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The map label for this gene is ndhL [H]

Identifier: 146341670

GI number: 146341670

Start: 4967814

End: 4969385

Strand: Reverse

Name: ndhL [H]

Synonym: BRADO4775

Alternate gene names: 146341670

Gene position: 4969385-4967814 (Counterclockwise)

Preceding gene: 146341671

Following gene: 146341669

Centisome position: 66.64

GC content: 66.6

Gene sequence:

>1572_bases
ATGCTGGAACTGCGCAAGGACATCTTCGCCGACGAGCGCGACGACAATCTCAACGAGGTCGGCAAGGGCACGCAGCGGCA
GGACATGCTGGGCCACGTCACGGGCACCTCGACCTATTTCAACGACCACAAGCTGCAGGGCATGCTGCATCTGCGGGTCG
TCAGATCCACACAGCCGCATGCAAGGCTGCGCCGCATCGATACCAGCGAGGCCGAGCGAAGCGAAGGCGTCCGACGGATC
ATCCGCGGCGCTGATGTGCCGCGCAATCTGAACACGCTGCTCAGCCTGATCAATTTCGGCAAGGACGACGAGCCGACGCT
GGCGGTCGACAAGGTGCGCTATCGCGGCGAGCCGATCGTGGCCGTCGTTGCCGAGACGCCGCGCCTCGCCGCCGAGGCGG
CGGCCAAGGTGCGCGTGGACTATGAGACCTTGCCGGCGGTATTCGACGTCGAGGAGGCGCTGAAGCCGGGCGCGCCGACG
GTCAATGAGACCTATCCGAAGAACACGTTCACCTATCACGAGCGCTACGACCATCAGAAGCTGCGCTTCGGCGACGTCGA
GCGCGGTTTTGCCCAGGCCGACCATGTGCTGGAGCAGCGCTACCAGATGTCGCCGATCGAGCATGCGCCGGTCGAGACCA
ACGGCTCGATCGCCGCGCCCGATACGAACGGCCGCTACGTGGTCTACACCTCGACGCAGGCGCTGTTCTTCTCGCTCGAT
ACCTGCGCCAAGATCCTCGATCTGCCGTCCAACACGTTCCACTTCATCGGCGGCACCGTCGGCGGCGGCTTCGGTGGCAA
GGTCGACACCTTGACCGAGCCGCTCGCGATCCTCGCGGCGATGCTGACCGGGCGGCCGGTGCGTTACGTGTTCGGGCGCG
AGGAGGAGATGCAGTTCGGGCCGCCGCGCGGCGCCGAGCGCATCTACATCAAGGACGGCGTGATGCGCGACGGCCGCATC
GTCGCGCGGCAGATCCGCGGCTATTTCGACTCCGGCGCGTACACGCGGCTGTCGAGCTATGCCGTCGTCAAATGCGCGGC
GCATCTCCCCGGGCCCTATACGATCCCGAACGTCCATGGCGATATCTACTGCGTCTTCACCAACCGGACGCCGGCCACCG
CGATGCGCGGCTTCGGTATCACCGGCATGGACTTCGCGCTCGAATGCCAGATGGACAAGCTCGCGCATCTCATCGGCATG
GACCCCATGGAGTTCCGAATCCTGAACGCGTATCGCGACGGCGACATGAAGGCGCATCGCCGCGAGGCCAAGAACACGGC
GTTGATCGAATGCGTGCAGGTCGCGGCCGAGAAGGCGAAATGGCCGATCCGCGAGGAGTTTCGCCGGATGTCGTCACGCA
GGGATGGTGGCGGCGCGCGGGCGGCGGTGCCGTCCACGCCGCGGGAGCCTGCGCAACCGCGCTCTGTACCGGCGCAGCAG
CGCACCAGCTACGATCGCGGGCTTCCGATCTCGCCACAGCCCGAACCGCCGCCACCACCGCCGCCTTCGGCGCCATCGTC
GGGGCACGGCGCCACCCGGTTCTCATCCGTGTTCGGCACGAGGAGGCGCTGA

Upstream 100 bases:

>100_bases
CGATCTCCGGCAACATCTGCCGCTGCACCGGCTACGAGCCGATCATCAACGCGGTGCTGGCCGCGGCGGCGTCGCGCGCG
AGCGCTTGAGGGAAATCGTC

Downstream 100 bases:

>100_bases
GATGACGAGGCACCGCGGCCGCGGCATGGCGGCGATCAACTATCCCATCGGCATGAATCTCGGCGGCGATCCGAGCCAGG
CACTGGTGCATTCGAACCCG

Product: putative oxidoreductase subunit aerobic-type carbon monoxide dehydrogenase large subunit CoxL/CutL

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MLELRKDIFADERDDNLNEVGKGTQRQDMLGHVTGTSTYFNDHKLQGMLHLRVVRSTQPHARLRRIDTSEAERSEGVRRI
IRGADVPRNLNTLLSLINFGKDDEPTLAVDKVRYRGEPIVAVVAETPRLAAEAAAKVRVDYETLPAVFDVEEALKPGAPT
VNETYPKNTFTYHERYDHQKLRFGDVERGFAQADHVLEQRYQMSPIEHAPVETNGSIAAPDTNGRYVVYTSTQALFFSLD
TCAKILDLPSNTFHFIGGTVGGGFGGKVDTLTEPLAILAAMLTGRPVRYVFGREEEMQFGPPRGAERIYIKDGVMRDGRI
VARQIRGYFDSGAYTRLSSYAVVKCAAHLPGPYTIPNVHGDIYCVFTNRTPATAMRGFGITGMDFALECQMDKLAHLIGM
DPMEFRILNAYRDGDMKAHRREAKNTALIECVQVAAEKAKWPIREEFRRMSSRRDGGGARAAVPSTPREPAQPRSVPAQQ
RTSYDRGLPISPQPEPPPPPPPSAPSSGHGATRFSSVFGTRRR

Sequences:

>Translated_523_residues
MLELRKDIFADERDDNLNEVGKGTQRQDMLGHVTGTSTYFNDHKLQGMLHLRVVRSTQPHARLRRIDTSEAERSEGVRRI
IRGADVPRNLNTLLSLINFGKDDEPTLAVDKVRYRGEPIVAVVAETPRLAAEAAAKVRVDYETLPAVFDVEEALKPGAPT
VNETYPKNTFTYHERYDHQKLRFGDVERGFAQADHVLEQRYQMSPIEHAPVETNGSIAAPDTNGRYVVYTSTQALFFSLD
TCAKILDLPSNTFHFIGGTVGGGFGGKVDTLTEPLAILAAMLTGRPVRYVFGREEEMQFGPPRGAERIYIKDGVMRDGRI
VARQIRGYFDSGAYTRLSSYAVVKCAAHLPGPYTIPNVHGDIYCVFTNRTPATAMRGFGITGMDFALECQMDKLAHLIGM
DPMEFRILNAYRDGDMKAHRREAKNTALIECVQVAAEKAKWPIREEFRRMSSRRDGGGARAAVPSTPREPAQPRSVPAQQ
RTSYDRGLPISPQPEPPPPPPPSAPSSGHGATRFSSVFGTRRR
>Mature_523_residues
MLELRKDIFADERDDNLNEVGKGTQRQDMLGHVTGTSTYFNDHKLQGMLHLRVVRSTQPHARLRRIDTSEAERSEGVRRI
IRGADVPRNLNTLLSLINFGKDDEPTLAVDKVRYRGEPIVAVVAETPRLAAEAAAKVRVDYETLPAVFDVEEALKPGAPT
VNETYPKNTFTYHERYDHQKLRFGDVERGFAQADHVLEQRYQMSPIEHAPVETNGSIAAPDTNGRYVVYTSTQALFFSLD
TCAKILDLPSNTFHFIGGTVGGGFGGKVDTLTEPLAILAAMLTGRPVRYVFGREEEMQFGPPRGAERIYIKDGVMRDGRI
VARQIRGYFDSGAYTRLSSYAVVKCAAHLPGPYTIPNVHGDIYCVFTNRTPATAMRGFGITGMDFALECQMDKLAHLIGM
DPMEFRILNAYRDGDMKAHRREAKNTALIECVQVAAEKAKWPIREEFRRMSSRRDGGGARAAVPSTPREPAQPRSVPAQQ
RTSYDRGLPISPQPEPPPPPPPSAPSSGHGATRFSSVFGTRRR

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=444, Percent_Identity=32.4324324324324, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI71773480, Length=419, Percent_Identity=30.0715990453461, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1789246, Length=481, Percent_Identity=27.027027027027, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789230, Length=448, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1786478, Length=440, Percent_Identity=25.9090909090909, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540638, Length=388, Percent_Identity=26.0309278350515, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539860, Length=466, Percent_Identity=24.4635193133047, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32566215, Length=337, Percent_Identity=23.4421364985163, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737937, Length=441, Percent_Identity=28.3446712018141, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24647199, Length=399, Percent_Identity=24.5614035087719, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647193, Length=417, Percent_Identity=25.1798561151079, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 58171; Mature: 58171

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELRKDIFADERDDNLNEVGKGTQRQDMLGHVTGTSTYFNDHKLQGMLHLRVVRSTQPH
CCCCHHHHCCCCCCCCHHHHCCCCCHHHHHHEECCCCCCCCCHHHCCEEEEEEECCCCHH
ARLRRIDTSEAERSEGVRRIIRGADVPRNLNTLLSLINFGKDDEPTLAVDKVRYRGEPIV
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHCCCCCEE
AVVAETPRLAAEAAAKVRVDYETLPAVFDVEEALKPGAPTVNETYPKNTFTYHERYDHQK
EEEECCCHHHHHHHHHEEECHHHCCHHCCHHHHHCCCCCCCCCCCCCCCEEHHHHCCCCC
LRFGDVERGFAQADHVLEQRYQMSPIEHAPVETNGSIAAPDTNGRYVVYTSTQALFFSLD
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCEEEEECCCEEEEEHH
TCAKILDLPSNTFHFIGGTVGGGFGGKVDTLTEPLAILAAMLTGRPVRYVFGREEEMQFG
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
PPRGAERIYIKDGVMRDGRIVARQIRGYFDSGAYTRLSSYAVVKCAAHLPGPYTIPNVHG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHEEEEHHHCCCCCCCCCCCC
DIYCVFTNRTPATAMRGFGITGMDFALECQMDKLAHLIGMDPMEFRILNAYRDGDMKAHR
CEEEEEECCCCHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCHHEEEEEHHCCCCHHHHH
REAKNTALIECVQVAAEKAKWPIREEFRRMSSRRDGGGARAAVPSTPREPAQPRSVPAQQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
RTSYDRGLPISPQPEPPPPPPPSAPSSGHGATRFSSVFGTRRR
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MLELRKDIFADERDDNLNEVGKGTQRQDMLGHVTGTSTYFNDHKLQGMLHLRVVRSTQPH
CCCCHHHHCCCCCCCCHHHHCCCCCHHHHHHEECCCCCCCCCHHHCCEEEEEEECCCCHH
ARLRRIDTSEAERSEGVRRIIRGADVPRNLNTLLSLINFGKDDEPTLAVDKVRYRGEPIV
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEHHHHHCCCCCEE
AVVAETPRLAAEAAAKVRVDYETLPAVFDVEEALKPGAPTVNETYPKNTFTYHERYDHQK
EEEECCCHHHHHHHHHEEECHHHCCHHCCHHHHHCCCCCCCCCCCCCCCEEHHHHCCCCC
LRFGDVERGFAQADHVLEQRYQMSPIEHAPVETNGSIAAPDTNGRYVVYTSTQALFFSLD
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCEEEEECCCEEEEEHH
TCAKILDLPSNTFHFIGGTVGGGFGGKVDTLTEPLAILAAMLTGRPVRYVFGREEEMQFG
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
PPRGAERIYIKDGVMRDGRIVARQIRGYFDSGAYTRLSSYAVVKCAAHLPGPYTIPNVHG
CCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHEEEEHHHCCCCCCCCCCCC
DIYCVFTNRTPATAMRGFGITGMDFALECQMDKLAHLIGMDPMEFRILNAYRDGDMKAHR
CEEEEEECCCCHHHHHCCCCCCCCEEEEECHHHHHHHHCCCCHHEEEEEHHCCCCHHHHH
REAKNTALIECVQVAAEKAKWPIREEFRRMSSRRDGGGARAAVPSTPREPAQPRSVPAQQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
RTSYDRGLPISPQPEPPPPPPPSAPSSGHGATRFSSVFGTRRR
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA