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The map label for this gene is ahpC [H]

Identifier: 146342224

GI number: 146342224

Start: 5582592

End: 5583146

Strand: Direct

Name: ahpC [H]

Synonym: BRADO5376

Alternate gene names: 146342224

Gene position: 5582592-5583146 (Clockwise)

Preceding gene: 146342217

Following gene: 146342225

Centisome position: 74.87

GC content: 62.88

Gene sequence:

>555_bases
ATGCTCGGAATTGGAAGTAAGCTGCCGTCGTTCGAAATCGTCGGTGTGAAGCCTGGTTTTCATCTGCAGGAGGAGAAGGG
CGAGAGCGCCTTCGAGACCCTGACCGAAGCCAGCTTTCCCGGAAAGTGGAAGATCATCTTCTTCTATCCGAAGGACTTCA
CCTTCGTCTGCCCGACCGAGATCGCGGAGTTCGCGCGGCTGTCGAAGGACTTTGCCGACCGCGACGCGGTCGTGCTCGGC
GGCTCCACCGACAACGAGTTCTGCAAGCTGGCCTGGCGTCGCGACCACAAGGATCTGCACAAGCTGCCGATCTGGCAGTT
CGCCGACACAAAGGGCTCCCTGGTCGACGGCCTCGGCGTGCGCTCGCCGGATGGCGTCGCCTACCGCTATACGTTCATCG
TCGATCCGGACAACACCATCCAGCACGTCTACGCGACCAACCTCAATGTCGGCCGCGCGCCGAAGGACACGCTGCGCGTG
CTCGACGCGCTGCAGACCGACGAGCTCTGCCCGTGCAACCGCGAGGTCGGCGGCGAGACCCTGAAGGTCGCTTGA

Upstream 100 bases:

>100_bases
GCTTTCCCGACAACGCATTGATGTTGATAGCTAATGGCATATCGCTTGCAATGCACAATGCGCCTCGCTATTGCAGCGCA
GAAATTTCTTGGAGTGCGAC

Downstream 100 bases:

>100_bases
TCATGTCGATCGAGCAGCTCAAGGACCAGATTCCGGACTTCGCCAAGGACGTCCGGCTCAACCTGTCGTCGATGGCGTCC
GACGAGACGCTGTCGCCGCA

Product: thioredoxin peroxidase AhpC

Products: NA

Alternate protein names: MtAhpC; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MLGIGSKLPSFEIVGVKPGFHLQEEKGESAFETLTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLSKDFADRDAVVLG
GSTDNEFCKLAWRRDHKDLHKLPIWQFADTKGSLVDGLGVRSPDGVAYRYTFIVDPDNTIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKVA

Sequences:

>Translated_184_residues
MLGIGSKLPSFEIVGVKPGFHLQEEKGESAFETLTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLSKDFADRDAVVLG
GSTDNEFCKLAWRRDHKDLHKLPIWQFADTKGSLVDGLGVRSPDGVAYRYTFIVDPDNTIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKVA
>Mature_184_residues
MLGIGSKLPSFEIVGVKPGFHLQEEKGESAFETLTEASFPGKWKIIFFYPKDFTFVCPTEIAEFARLSKDFADRDAVVLG
GSTDNEFCKLAWRRDHKDLHKLPIWQFADTKGSLVDGLGVRSPDGVAYRYTFIVDPDNTIQHVYATNLNVGRAPKDTLRV
LDALQTDELCPCNREVGGETLKVA

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=187, Percent_Identity=33.6898395721925, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI32455266, Length=187, Percent_Identity=33.6898395721925, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI32455264, Length=187, Percent_Identity=33.6898395721925, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI32189392, Length=187, Percent_Identity=36.3636363636364, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI32483377, Length=160, Percent_Identity=36.875, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI5802974, Length=160, Percent_Identity=36.875, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI5453549, Length=162, Percent_Identity=34.5679012345679, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI33188454, Length=89, Percent_Identity=40.4494382022472, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1786822, Length=172, Percent_Identity=34.3023255813954, Blast_Score=97, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=35.8288770053476, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=35.8288770053476, Blast_Score=110, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17554494, Length=189, Percent_Identity=34.3915343915344, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323613, Length=163, Percent_Identity=38.6503067484663, Blast_Score=101, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320661, Length=160, Percent_Identity=37.5, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319407, Length=137, Percent_Identity=32.8467153284672, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17157991, Length=160, Percent_Identity=35.625, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24641739, Length=160, Percent_Identity=35.625, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17738015, Length=154, Percent_Identity=35.0649350649351, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=30.5263157894737, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656348, Length=156, Percent_Identity=33.974358974359, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17864676, Length=156, Percent_Identity=33.974358974359, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20544; Mature: 20544

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIGSKLPSFEIVGVKPGFHLQEEKGESAFETLTEASFPGKWKIIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IAEFARLSKDFADRDAVVLGGSTDNEFCKLAWRRDHKDLHKLPIWQFADTKGSLVDGLGV
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCEEECCCCCCEECCCCC
RSPDGVAYRYTFIVDPDNTIQHVYATNLNVGRAPKDTLRVLDALQTDELCPCNREVGGET
CCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
LKVA
EEEC
>Mature Secondary Structure
MLGIGSKLPSFEIVGVKPGFHLQEEKGESAFETLTEASFPGKWKIIFFYPKDFTFVCPTE
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IAEFARLSKDFADRDAVVLGGSTDNEFCKLAWRRDHKDLHKLPIWQFADTKGSLVDGLGV
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHCCCEEECCCCCCEECCCCC
RSPDGVAYRYTFIVDPDNTIQHVYATNLNVGRAPKDTLRVLDALQTDELCPCNREVGGET
CCCCCEEEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
LKVA
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604044; 8596438; 9634230; 12218036 [H]