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The map label for this gene is fabF [H]

Identifier: 146341577

GI number: 146341577

Start: 4866747

End: 4868021

Strand: Direct

Name: fabF [H]

Synonym: BRADO4678

Alternate gene names: 146341577

Gene position: 4866747-4868021 (Clockwise)

Preceding gene: 146341576

Following gene: 146341578

Centisome position: 65.27

GC content: 66.98

Gene sequence:

>1275_bases
ATGAGTGTACGCGACAAGTTTGGACGCCCCGTCGTGGTCGTGACGGGCATGGGCATCGTCACCTCGCTGGGTGCGGGCAA
GTCCGACAATTGGACCAAGCTGGTGGCCGGCGAGTCCGGCATCCGCACCATCACGCGCTTCCCAATCGACGGGTTGAAGA
CGACGATGGCCGGCACGGTGGACTTCGTGCCAGTCGCGCCGTTCACCTCGACCGGCCTGTCCGAACGGCTCGGCCACATG
GCCGTGGAGGAAGCGATCGCGCAGGCCGGCATCGGCTCCAAGGGCGACTTCCCGGGTCCGCTGTTTCTCGCTGTCGCGCC
GGTCGAAATCGAGTGGCCGCAGCGGCTCGAGCTCGCGCATGAGGTCGGCGGCACGCACTTCACCTATGACGACCTCCTGA
AGGTCTGCGGCGGCGGCAAGTTCGTCAACTACCACCACCGCTTCCTGTTCGGCTCGGTCGCCGACTCGTTGTCGGATACA
TTCGGTACCAAGGGCTCGCCGATCTCACTGTCGACCGCCTGCGCCTCCGGCGCTACCGCGATCCAGCTCGGCGTCGAGGC
CATCCGCCGCGGCGAGACCGATGTCGCGCTGTGCGCGGCGACCGAAGGCTCGGTCAATCCGGAAGGCCTGGTGCGCTTCT
CGCTGCTGTCGGCGCTATCGACCCAGAACGATCCGCCGCAGGCCGCCTCCAAGCCGTTCTCCAAGAACCGTGACGGCTTC
GTCATGGCCGAAGGCGCCGGCGCGCTGGTGCTGGAAAGCTACGATGCGGCCGTGGCGCGTGGCGCGAAGATCCTCGGCGT
CGTCGCAGGCTGCGGCGAGCTGACCGATTCCTTCCACCGCACCCGCTCCTCGCCGGACGGCAAGCCGATCATCGGCTGCA
TCCGGAAAGCCCTGGCCGATGCCGGCATGGCGCCGGAGCAGATCGACCACATCAACGCGCATGGCACCGCCACGCCCGAG
AACGACAAGATGGAATATGTCGGCGTGTCCGCCGTGTTCGGCGAGCACACCGGCAAGATCCCGGTCTCGTCCAACAAGTC
GATGGTCGGCCACACCATCTCCGCGGCCGGCGCGGTCGAGGCGATCATCTCGCTGCTGACGCTCGAGCATCAGCTGATCC
CGCCGACCATCAACTACGACATTCCGGATCCCGCGATCCTGTTCGACGTCGTCGGCAACAAGGCCCGCGAGGCGCGCGTC
ACGGCCGTGATGTCGAACTCGTTCGGCTTCGGCGGCCAGAACGCCTCGCTGATCCTGACCCGCGAACCGGCCTGA

Upstream 100 bases:

>100_bases
GTGGTGGTCGGTGCTGGCCATTACCGCGGCGAAGGCATGGCCTTGGTCGAAGCTGTCAAGTGAACGCGGCGCGCGGCTAG
ACGACGCGACGGGGGACATC

Downstream 100 bases:

>100_bases
TCCGCCTGTCGCATCGATGAGTCTCCTGCCCCTCCGGACCAAGCTCGTCATCCGCCAGGAGGTGAAGTCGCTCGGATCCT
CCGCCGTCGGCGCACTGACG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSVRDKFGRPVVVVTGMGIVTSLGAGKSDNWTKLVAGESGIRTITRFPIDGLKTTMAGTVDFVPVAPFTSTGLSERLGHM
AVEEAIAQAGIGSKGDFPGPLFLAVAPVEIEWPQRLELAHEVGGTHFTYDDLLKVCGGGKFVNYHHRFLFGSVADSLSDT
FGTKGSPISLSTACASGATAIQLGVEAIRRGETDVALCAATEGSVNPEGLVRFSLLSALSTQNDPPQAASKPFSKNRDGF
VMAEGAGALVLESYDAAVARGAKILGVVAGCGELTDSFHRTRSSPDGKPIIGCIRKALADAGMAPEQIDHINAHGTATPE
NDKMEYVGVSAVFGEHTGKIPVSSNKSMVGHTISAAGAVEAIISLLTLEHQLIPPTINYDIPDPAILFDVVGNKAREARV
TAVMSNSFGFGGQNASLILTREPA

Sequences:

>Translated_424_residues
MSVRDKFGRPVVVVTGMGIVTSLGAGKSDNWTKLVAGESGIRTITRFPIDGLKTTMAGTVDFVPVAPFTSTGLSERLGHM
AVEEAIAQAGIGSKGDFPGPLFLAVAPVEIEWPQRLELAHEVGGTHFTYDDLLKVCGGGKFVNYHHRFLFGSVADSLSDT
FGTKGSPISLSTACASGATAIQLGVEAIRRGETDVALCAATEGSVNPEGLVRFSLLSALSTQNDPPQAASKPFSKNRDGF
VMAEGAGALVLESYDAAVARGAKILGVVAGCGELTDSFHRTRSSPDGKPIIGCIRKALADAGMAPEQIDHINAHGTATPE
NDKMEYVGVSAVFGEHTGKIPVSSNKSMVGHTISAAGAVEAIISLLTLEHQLIPPTINYDIPDPAILFDVVGNKAREARV
TAVMSNSFGFGGQNASLILTREPA
>Mature_423_residues
SVRDKFGRPVVVVTGMGIVTSLGAGKSDNWTKLVAGESGIRTITRFPIDGLKTTMAGTVDFVPVAPFTSTGLSERLGHMA
VEEAIAQAGIGSKGDFPGPLFLAVAPVEIEWPQRLELAHEVGGTHFTYDDLLKVCGGGKFVNYHHRFLFGSVADSLSDTF
GTKGSPISLSTACASGATAIQLGVEAIRRGETDVALCAATEGSVNPEGLVRFSLLSALSTQNDPPQAASKPFSKNRDGFV
MAEGAGALVLESYDAAVARGAKILGVVAGCGELTDSFHRTRSSPDGKPIIGCIRKALADAGMAPEQIDHINAHGTATPEN
DKMEYVGVSAVFGEHTGKIPVSSNKSMVGHTISAAGAVEAIISLLTLEHQLIPPTINYDIPDPAILFDVVGNKAREARVT
AVMSNSFGFGGQNASLILTREPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=434, Percent_Identity=34.5622119815668, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=40.8163265306122, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=32.1167883211679, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1787337, Length=427, Percent_Identity=37.0023419203747, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788663, Length=428, Percent_Identity=32.0093457943925, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71983541, Length=285, Percent_Identity=36.140350877193, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71983535, Length=268, Percent_Identity=37.3134328358209, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=274, Percent_Identity=29.1970802919708, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=264, Percent_Identity=27.6515151515151, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=29.0178571428571, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24644341, Length=438, Percent_Identity=34.2465753424658, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920632, Length=278, Percent_Identity=30.2158273381295, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI221330659, Length=278, Percent_Identity=30.2158273381295, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581345, Length=274, Percent_Identity=27.7372262773723, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44188; Mature: 44056

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRDKFGRPVVVVTGMGIVTSLGAGKSDNWTKLVAGESGIRTITRFPIDGLKTTMAGTV
CCCCHHHCCCEEEEECCHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCE
DFVPVAPFTSTGLSERLGHMAVEEAIAQAGIGSKGDFPGPLFLAVAPVEIEWPQRLELAH
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECEEECCCHHHHHHH
EVGGTHFTYDDLLKVCGGGKFVNYHHRFLFGSVADSLSDTFGTKGSPISLSTACASGATA
HCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCCHH
IQLGVEAIRRGETDVALCAATEGSVNPEGLVRFSLLSALSTQNDPPQAASKPFSKNRDGF
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCE
VMAEGAGALVLESYDAAVARGAKILGVVAGCGELTDSFHRTRSSPDGKPIIGCIRKALAD
EEECCCCEEEEECCHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AGMAPEQIDHINAHGTATPENDKMEYVGVSAVFGEHTGKIPVSSNKSMVGHTISAAGAVE
CCCCHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHCCHHHHHHHHH
AIISLLTLEHQLIPPTINYDIPDPAILFDVVGNKAREARVTAVMSNSFGFGGQNASLILT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEEEEE
REPA
ECCC
>Mature Secondary Structure 
SVRDKFGRPVVVVTGMGIVTSLGAGKSDNWTKLVAGESGIRTITRFPIDGLKTTMAGTV
CCCHHHCCCEEEEECCHHHHHCCCCCCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCE
DFVPVAPFTSTGLSERLGHMAVEEAIAQAGIGSKGDFPGPLFLAVAPVEIEWPQRLELAH
EEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECEEECCCHHHHHHH
EVGGTHFTYDDLLKVCGGGKFVNYHHRFLFGSVADSLSDTFGTKGSPISLSTACASGATA
HCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCCHH
IQLGVEAIRRGETDVALCAATEGSVNPEGLVRFSLLSALSTQNDPPQAASKPFSKNRDGF
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCE
VMAEGAGALVLESYDAAVARGAKILGVVAGCGELTDSFHRTRSSPDGKPIIGCIRKALAD
EEECCCCEEEEECCHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
AGMAPEQIDHINAHGTATPENDKMEYVGVSAVFGEHTGKIPVSSNKSMVGHTISAAGAVE
CCCCHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCHHCCHHHHHHHHH
AIISLLTLEHQLIPPTINYDIPDPAILFDVVGNKAREARVTAVMSNSFGFGGQNASLILT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEEEEE
REPA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]