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The map label for this gene is nadA [H]

Identifier: 146341440

GI number: 146341440

Start: 4730975

End: 4731961

Strand: Reverse

Name: nadA [H]

Synonym: BRADO4531

Alternate gene names: 146341440

Gene position: 4731961-4730975 (Counterclockwise)

Preceding gene: 146341441

Following gene: 146341439

Centisome position: 63.46

GC content: 65.65

Gene sequence:

>987_bases
ATGGCCGGGACCGTTTTGGCTGCCGTCGCGCCGAAGTCGTCTGTTGCTGACCGCCTGAAGCGGGTGATCCCGCCGCCCGA
ATGGGCCGTCTACGAGGAGGATGTCGAGGCCATCCTCGCGCTCAAGCGCCGGCGCAACGCCTTGCTGCTGGCGCACAACT
ACCAGACGCCCGAGATATTCCACGGCGTCGCAGACATCGTCGGCGACAGCCTGCTGCTCGCGCGCGAGGCGACCAAGGTC
GACGCCGAGGTGATCGTGCTCGCCGGCGTGCATTTCATGGCGGAGACGGCGAAGCTGCTCAATCCCGGGAAGACGGTGCT
GATCCCGGACCTGCAGGCCGGCTGCTCGCTCGCGGACTCCATCACCGCCGATGACGTCCGGCTGATGCGCGCGCGCCATC
CCGGCGCGCCGGTGGTCGCCTATGTCAACACCTCGGTTTCGGTGAAGGCCGAGTCCGATGTCTGCTGCACCTCGGGCAAT
GCGCGCCAAATCGTGGAGTCGCTCGGCACGGATCACGTCATCATGCTTCCGGACGAGTATCTCGCCCGCAATGTCGCGGC
GCAGACCAAGGTCCGGATCACGGCGTGGAAGGGACATTGCGAGGTGCATGAGCGCTTCAGCGCCGAGGATGTCCGCACGC
TGCGCGACAATCATCCCGGGGTCACCGTGCTCGCGCATCCCGAATGTCCGCCGGAGGTGGTGGCGGAAGCGGACTTCGCC
GGCTCGACGGCGGCGATGTCCGACTATGTCGGCGCCAAGCGGCCGGCGCGGGTGGTTCTCCTGACAGAATGCTCGATGAG
CGACAATGTTGCGGTGATGTACCCCGACATCGAGTTCGTCCGGCCCTGCAATCTGTGCCCGCACATGAAGCGGATCACCT
TGAAGAACATCCGTCATGCGCTCGAGACCAACACGCATGAGGTGACGATCGATCCCGCGATGGCCGAGCGCGCGCGGCGT
TCAGTGGAAAGGATGCTGGCGCTATGA

Upstream 100 bases:

>100_bases
TCGGAACCAAGCTGCCGCTCTCGCGGTCGTGATCCCCAGCGCTTGACAAGACTTATGCTCAGGATAAGTATAAGCCATCT
TATGCTCAAGGAGAGTATAA

Downstream 100 bases:

>100_bases
GCACCGATCTCTCCAGTCTCATCGGCCGTCCCGTGATCATCGGCGGCGGCGCCGCCGGGCTGATGACGGCGCTGCAACTG
GCACCCGAGCCCGTCGTACT

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAGTVLAAVAPKSSVADRLKRVIPPPEWAVYEEDVEAILALKRRRNALLLAHNYQTPEIFHGVADIVGDSLLLAREATKV
DAEVIVLAGVHFMAETAKLLNPGKTVLIPDLQAGCSLADSITADDVRLMRARHPGAPVVAYVNTSVSVKAESDVCCTSGN
ARQIVESLGTDHVIMLPDEYLARNVAAQTKVRITAWKGHCEVHERFSAEDVRTLRDNHPGVTVLAHPECPPEVVAEADFA
GSTAAMSDYVGAKRPARVVLLTECSMSDNVAVMYPDIEFVRPCNLCPHMKRITLKNIRHALETNTHEVTIDPAMAERARR
SVERMLAL

Sequences:

>Translated_328_residues
MAGTVLAAVAPKSSVADRLKRVIPPPEWAVYEEDVEAILALKRRRNALLLAHNYQTPEIFHGVADIVGDSLLLAREATKV
DAEVIVLAGVHFMAETAKLLNPGKTVLIPDLQAGCSLADSITADDVRLMRARHPGAPVVAYVNTSVSVKAESDVCCTSGN
ARQIVESLGTDHVIMLPDEYLARNVAAQTKVRITAWKGHCEVHERFSAEDVRTLRDNHPGVTVLAHPECPPEVVAEADFA
GSTAAMSDYVGAKRPARVVLLTECSMSDNVAVMYPDIEFVRPCNLCPHMKRITLKNIRHALETNTHEVTIDPAMAERARR
SVERMLAL
>Mature_327_residues
AGTVLAAVAPKSSVADRLKRVIPPPEWAVYEEDVEAILALKRRRNALLLAHNYQTPEIFHGVADIVGDSLLLAREATKVD
AEVIVLAGVHFMAETAKLLNPGKTVLIPDLQAGCSLADSITADDVRLMRARHPGAPVVAYVNTSVSVKAESDVCCTSGNA
RQIVESLGTDHVIMLPDEYLARNVAAQTKVRITAWKGHCEVHERFSAEDVRTLRDNHPGVTVLAHPECPPEVVAEADFAG
STAAMSDYVGAKRPARVVLLTECSMSDNVAVMYPDIEFVRPCNLCPHMKRITLKNIRHALETNTHEVTIDPAMAERARRS
VERMLAL

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=318, Percent_Identity=35.2201257861635, Blast_Score=172, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 35761; Mature: 35629

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTVLAAVAPKSSVADRLKRVIPPPEWAVYEEDVEAILALKRRRNALLLAHNYQTPEIF
CCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
HGVADIVGDSLLLAREATKVDAEVIVLAGVHFMAETAKLLNPGKTVLIPDLQAGCSLADS
HHHHHHHCCCEEEEHHCCCCCCEEEEEECHHHHHHHHHHCCCCCEEEECCCHHCCCHHCC
ITADDVRLMRARHPGAPVVAYVNTSVSVKAESDVCCTSGNARQIVESLGTDHVIMLPDEY
CCHHHHHHHHHCCCCCCEEEEEECEEEEEECCCEEECCCCHHHHHHHHCCCEEEECCHHH
LARNVAAQTKVRITAWKGHCEVHERFSAEDVRTLRDNHPGVTVLAHPECPPEVVAEADFA
HHHHHHHHCEEEEEEECCCHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCC
GSTAAMSDYVGAKRPARVVLLTECSMSDNVAVMYPDIEFVRPCNLCPHMKRITLKNIRHA
CCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHH
LETNTHEVTIDPAMAERARRSVERMLAL
HHCCCCEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGTVLAAVAPKSSVADRLKRVIPPPEWAVYEEDVEAILALKRRRNALLLAHNYQTPEIF
CCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHH
HGVADIVGDSLLLAREATKVDAEVIVLAGVHFMAETAKLLNPGKTVLIPDLQAGCSLADS
HHHHHHHCCCEEEEHHCCCCCCEEEEEECHHHHHHHHHHCCCCCEEEECCCHHCCCHHCC
ITADDVRLMRARHPGAPVVAYVNTSVSVKAESDVCCTSGNARQIVESLGTDHVIMLPDEY
CCHHHHHHHHHCCCCCCEEEEEECEEEEEECCCEEECCCCHHHHHHHHCCCEEEECCHHH
LARNVAAQTKVRITAWKGHCEVHERFSAEDVRTLRDNHPGVTVLAHPECPPEVVAEADFA
HHHHHHHHCEEEEEEECCCHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCC
GSTAAMSDYVGAKRPARVVLLTECSMSDNVAVMYPDIEFVRPCNLCPHMKRITLKNIRHA
CCHHHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHH
LETNTHEVTIDPAMAERARRSVERMLAL
HHCCCCEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]