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The map label for this gene is qor [C]

Identifier: 146341539

GI number: 146341539

Start: 4828120

End: 4829136

Strand: Direct

Name: qor [C]

Synonym: BRADO4637

Alternate gene names: 146341539

Gene position: 4828120-4829136 (Clockwise)

Preceding gene: 146341535

Following gene: 146341540

Centisome position: 64.75

GC content: 65.49

Gene sequence:

>1017_bases
ATGAAGGCCGTCGGTTACCAGCAGTCGCTGCCCATCACGGACGAGCGCGCGCTGTTCGATTTCGAGACCGCCAAACCCGA
ACCGAAAGGGCGCGATCTCCGCGTCGCGGTGAAGGCGGTCTCGGTCAATCCGGTCGACACCAAGGTGCGCAAGCGCGCCG
CCCCACCGGCCGGCGAGAGCAAGATCCTCGGCTACGACGCCGCCGGCGTGGTCGAGGCGGTCGGCCCCGAGGTGACACTG
TTCAAGGCCGGTGATGAAGTGTTCTACGCCGGCTCGATTCTGCGCCAGGGCACCAACGCCGAATTCCATCTCGTCGACGA
GCGCATCGTCGGCCACAAGCCGAAGAGCCTTTCGTTCGCCGAGGCTGCCGCTTTGCCCCTGACCTCGATCACCGCCTGGG
AATTGCTGTTCGACCGGCTCGGCGCCGTCCCCGGCAAGAGCCTCGACGACCGCACCTTGCTGATCACGGGTGCGGCCGGC
GGCGTCGGCTCGATCCTGACCCAGCTGGCGCGCCGCCTCACCGGCCTGACCGTGCTCGCGACCGCGACGCGGCCGGAATC
GCGCGACTGGTGCCTCTCGCTCGGCGCCCATGCCGTGATCGACCACGCCAAGCCGATGAAGGAGCAGATCGACGCGCTCA
AGCTGCCTCCCGTCGCGCTGATTGCAAGCCTCACTCACACCGACCAGCACTACAAGGCGATCGCCGACTTCATGACACCG
CAGGGCAAGTTCGGCCTGATCGACGATCCCGCCGAGTTCTCGCTCGCCGCCTTCAAGGGCAAGGCGATCTCGATCCATTG
GGAATCGATGTTCACGCGCTCCTCGTTCACGACGCCCGACATCATCGCCCAGCACAATCTGCTCAACGACGTCTCCGATC
TGATCGACAAGGGCGTGATCCGCACCACCCTCGGCGACAACTACGGCACCATCAATGCCAAGAACCTCAAGCGCGCGCAT
GCCCTGATCGAGAGCAACACATCTCGCGGCAAGATCGTGCTGGAGGGATGGGGCTGA

Upstream 100 bases:

>100_bases
TAGTATCCAAACGGGGACTAGTTCCCCATATTTACAGTACTTGTCGAAATGACGCCAGCAGGACAAGTAGGCCCTATGAA
AGGCCAGCCAGGAGGTTGTC

Downstream 100 bases:

>100_bases
CCTCGTAGGGGGGACAAAGGCGCAGCTCTGCTCTCTCCAAGCTCGAGATCGCAGTGGCGCCGTGCCCACCGTCTCGCCGA
CGCGCTCTCTGATCGACGGT

Product: putative oxidoreductase quinone oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVGYQQSLPITDERALFDFETAKPEPKGRDLRVAVKAVSVNPVDTKVRKRAAPPAGESKILGYDAAGVVEAVGPEVTL
FKAGDEVFYAGSILRQGTNAEFHLVDERIVGHKPKSLSFAEAAALPLTSITAWELLFDRLGAVPGKSLDDRTLLITGAAG
GVGSILTQLARRLTGLTVLATATRPESRDWCLSLGAHAVIDHAKPMKEQIDALKLPPVALIASLTHTDQHYKAIADFMTP
QGKFGLIDDPAEFSLAAFKGKAISIHWESMFTRSSFTTPDIIAQHNLLNDVSDLIDKGVIRTTLGDNYGTINAKNLKRAH
ALIESNTSRGKIVLEGWG

Sequences:

>Translated_338_residues
MKAVGYQQSLPITDERALFDFETAKPEPKGRDLRVAVKAVSVNPVDTKVRKRAAPPAGESKILGYDAAGVVEAVGPEVTL
FKAGDEVFYAGSILRQGTNAEFHLVDERIVGHKPKSLSFAEAAALPLTSITAWELLFDRLGAVPGKSLDDRTLLITGAAG
GVGSILTQLARRLTGLTVLATATRPESRDWCLSLGAHAVIDHAKPMKEQIDALKLPPVALIASLTHTDQHYKAIADFMTP
QGKFGLIDDPAEFSLAAFKGKAISIHWESMFTRSSFTTPDIIAQHNLLNDVSDLIDKGVIRTTLGDNYGTINAKNLKRAH
ALIESNTSRGKIVLEGWG
>Mature_338_residues
MKAVGYQQSLPITDERALFDFETAKPEPKGRDLRVAVKAVSVNPVDTKVRKRAAPPAGESKILGYDAAGVVEAVGPEVTL
FKAGDEVFYAGSILRQGTNAEFHLVDERIVGHKPKSLSFAEAAALPLTSITAWELLFDRLGAVPGKSLDDRTLLITGAAG
GVGSILTQLARRLTGLTVLATATRPESRDWCLSLGAHAVIDHAKPMKEQIDALKLPPVALIASLTHTDQHYKAIADFMTP
QGKFGLIDDPAEFSLAAFKGKAISIHWESMFTRSSFTTPDIIAQHNLLNDVSDLIDKGVIRTTLGDNYGTINAKNLKRAH
ALIESNTSRGKIVLEGWG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=330, Percent_Identity=28.7878787878788, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI194239674, Length=185, Percent_Identity=35.6756756756757, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI13236495, Length=185, Percent_Identity=35.6756756756757, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194239676, Length=185, Percent_Identity=35.6756756756757, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI24308257, Length=164, Percent_Identity=32.3170731707317, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI22538446, Length=189, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI22538444, Length=189, Percent_Identity=31.7460317460317, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790485, Length=322, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71987554, Length=163, Percent_Identity=34.3558282208589, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=245, Percent_Identity=30.2040816326531, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36399; Mature: 36399

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYQQSLPITDERALFDFETAKPEPKGRDLRVAVKAVSVNPVDTKVRKRAAPPAGES
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCC
KILGYDAAGVVEAVGPEVTLFKAGDEVFYAGSILRQGTNAEFHLVDERIVGHKPKSLSFA
EEEECCCCHHHHHCCCCEEEEECCCCEEEECHHHHCCCCCEEEEECHHHHCCCCCCCCHH
EAAALPLTSITAWELLFDRLGAVPGKSLDDRTLLITGAAGGVGSILTQLARRLTGLTVLA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TATRPESRDWCLSLGAHAVIDHAKPMKEQIDALKLPPVALIASLTHTDQHYKAIADFMTP
ECCCCCCCHHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCC
QGKFGLIDDPAEFSLAAFKGKAISIHWESMFTRSSFTTPDIIAQHNLLNDVSDLIDKGVI
CCCCCCCCCCHHHEEEEECCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEE
RTTLGDNYGTINAKNLKRAHALIESNTSRGKIVLEGWG
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAVGYQQSLPITDERALFDFETAKPEPKGRDLRVAVKAVSVNPVDTKVRKRAAPPAGES
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCC
KILGYDAAGVVEAVGPEVTLFKAGDEVFYAGSILRQGTNAEFHLVDERIVGHKPKSLSFA
EEEECCCCHHHHHCCCCEEEEECCCCEEEECHHHHCCCCCEEEEECHHHHCCCCCCCCHH
EAAALPLTSITAWELLFDRLGAVPGKSLDDRTLLITGAAGGVGSILTQLARRLTGLTVLA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEE
TATRPESRDWCLSLGAHAVIDHAKPMKEQIDALKLPPVALIASLTHTDQHYKAIADFMTP
ECCCCCCCHHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCC
QGKFGLIDDPAEFSLAAFKGKAISIHWESMFTRSSFTTPDIIAQHNLLNDVSDLIDKGVI
CCCCCCCCCCHHHEEEEECCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEE
RTTLGDNYGTINAKNLKRAHALIESNTSRGKIVLEGWG
EEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]