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The map label for this gene is degU [H]

Identifier: 146342304

GI number: 146342304

Start: 5644740

End: 5645360

Strand: Direct

Name: degU [H]

Synonym: BRADO5459

Alternate gene names: 146342304

Gene position: 5644740-5645360 (Clockwise)

Preceding gene: 146342299

Following gene: 146342305

Centisome position: 75.7

GC content: 66.51

Gene sequence:

>621_bases
ATGCGCATCCTGATCGTCGATGATCATCCCATTGTTGCATCCGGCTGCCGGGCCCTGCTGTCGGGCGATGCGGACCTCGA
GCTGATCGAGGCCGCCGATGCCGAGAGCGGCGAAGCGAGCTTCATCGCGCGCCGGCCCGACGTCTGCGTCGTCGACATCA
ACCTGCCGACCGTCTCCGGATTCGAGCTGGCGCGCCGCATCCTCGCGCATGACGCGAACGCCCGGCTGATCATGTTCAGC
ATGAACGACGATCCGGTGTTCGCCGCGCGCGCGATCGACATCGGCGCCAAGGGCTATGTCTCGAAGAGCGGCGATCCGAA
CGACCTGGCCGAGGCGATCCGCGAGGTCTTCAGCGGCGGCAGCTACCTGCCGCCGGCGATCGCGCGCAGCATCGCCTTCG
CGGGCGCCGCCGTCGCGCAGAGCCCATTGGCGAAACTGACCTCGCGCGAACTCGAGATCCTGCGCCTGCTCAGCGCCGGC
AAGAGCCTGACGGAGATCGCCTGGCTGATCCATTCGTCCTACAAGACCGTGGCCAACACCTCCTCCATCATCCGCCAGAA
GCTCGGCGTAAGAACGTCCGGCGAGCTCGTGCGTTTGGCGATCGAGAACGGCGTCGCTTGA

Upstream 100 bases:

>100_bases
CAACATGTTGCAGCACCGCGCAGCCCATGCATCCATGATGCATCGCAACAATAACGCGGGTTGAAAATGAGTCCGGGACC
CCCAAGGTGACCTCAAGGCC

Downstream 100 bases:

>100_bases
CATCGGGCCGGCGGCGCGCTCCGTTCCGCCGCCCCATGTTCCTTTTCGACAGGTGATCCCATGACGCTCACGACCGTGTC
CCAGAACAAATCCCACGGCG

Product: two-component LuxR family response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRILIVDDHPIVASGCRALLSGDADLELIEAADAESGEASFIARRPDVCVVDINLPTVSGFELARRILAHDANARLIMFS
MNDDPVFAARAIDIGAKGYVSKSGDPNDLAEAIREVFSGGSYLPPAIARSIAFAGAAVAQSPLAKLTSRELEILRLLSAG
KSLTEIAWLIHSSYKTVANTSSIIRQKLGVRTSGELVRLAIENGVA

Sequences:

>Translated_206_residues
MRILIVDDHPIVASGCRALLSGDADLELIEAADAESGEASFIARRPDVCVVDINLPTVSGFELARRILAHDANARLIMFS
MNDDPVFAARAIDIGAKGYVSKSGDPNDLAEAIREVFSGGSYLPPAIARSIAFAGAAVAQSPLAKLTSRELEILRLLSAG
KSLTEIAWLIHSSYKTVANTSSIIRQKLGVRTSGELVRLAIENGVA
>Mature_206_residues
MRILIVDDHPIVASGCRALLSGDADLELIEAADAESGEASFIARRPDVCVVDINLPTVSGFELARRILAHDANARLIMFS
MNDDPVFAARAIDIGAKGYVSKSGDPNDLAEAIREVFSGGSYLPPAIARSIAFAGAAVAQSPLAKLTSRELEILRLLSAG
KSLTEIAWLIHSSYKTVANTSSIIRQKLGVRTSGELVRLAIENGVA

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=32.1608040201005, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=30.8056872037915, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790102, Length=197, Percent_Identity=35.0253807106599, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=27.4038461538462, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=35.1219512195122, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=28.1407035175879, Blast_Score=81, Evalue=4e-17,
Organism=Escherichia coli, GI1787473, Length=163, Percent_Identity=30.0613496932515, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21841; Mature: 21841

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILIVDDHPIVASGCRALLSGDADLELIEAADAESGEASFIARRPDVCVVDINLPTVSG
CEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCH
FELARRILAHDANARLIMFSMNDDPVFAARAIDIGAKGYVSKSGDPNDLAEAIREVFSGG
HHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
SYLPPAIARSIAFAGAAVAQSPLAKLTSRELEILRLLSAGKSLTEIAWLIHSSYKTVANT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SSIIRQKLGVRTSGELVRLAIENGVA
HHHHHHHHCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MRILIVDDHPIVASGCRALLSGDADLELIEAADAESGEASFIARRPDVCVVDINLPTVSG
CEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCH
FELARRILAHDANARLIMFSMNDDPVFAARAIDIGAKGYVSKSGDPNDLAEAIREVFSGG
HHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCC
SYLPPAIARSIAFAGAAVAQSPLAKLTSRELEILRLLSAGKSLTEIAWLIHSSYKTVANT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
SSIIRQKLGVRTSGELVRLAIENGVA
HHHHHHHHCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]