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The map label for this gene is bioH [H]

Identifier: 146341757

GI number: 146341757

Start: 5076700

End: 5077485

Strand: Direct

Name: bioH [H]

Synonym: BRADO4874

Alternate gene names: 146341757

Gene position: 5076700-5077485 (Clockwise)

Preceding gene: 146341756

Following gene: 146341758

Centisome position: 68.08

GC content: 67.3

Gene sequence:

>786_bases
ATGCAGCTGTCGATTGCTGATCGCGATGTGTTCGTGGCGACCGGCGGTCGCGCGTTCGATTCATCCCTGCCCGCTGCCGT
CTTCGTGCACGGCGCCGGCTTCGATCATTCGGTCTGGGCGTTGCACAGCCGCTGGTTCGCGCATCACGGCTTTGCCGTGC
TGGCGCCCGACCTGCCCGGCCATGGCCGTTCCGGAGGGCCGGCGCTGCCGACAATCTCCGCGATGGCCGACTGGATCGTC
GCGCTGTTGCGGGCGGTGGACGCGAAGCCCGCACATCTCATCGGCCATTCAATGGGGTCGCTGATCGCGCTCGACACCGC
GGCGCGCCATCCGGATCACGTTTCTGCGCTGAGCCTGATCGGCACCGCCGCAACGATGACCGTCGGGCCGGATCTCCTGA
AAGCCGCGGAAGCCAATGATCACACCGCGATCGACATGGTCTCGATCTGGGGTCTCGGTTTTGCAGCCGAGCTCGGCGGC
AGCCGCGCGCCCGGCCTGTGGATGCATGGCGGCGCCCAAGCGACGCTGGAGCGCTGCGCGCCGGGCGTGCTATTCAATGA
TCTCTCCGCCTGCAACAACTATCAGGATGCGCTGGCATCGGCGGCCCGGATCAAGGTGCCGACGCGGCTGATCCTCGGCG
AGAAGGACATGATGACGCCGCTGAGGGCCGGCAAGGCGCTGGCCGCGGCGATCGCGCAATCCCGCGTGATCGTGCTGCCC
GGCGCCGGCCATACGATGATGGCTGAGTATCCGGACGCGCTGCTCGATGCGCTCATTGCCAGTTGA

Upstream 100 bases:

>100_bases
CGGCGAAGAGCTGATCCGGCTGTCGGTAGGCATCGAGGCCGCATCTGATATCATCGATGATCTCGGACAGGCGCTGCGCG
CCTCGCAGAAGGTGTGAGCC

Downstream 100 bases:

>100_bases
TGCGAGGACACTGTTGTTCCGCGCGGATCCGGTGACGGCGCGGCGTTTGCGCAGGCCGCGATTAGGAACGTCGCGTGACG
CGCCCCATTGGTGGTTGGTG

Product: putative alpha/beta hydrolase fold-containing protein

Products: NA

Alternate protein names: Biotin synthesis protein BioH [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MQLSIADRDVFVATGGRAFDSSLPAAVFVHGAGFDHSVWALHSRWFAHHGFAVLAPDLPGHGRSGGPALPTISAMADWIV
ALLRAVDAKPAHLIGHSMGSLIALDTAARHPDHVSALSLIGTAATMTVGPDLLKAAEANDHTAIDMVSIWGLGFAAELGG
SRAPGLWMHGGAQATLERCAPGVLFNDLSACNNYQDALASAARIKVPTRLILGEKDMMTPLRAGKALAAAIAQSRVIVLP
GAGHTMMAEYPDALLDALIAS

Sequences:

>Translated_261_residues
MQLSIADRDVFVATGGRAFDSSLPAAVFVHGAGFDHSVWALHSRWFAHHGFAVLAPDLPGHGRSGGPALPTISAMADWIV
ALLRAVDAKPAHLIGHSMGSLIALDTAARHPDHVSALSLIGTAATMTVGPDLLKAAEANDHTAIDMVSIWGLGFAAELGG
SRAPGLWMHGGAQATLERCAPGVLFNDLSACNNYQDALASAARIKVPTRLILGEKDMMTPLRAGKALAAAIAQSRVIVLP
GAGHTMMAEYPDALLDALIAS
>Mature_261_residues
MQLSIADRDVFVATGGRAFDSSLPAAVFVHGAGFDHSVWALHSRWFAHHGFAVLAPDLPGHGRSGGPALPTISAMADWIV
ALLRAVDAKPAHLIGHSMGSLIALDTAARHPDHVSALSLIGTAATMTVGPDLLKAAEANDHTAIDMVSIWGLGFAAELGG
SRAPGLWMHGGAQATLERCAPGVLFNDLSACNNYQDALASAARIKVPTRLILGEKDMMTPLRAGKALAAAIAQSRVIVLP
GAGHTMMAEYPDALLDALIAS

Specific function: Shows carboxylesterase activity with a preference for short chain fatty acid esters (acyl chain length of up to 6 carbons). Also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR010076 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 27054; Mature: 27054

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSIADRDVFVATGGRAFDSSLPAAVFVHGAGFDHSVWALHSRWFAHHGFAVLAPDLPG
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCC
HGRSGGPALPTISAMADWIVALLRAVDAKPAHLIGHSMGSLIALDTAARHPDHVSALSLI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEHHHCCCCCHHHHHHHH
GTAATMTVGPDLLKAAEANDHTAIDMVSIWGLGFAAELGGSRAPGLWMHGGAQATLERCA
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCEEEECCHHHHHHHCC
PGVLFNDLSACNNYQDALASAARIKVPTRLILGEKDMMTPLRAGKALAAAIAQSRVIVLP
CCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCHHHHCHHHHHHHHHHHHHHCCEEEEC
GAGHTMMAEYPDALLDALIAS
CCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLSIADRDVFVATGGRAFDSSLPAAVFVHGAGFDHSVWALHSRWFAHHGFAVLAPDLPG
CCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCCC
HGRSGGPALPTISAMADWIVALLRAVDAKPAHLIGHSMGSLIALDTAARHPDHVSALSLI
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEHHHCCCCCHHHHHHHH
GTAATMTVGPDLLKAAEANDHTAIDMVSIWGLGFAAELGGSRAPGLWMHGGAQATLERCA
HHHHHHHCCHHHHHHCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCEEEECCHHHHHHHCC
PGVLFNDLSACNNYQDALASAARIKVPTRLILGEKDMMTPLRAGKALAAAIAQSRVIVLP
CCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCHHHHCHHHHHHHHHHHHHHCCEEEEC
GAGHTMMAEYPDALLDALIAS
CCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]