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The map label for this gene is aceA [C]

Identifier: 146340697

GI number: 146340697

Start: 3911810

End: 3913447

Strand: Direct

Name: aceA [C]

Synonym: BRADO3748

Alternate gene names: 146340697

Gene position: 3911810-3913447 (Clockwise)

Preceding gene: 146340695

Following gene: 146340700

Centisome position: 52.46

GC content: 64.65

Gene sequence:

>1638_bases
ATGAACTTCCAACCGCGTGGACTGAACGACCAGGCTCTCCAAGGCTCCTCGTCCTACCAGGCCGAGGTCGAGGCGGCGCG
TGCGCTGCTCGAGACCAACCCGACCTGGAACGGCGTCACCGCCGAGGCCGTGGCGCGCATGCGCCTGCAGAACCGCTTCA
AGACCGGTCTCGACGTGGCCCGCTACACCGCGGCCGTGATGCGCGCCGACATGGCCGCCTACGATGAGGACAGCACCAAG
TACACGCAGTCGCTCGGCTGCTGGCACGGCTTCATCGCGCAGCAGAAGCTGATCTCGATCAAGAAGCATTTTGGCCGCAC
CGACCGCCGCTACCTCTATCTCTCCGGCTGGATGATCGCGGCGCTGCGCTCCGAGTTCGGCCCGCTGCCGGACCAGTCGA
TGCACGAGAAGACCTCGGTGCCCGCGCTGATCGAGGAGCTCTATACCTTCCTGCGCCAGGCCGACTCGCGCGAGCTCAAC
GATCTGTTCCGCACGCTCGACGCCGCCCGCAAGGCCGGCGACAAGGCGAAGGAGACCGAGATCATCGCCAAGATCGACGG
CTTCCAGACCCACGTCGTCCCGGTCATCGCCGACATCGACGCCGGCTTCGGCAATGCGGAAGCGACCTATCTGCTCGCCA
AGAAGATGATCGAGGCGGGCGCCTGCGCGCTGCAGATCGAGAACCAGGTCTCGGACGAGAAGCAGTGCGGCCATCAGGAC
GGCAAGGTCACCGTGCCGCATGACGTCTTCCTGGCCAAGATCCGCGCCTGCCGCCACGCCTTCCTGGAGCTTGGCGTCGA
GGACGGCATCATCGTCACCCGCACCGACTCGCTCGGCGCTGGTCTCACGCAGCAGATCGCCTATTCGAGCCAGCCGGGCG
ATCTCGGCGACCAGTACAACAGCTTCCTCGACTGCGAGGAAGTGACGCCGGAGACCGCGCGCAGCGGCGACGTCATCATC
AACCAGAATGGCAAGATGGTCAGGCCGAAGCGGCTGCCCTCGAACCTCTATCAGTTCCGTCCCGGCACCGGTGAGGACCG
TTGCGTGCTCGACTGCATCACCTCGCTGCAGAACGGCGCCGACCTCTTGTGGATCGAGACCGAGAAGCCGCATATCGAGC
AGATCGCCAAGATGGTCGACCGCATCCGCAAGGTCATCCCGAACGCCAAGCTCGCCTACAACAACTCGCCGTCGTTCAAC
TGGACCCTCAACTTCCGTTGGCAGGTCTACGACGCGATGAAGGAGGCGGGTCAGGACGTCAGCAAGTACAACCGCGCCGA
GCTGATGAAGGCGGAGTATGACGACACCCCGCTGGCGAAGGAAGCCGACGAGCGCATCCGCACCTTCCAGGCGGATTCAG
CCAAGCGCGCCGGCATCTTCCACCACCTGATCACTCTGCCGACCTACCACACGGCCGCGCTCTCGACCGACAACCTCGCC
CGCGAGTATTTCGGCGAGCAGGGCATGCTGGGCTACGTCAAGAACGTCCAGCGCGCCGAAATCCGCCAGGGCATCGCCTG
CGTCAAGCACCAGAACATGGCCGGCTCCGATATCGGCGACGACCACAAGGAATACTTCGCCGGCGAGAAGGCCCTGAAGG
CCGGCGGCGCGCACAACACGATGAATCAGTTCGGCTGA

Upstream 100 bases:

>100_bases
TATCTGTAAAGTGTGACAAGTTTTCCGCGCAATGGCTAGTCCGCTGTCGCAACGTGCTTAAAACAGGTCCCAGGTTGTCG
TTAACCAAGGGATCACGGAC

Downstream 100 bases:

>100_bases
TCTCCGCCGGGTGAAGCGCTGAACTGATGAGACCCGTCTGGGGCGGCAACGCTCCAGGCGGGTTTTGCTTTGGCGCGGAC
GATCCAAGGCGCAGCTCGGT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNFQPRGLNDQALQGSSSYQAEVEAARALLETNPTWNGVTAEAVARMRLQNRFKTGLDVARYTAAVMRADMAAYDEDSTK
YTQSLGCWHGFIAQQKLISIKKHFGRTDRRYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADSRELN
DLFRTLDAARKAGDKAKETEIIAKIDGFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHDVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAYSSQPGDLGDQYNSFLDCEEVTPETARSGDVII
NQNGKMVRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGADLLWIETEKPHIEQIAKMVDRIRKVIPNAKLAYNNSPSFN
WTLNFRWQVYDAMKEAGQDVSKYNRAELMKAEYDDTPLAKEADERIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
REYFGEQGMLGYVKNVQRAEIRQGIACVKHQNMAGSDIGDDHKEYFAGEKALKAGGAHNTMNQFG

Sequences:

>Translated_545_residues
MNFQPRGLNDQALQGSSSYQAEVEAARALLETNPTWNGVTAEAVARMRLQNRFKTGLDVARYTAAVMRADMAAYDEDSTK
YTQSLGCWHGFIAQQKLISIKKHFGRTDRRYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADSRELN
DLFRTLDAARKAGDKAKETEIIAKIDGFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHDVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAYSSQPGDLGDQYNSFLDCEEVTPETARSGDVII
NQNGKMVRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGADLLWIETEKPHIEQIAKMVDRIRKVIPNAKLAYNNSPSFN
WTLNFRWQVYDAMKEAGQDVSKYNRAELMKAEYDDTPLAKEADERIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
REYFGEQGMLGYVKNVQRAEIRQGIACVKHQNMAGSDIGDDHKEYFAGEKALKAGGAHNTMNQFG
>Mature_545_residues
MNFQPRGLNDQALQGSSSYQAEVEAARALLETNPTWNGVTAEAVARMRLQNRFKTGLDVARYTAAVMRADMAAYDEDSTK
YTQSLGCWHGFIAQQKLISIKKHFGRTDRRYLYLSGWMIAALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADSRELN
DLFRTLDAARKAGDKAKETEIIAKIDGFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
GKVTVPHDVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAYSSQPGDLGDQYNSFLDCEEVTPETARSGDVII
NQNGKMVRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGADLLWIETEKPHIEQIAKMVDRIRKVIPNAKLAYNNSPSFN
WTLNFRWQVYDAMKEAGQDVSKYNRAELMKAEYDDTPLAKEADERIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
REYFGEQGMLGYVKNVQRAEIRQGIACVKHQNMAGSDIGDDHKEYFAGEKALKAGGAHNTMNQFG

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=497, Percent_Identity=27.7665995975855, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17561814, Length=419, Percent_Identity=27.4463007159904, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982926, Length=419, Percent_Identity=27.4463007159904, Blast_Score=128, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320908, Length=198, Percent_Identity=32.3232323232323, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325263, Length=184, Percent_Identity=27.7173913043478, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 60851; Mature: 60851

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQPRGLNDQALQGSSSYQAEVEAARALLETNPTWNGVTAEAVARMRLQNRFKTGLDVA
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RYTAAVMRADMAAYDEDSTKYTQSLGCWHGFIAQQKLISIKKHFGRTDRRYLYLSGWMIA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHH
ALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADSRELNDLFRTLDAARKAGDKAKETE
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
IIAKIDGFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
HHHEECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCC
GKVTVPHDVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAYSSQPGDLGDQYN
CCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHH
SFLDCEEVTPETARSGDVIINQNGKMVRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGA
HCCCHHHCCCCCCCCCCEEECCCCCEECCHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCC
DLLWIETEKPHIEQIAKMVDRIRKVIPNAKLAYNNSPSFNWTLNFRWQVYDAMKEAGQDV
CEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEHHHHHHHHHHHHH
SKYNRAELMKAEYDDTPLAKEADERIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHH
REYFGEQGMLGYVKNVQRAEIRQGIACVKHQNMAGSDIGDDHKEYFAGEKALKAGGAHNT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCH
MNQFG
HHHCC
>Mature Secondary Structure
MNFQPRGLNDQALQGSSSYQAEVEAARALLETNPTWNGVTAEAVARMRLQNRFKTGLDVA
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RYTAAVMRADMAAYDEDSTKYTQSLGCWHGFIAQQKLISIKKHFGRTDRRYLYLSGWMIA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHH
ALRSEFGPLPDQSMHEKTSVPALIEELYTFLRQADSRELNDLFRTLDAARKAGDKAKETE
HHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHH
IIAKIDGFQTHVVPVIADIDAGFGNAEATYLLAKKMIEAGACALQIENQVSDEKQCGHQD
HHHEECCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEECHHCCHHHHCCCCC
GKVTVPHDVFLAKIRACRHAFLELGVEDGIIVTRTDSLGAGLTQQIAYSSQPGDLGDQYN
CCEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCHHHHH
SFLDCEEVTPETARSGDVIINQNGKMVRPKRLPSNLYQFRPGTGEDRCVLDCITSLQNGA
HCCCHHHCCCCCCCCCCEEECCCCCEECCHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCC
DLLWIETEKPHIEQIAKMVDRIRKVIPNAKLAYNNSPSFNWTLNFRWQVYDAMKEAGQDV
CEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEEEEHHHHHHHHHHHHH
SKYNRAELMKAEYDDTPLAKEADERIRTFQADSAKRAGIFHHLITLPTYHTAALSTDNLA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHH
REYFGEQGMLGYVKNVQRAEIRQGIACVKHQNMAGSDIGDDHKEYFAGEKALKAGGAHNT
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCHHHHHCCCCCCH
MNQFG
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]