADO5460

Alternate gene names: 146342305

Gene position: 5645421-5646266 (Clockwise)

Preceding gene: 146342304

Following gene: 146342307

Centisome position: 75.71

GC content: 67.02

Gene sequence:

>846_bases
ATGACGCTCACGACCGTGTCCCAGAACAAATCCCACGGCGGCGTTCAGGGCGTCTATGGCCATGCCAGCCAGGAGACCAA
GACCGAGATGACGTTCTCGGTGTTTGTGCCGCCGCATGCGGACGGCGCGAAGCTGCCGGTCGTCTGGTATCTCTCCGGCC
TGACCTGCACCCACGCCAATGTCACCGAGAAGGGCGAGTTCCGTGCCGCCTGCGCCGAGCTCGGCCTGATCTTCGTCGCG
CCCGACACCTCGCCGCGTGGCGACGGCGTGCCGGGCGATCCGAACAACGCCTATGATTTCGGCCTCGGCGCCGGCTTCTA
CGTCGATGCGACGCAGGAGCCGTTTGCGAAGAACTATCGGATGTGGAGCTACGTCACGGAGGAGCTGCCGCACGTGGTCG
CCGCGAATTTCCCGGTCGATCCGCGCCGGCAATCGGTGATGGGCCATTCGATGGGCGGCCATGGCGCGCTGACGGTGGCG
CTGCGCAACCCCGACCGCTACCGCGCGGCCAGCGCGTTCTCGCCGATCGTCGCCCCCTCGCAGGTGCCATGGGGCGAGAA
GGCGCTGTCAGGCTATCTCGGCAGCGACAAGGCGGCATGGCGCAAGCACGACGCGGTGGCGCTGATCGAGGATGGCGCGC
GCGTCTCCGACCTGCTGGTCGATATCGGCACCGCCGATCAGTTCCTGACGCAGCAATTGCGCCCCGAGCTGCTCAAGGCC
GCCTGCGACAAGGCCAACATCCCGCTGCTGCTGCGCAAGCAGGACGGCTACGACCACAGCTACTACTTCATCTCGACCTA
CATGGCCGATCATCTGCGCTGGCACGCGGCCCGGCTCGGCCGCTGA

Upstream 100 bases:

>100_bases
CGAGCTCGTGCGTTTGGCGATCGAGAACGGCGTCGCTTGACATCGGGCCGGCGGCGCGCTCCGTTCCGCCGCCCCATGTT
CCTTTTCGACAGGTGATCCC

Downstream 100 bases:

>100_bases
CATCGGCTCGGCTTGAGTTGCCCGTCGGGCGCGATGCCGTGCGACGGGCGGCGCGGCGATCGCGTTCCTCGTCGGACCGT
TGCTTGCGCGTAGATGGCCA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTLTTVSQNKSHGGVQGVYGHASQETKTEMTFSVFVPPHADGAKLPVVWYLSGLTCTHANVTEKGEFRAACAELGLIFVA
PDTSPRGDGVPGDPNNAYDFGLGAGFYVDATQEPFAKNYRMWSYVTEELPHVVAANFPVDPRRQSVMGHSMGGHGALTVA
LRNPDRYRAASAFSPIVAPSQVPWGEKALSGYLGSDKAAWRKHDAVALIEDGARVSDLLVDIGTADQFLTQQLRPELLKA
ACDKANIPLLLRKQDGYDHSYYFISTYMADHLRWHAARLGR

Sequences:

>Translated_281_residues
MTLTTVSQNKSHGGVQGVYGHASQETKTEMTFSVFVPPHADGAKLPVVWYLSGLTCTHANVTEKGEFRAACAELGLIFVA
PDTSPRGDGVPGDPNNAYDFGLGAGFYVDATQEPFAKNYRMWSYVTEELPHVVAANFPVDPRRQSVMGHSMGGHGALTVA
LRNPDRYRAASAFSPIVAPSQVPWGEKALSGYLGSDKAAWRKHDAVALIEDGARVSDLLVDIGTADQFLTQQLRPELLKA
ACDKANIPLLLRKQDGYDHSYYFISTYMADHLRWHAARLGR
>Mature_280_residues
TLTTVSQNKSHGGVQGVYGHASQETKTEMTFSVFVPPHADGAKLPVVWYLSGLTCTHANVTEKGEFRAACAELGLIFVAP
DTSPRGDGVPGDPNNAYDFGLGAGFYVDATQEPFAKNYRMWSYVTEELPHVVAANFPVDPRRQSVMGHSMGGHGALTVAL
RNPDRYRAASAFSPIVAPSQVPWGEKALSGYLGSDKAAWRKHDAVALIEDGARVSDLLVDIGTADQFLTQQLRPELLKAA
CDKANIPLLLRKQDGYDHSYYFISTYMADHLRWHAARLGR

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=282, Percent_Identity=51.7730496453901, Blast_Score=315, Evalue=2e-86,
Organism=Escherichia coli, GI1786551, Length=278, Percent_Identity=47.4820143884892, Blast_Score=278, Evalue=2e-76,
Organism=Escherichia coli, GI1788477, Length=279, Percent_Identity=47.3118279569892, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17510185, Length=285, Percent_Identity=50.5263157894737, Blast_Score=276, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=40.7407407407407, Blast_Score=232, Evalue=4e-62,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=50.530035335689, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=50.530035335689, Blast_Score=277, Evalue=5e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30667; Mature: 30536

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTTVSQNKSHGGVQGVYGHASQETKTEMTFSVFVPPHADGAKLPVVWYLSGLTCTHAN
CEEEEECCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCEEEECCC
VTEKGEFRAACAELGLIFVAPDTSPRGDGVPGDPNNAYDFGLGAGFYVDATQEPFAKNYR
CCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCHHHHCCH
MWSYVTEELPHVVAANFPVDPRRQSVMGHSMGGHGALTVALRNPDRYRAASAFSPIVAPS
HHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCC
QVPWGEKALSGYLGSDKAAWRKHDAVALIEDGARVSDLLVDIGTADQFLTQQLRPELLKA
CCCCCHHHHHCCCCCCCHHHHCCCCEEEEECCCCHHHHEEECCCHHHHHHHHHHHHHHHH
ACDKANIPLLLRKQDGYDHSYYFISTYMADHLRWHAARLGR
HCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLTTVSQNKSHGGVQGVYGHASQETKTEMTFSVFVPPHADGAKLPVVWYLSGLTCTHAN
EEEEECCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCEEEEEECCEEEECCC
VTEKGEFRAACAELGLIFVAPDTSPRGDGVPGDPNNAYDFGLGAGFYVDATQEPFAKNYR
CCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCHHHHCCH
MWSYVTEELPHVVAANFPVDPRRQSVMGHSMGGHGALTVALRNPDRYRAASAFSPIVAPS
HHHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCC
QVPWGEKALSGYLGSDKAAWRKHDAVALIEDGARVSDLLVDIGTADQFLTQQLRPELLKA
CCCCCHHHHHCCCCCCCHHHHCCCCEEEEECCCCHHHHEEECCCHHHHHHHHHHHHHHHH
ACDKANIPLLLRKQDGYDHSYYFISTYMADHLRWHAARLGR
HCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]