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The map label for this gene is dapA [H]

Identifier: 146341388

GI number: 146341388

Start: 4673448

End: 4674338

Strand: Reverse

Name: dapA [H]

Synonym: BRADO4475

Alternate gene names: 146341388

Gene position: 4674338-4673448 (Counterclockwise)

Preceding gene: 146341390

Following gene: 146341387

Centisome position: 62.69

GC content: 64.31

Gene sequence:

>891_bases
ATGGCAGCCAAGACGAATTTCCGAGGCTCTTTCACCGCCTTGGTGACCCCTTTCAAGAACGGATCCGTCGATGAGGCGGC
GTTCCGCAGCCTGGTGAACTGGCAGATCGATGAGGGGACCAACGGCCTCGTGCCAGTCGGCACGACCGGCGAGAGTCCGA
CCTTGAGCCATGACGAGCACAAGCAGGTGGTCGAGTGGTGCATCGCCGAGGCCAAGGGCAGGGTGCCCGTGGTCGCCGGT
GCCGGCTCAAATTCGACCAAGGAGGCCGTCGAGCTCGCCCAACATGCCGAGAAGGCCGGCGCCGATGCCGTGCTGGTCGT
CACGCCGTACTACAACAAGCCGACGCAGGAAGGCCTGTATCAGCACTTCAAGGCGATCAACGACGCGATCGGCATTCCGA
TCATCATCTACAACATCCCGCCGCGCTCGGTGATCGACATGTCCGTCGACACCATGAAGCGGCTGTACGACCTGAAGAAC
ATCGCCGGCGTGAAGGACGCCACCGCCAGCATGGTGCGGGTGTCGCAGCAGCGCGCGGCGCTCGGCGCGGAGTTCAACCA
GCTCTCCGGAGAGGACGCCACCATCATCGGCTACATGGCCCATGGCGGCCATGGCTGCATCTCGGTGACGTCGAACGTGG
CGCCGCGGCTGTGCGCGGAGTTCCACGCTGCCTGGCAGAAGGGCGATGTCGCCACGGCGCTGAAGATCCACGACAAGCTG
ATGCCGCTGCACACCAATTTGTTCATCGAGTCGAACCCGGCGCCGGTGAAATACGCGCTGTCGCTGCTCGGCAAGATCGA
CGAGAAGCTGCGGCTGCCGATGGTGCCGGTGTCCGAGCCGACCCGTGTGGCGGTGCGCCAGGCCATGGTGCATGCCGGGC
TGATCAACTGA

Upstream 100 bases:

>100_bases
TGAGAAGGCAGCCGACGTCAGGGCAGGCCTTCCGCCAGATGTCCAGACCCGGTATGAAGTGCGCTTCGCTCTGGGGCAAC
GCGCGTTGGGAGGGAGTTTC

Downstream 100 bases:

>100_bases
GCTGAGCCGTTTCTTGCACGTCTGATGGGGAGACAGACATGTTGAAGGAATTCCGAGAATTCGCGATGAAGGGCAATGTC
GTCGACCTCGCGGTCGGCGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAAKTNFRGSFTALVTPFKNGSVDEAAFRSLVNWQIDEGTNGLVPVGTTGESPTLSHDEHKQVVEWCIAEAKGRVPVVAG
AGSNSTKEAVELAQHAEKAGADAVLVVTPYYNKPTQEGLYQHFKAINDAIGIPIIIYNIPPRSVIDMSVDTMKRLYDLKN
IAGVKDATASMVRVSQQRAALGAEFNQLSGEDATIIGYMAHGGHGCISVTSNVAPRLCAEFHAAWQKGDVATALKIHDKL
MPLHTNLFIESNPAPVKYALSLLGKIDEKLRLPMVPVSEPTRVAVRQAMVHAGLIN

Sequences:

>Translated_296_residues
MAAKTNFRGSFTALVTPFKNGSVDEAAFRSLVNWQIDEGTNGLVPVGTTGESPTLSHDEHKQVVEWCIAEAKGRVPVVAG
AGSNSTKEAVELAQHAEKAGADAVLVVTPYYNKPTQEGLYQHFKAINDAIGIPIIIYNIPPRSVIDMSVDTMKRLYDLKN
IAGVKDATASMVRVSQQRAALGAEFNQLSGEDATIIGYMAHGGHGCISVTSNVAPRLCAEFHAAWQKGDVATALKIHDKL
MPLHTNLFIESNPAPVKYALSLLGKIDEKLRLPMVPVSEPTRVAVRQAMVHAGLIN
>Mature_295_residues
AAKTNFRGSFTALVTPFKNGSVDEAAFRSLVNWQIDEGTNGLVPVGTTGESPTLSHDEHKQVVEWCIAEAKGRVPVVAGA
GSNSTKEAVELAQHAEKAGADAVLVVTPYYNKPTQEGLYQHFKAINDAIGIPIIIYNIPPRSVIDMSVDTMKRLYDLKNI
AGVKDATASMVRVSQQRAALGAEFNQLSGEDATIIGYMAHGGHGCISVTSNVAPRLCAEFHAAWQKGDVATALKIHDKLM
PLHTNLFIESNPAPVKYALSLLGKIDEKLRLPMVPVSEPTRVAVRQAMVHAGLIN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=297, Percent_Identity=24.5791245791246, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=47.0790378006873, Blast_Score=274, Evalue=4e-75,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=30.4054054054054, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=30.9859154929577, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789620, Length=235, Percent_Identity=33.6170212765957, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31834; Mature: 31703

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKTNFRGSFTALVTPFKNGSVDEAAFRSLVNWQIDEGTNGLVPVGTTGESPTLSHDEH
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCEEECCCCCCEEEECCCCCCCCCCCHHH
KQVVEWCIAEAKGRVPVVAGAGSNSTKEAVELAQHAEKAGADAVLVVTPYYNKPTQEGLY
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
QHFKAINDAIGIPIIIYNIPPRSVIDMSVDTMKRLYDLKNIAGVKDATASMVRVSQQRAA
HHHHHHHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGAEFNQLSGEDATIIGYMAHGGHGCISVTSNVAPRLCAEFHAAWQKGDVATALKIHDKL
HCCHHHHCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MPLHTNLFIESNPAPVKYALSLLGKIDEKLRLPMVPVSEPTRVAVRQAMVHAGLIN
CCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAKTNFRGSFTALVTPFKNGSVDEAAFRSLVNWQIDEGTNGLVPVGTTGESPTLSHDEH
CCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCEEECCCCCCEEEECCCCCCCCCCCHHH
KQVVEWCIAEAKGRVPVVAGAGSNSTKEAVELAQHAEKAGADAVLVVTPYYNKPTQEGLY
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
QHFKAINDAIGIPIIIYNIPPRSVIDMSVDTMKRLYDLKNIAGVKDATASMVRVSQQRAA
HHHHHHHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LGAEFNQLSGEDATIIGYMAHGGHGCISVTSNVAPRLCAEFHAAWQKGDVATALKIHDKL
HCCHHHHCCCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MPLHTNLFIESNPAPVKYALSLLGKIDEKLRLPMVPVSEPTRVAVRQAMVHAGLIN
CCEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]